Details for: LAMP5

Gene ID: 24141

Symbol: LAMP5

Ensembl ID: ENSG00000125869

Description: lysosomal associated membrane protein family member 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 3.15
    Marker Score: 2,149
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.91
    Marker Score: 3,512
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.5
    Marker Score: 792
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.41
    Marker Score: 2,270
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.05
    Marker Score: 20,728
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.47
    Marker Score: 22,033
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,682
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.13
    Marker Score: 1,060
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.04
    Marker Score: 1,107
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,043
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.95
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,737
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,284
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.84
    Marker Score: 614
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.82
    Marker Score: 590
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.79
    Marker Score: 3,284
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.61
    Marker Score: 157
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.58
    Marker Score: 363
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.52
    Marker Score: 329
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.47
    Marker Score: 562
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.46
    Marker Score: 448
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.46
    Marker Score: 632
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.45
    Marker Score: 547
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.44
    Marker Score: 153
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.43
    Marker Score: 660
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.43
    Marker Score: 112
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.41
    Marker Score: 714
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.41
    Marker Score: 1,165
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.41
    Marker Score: 217
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.4
    Marker Score: 147
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.4
    Marker Score: 496
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.4
    Marker Score: 1,858
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.39
    Marker Score: 1,600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.38
    Marker Score: 250
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.35
    Marker Score: 428
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.34
    Marker Score: 363
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.33
    Marker Score: 190
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.33
    Marker Score: 316
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.33
    Marker Score: 190
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.33
    Marker Score: 175
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.31
    Marker Score: 153
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.31
    Marker Score: 635
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.28
    Marker Score: 129
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.28
    Marker Score: 526
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.27
    Marker Score: 557
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.27
    Marker Score: 300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.26
    Marker Score: 70
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.26
    Marker Score: 176
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.26
    Marker Score: 129
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.26
    Marker Score: 1,689
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.25
    Marker Score: 171
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.25
    Marker Score: 156
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.24
    Marker Score: 302
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.24
    Marker Score: 82
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.23
    Marker Score: 312
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.23
    Marker Score: 56
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.22
    Marker Score: 106
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.22
    Marker Score: 456
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 66
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.22
    Marker Score: 86
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.22
    Marker Score: 454
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.21
    Marker Score: 92
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.21
    Marker Score: 348
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.21
    Marker Score: 537
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2
    Marker Score: 3,205
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.2
    Marker Score: 83
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.2
    Marker Score: 176
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.2
    Marker Score: 120
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2
    Marker Score: 755
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.19
    Marker Score: 188
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.19
    Marker Score: 67
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.19
    Marker Score: 342
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.18
    Marker Score: 102
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.18
    Marker Score: 176
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.17
    Marker Score: 456
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.17
    Marker Score: 57
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.16
    Marker Score: 86
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.16
    Marker Score: 404
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.16
    Marker Score: 44
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.16
    Marker Score: 165
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.16
    Marker Score: 65
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.15
    Marker Score: 169
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.15
    Marker Score: 432
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.15
    Marker Score: 90
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.15
    Marker Score: 78
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 46
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.14
    Marker Score: 143
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.14
    Marker Score: 152
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.14
    Marker Score: 31

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LAMP5 is a type II transmembrane protein that is characterized by its ability to associate with lysosomes and other membrane-bound organelles. It possesses a distinctive structure, consisting of a short cytoplasmic tail, a transmembrane domain, and a large extracellular loop. This protein is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. LAMP5 has been shown to interact with various proteins, including those involved in membrane trafficking, signaling, and cellular differentiation. **Pathways and Functions:** LAMP5 plays a critical role in regulating membrane trafficking and cellular differentiation through its interactions with various signaling pathways. Some of the key pathways and functions associated with LAMP5 include: 1. **Endosomal sorting and trafficking**: LAMP5 is involved in the sorting and trafficking of proteins and lipids within the endosomal system, including lysosomes, early endosomes, and recycling endosomes. 2. **Cellular differentiation**: LAMP5 is essential for the development and maintenance of various cell types, including immune cells, neurons, and epithelial cells. It regulates the expression of specific genes and proteins involved in cellular differentiation. 3. **Signaling and membrane trafficking**: LAMP5 interacts with signaling molecules, such as receptor tyrosine kinases and G-protein coupled receptors, to regulate membrane trafficking and cellular signaling. 4. **Autophagy and lysosomal function**: LAMP5 is involved in regulating autophagy and lysosomal function, which are critical processes for maintaining cellular homeostasis and removing damaged organelles. **Clinical Significance:** Dysregulation of LAMP5 has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: Mutations in the LAMP5 gene have been associated with immunodeficiency disorders, such as X-linked agammaglobulinemia. 2. **Neurological disorders**: LAMP5 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. 3. **Cancer**: LAMP5 is involved in regulating cell growth, differentiation, and survival, making it a potential target for cancer therapy. 4. **Infectious diseases**: LAMP5 has been shown to play a role in the regulation of immune responses to infections, suggesting its potential as a therapeutic target for infectious diseases. In conclusion, LAMP5 is a critical component of membrane trafficking and cellular differentiation, with implications for various diseases. Further research is needed to fully elucidate the mechanisms by which LAMP5 regulates cellular processes and to explore its potential as a therapeutic target.

Genular Protein ID: 3274749578

Symbol: LAMP5_HUMAN

Name: Lysosome-associated membrane glycoprotein 5

UniProtKB Accession Codes:

Q9UJQ1 B4DHZ7 B7Z9Z9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21642595

Title: BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid dendritic cells.

PubMed ID: 21642595

DOI: 10.1182/blood-2010-11-319699

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 280
  • Mass: 31472
  • Checksum: 7D811D7C04EE70B8
  • Sequence:
    • MDLQGRGVPS IDRLRVLLML FHTMAQIMAE QEVENLSGLS TNPEKDIFVV RENGTTCLMA 
EFAAKFIVPY DVWASNYVDL ITEQADIALT RGAEVKGRCG HSQSELQVFW VDRAYALKML 
FVKESHNMSK GPEATWRLSK VQFVYDSSEK THFKDAVSAG KHTANSHHLS ALVTPAGKSY 
ECQAQQTISL ASSDPQKTVT MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI 
LGLILGLVIM VTLAIYHVHH KMTANQVQIP RDRSQYKHMG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.