Details for: NAA80

Gene ID: 24142

Symbol: NAA80

Ensembl ID: ENSG00000243477

Description: N-alpha-acetyltransferase 80, NatH catalytic subunit

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.09
    Marker Score: 2,998
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.42
    Marker Score: 2,700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.1
    Marker Score: 346
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.09
    Marker Score: 350
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16,385
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.02
    Marker Score: 2,071
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,790
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,014
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.99
    Marker Score: 314
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,251
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,727
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.88
    Marker Score: 677
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.88
    Marker Score: 282
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,288
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.79
    Marker Score: 538
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,256
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.75
    Marker Score: 1,308
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.75
    Marker Score: 1,762
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.72
    Marker Score: 433
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 645
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.69
    Marker Score: 530
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2,813
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.67
    Marker Score: 268
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.65
    Marker Score: 312
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.57
    Marker Score: 415
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.51
    Marker Score: 3,289
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.48
    Marker Score: 253
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.46
    Marker Score: 242
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 121
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.46
    Marker Score: 301
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.45
    Marker Score: 287
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.43
    Marker Score: 127
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.42
    Marker Score: 187
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.42
    Marker Score: 109
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.4
    Marker Score: 139
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.39
    Marker Score: 351
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.38
    Marker Score: 211
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.37
    Marker Score: 2,253
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.37
    Marker Score: 2,476
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.37
    Marker Score: 223
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.37
    Marker Score: 527
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.36
    Marker Score: 203
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.36
    Marker Score: 179
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.34
    Marker Score: 107
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.34
    Marker Score: 125
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.33
    Marker Score: 268
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.32
    Marker Score: 427
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.32
    Marker Score: 399
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.31
    Marker Score: 1,346
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.31
    Marker Score: 305
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.31
    Marker Score: 1,136
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.3
    Marker Score: 115
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.29
    Marker Score: 317
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.29
    Marker Score: 241
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.29
    Marker Score: 144
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.29
    Marker Score: 58
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.29
    Marker Score: 281
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.28
    Marker Score: 3,307
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.28
    Marker Score: 1,199
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.28
    Marker Score: 543
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.27
    Marker Score: 118
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.27
    Marker Score: 58
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.26
    Marker Score: 198
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.26
    Marker Score: 148
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.26
    Marker Score: 150
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.25
    Marker Score: 13,446
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.25
    Marker Score: 185
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.25
    Marker Score: 122
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.25
    Marker Score: 100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.25
    Marker Score: 155
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.25
    Marker Score: 61
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.25
    Marker Score: 61
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.25
    Marker Score: 54
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 102
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.24
    Marker Score: 84
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.24
    Marker Score: 214
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.24
    Marker Score: 244
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.24
    Marker Score: 371
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.24
    Marker Score: 226
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.24
    Marker Score: 61
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.24
    Marker Score: 483
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.24
    Marker Score: 265
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.24
    Marker Score: 151
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.24
    Marker Score: 200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.24
    Marker Score: 68
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.24
    Marker Score: 107
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.24
    Marker Score: 87
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.23
    Marker Score: 227
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.23
    Marker Score: 98
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.23
    Marker Score: 219
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.23
    Marker Score: 53
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.23
    Marker Score: 234

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Acetyltransferase Activity:** NAA80 is a type II acetyltransferase, which means it requires a co-factor, likely N-acetyl-CoA, to catalyze the transfer of an acetyl group to the target protein. 2. **Target Protein Specificity:** NAA80 is known to target specific lysine residues on proteins, such as actin, tubulin, and histones, which are involved in various cellular processes. 3. **Cellular Expression:** NAA80 is expressed in a wide range of cell types, including immune cells, endothelial cells, and neurons, highlighting its importance in maintaining cellular homeostasis. 4. **Pathway Involvement:** NAA80 is involved in multiple signaling pathways, including actin polymerization and depolymerization, cytoskeleton dynamics, and regulation of protein activity. **Pathways and Functions:** 1. **Actin Polymerization and Depolymerization:** NAA80 regulates the acetylation of actin, which is essential for maintaining the dynamic balance between actin polymerization and depolymerization. This process is critical for cell motility, signaling, and structural integrity. 2. **Cytoskeleton Dynamics:** NAA80's role in regulating actin dynamics has implications for cytoskeleton organization and function, which are essential for cell shape, movement, and division. 3. **Protein Activity Regulation:** NAA80's ability to acetylate and regulate the activity of target proteins has significant implications for cellular signaling and homeostasis. 4. **Regulation of Gene Expression:** NAA80 has been implicated in the regulation of gene expression, particularly in the context of histone acetylation and chromatin remodeling. **Clinical Significance:** 1. **Disease Association:** Alterations in NAA80 expression or activity have been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. 2. **Immunological Implications:** NAA80's role in regulating immune cell function and activity has significant implications for understanding immune-related disorders and developing novel therapeutic strategies. 3. **Therapeutic Targeting:** NAA80's involvement in various signaling pathways and disease processes makes it a potential target for the development of novel therapeutic agents. 4. **Basic Research Implications:** Further studies on NAA80's functions and mechanisms of action will provide valuable insights into the regulation of protein acetylation and actin dynamics, with implications for our understanding of cellular homeostasis and disease biology. In conclusion, NAA80 is a critical gene that plays a pivotal role in regulating protein acetylation and actin dynamics. Its involvement in various signaling pathways and disease processes highlights its importance in maintaining cellular homeostasis. Further research on NAA80's functions and mechanisms of action will be essential for understanding its role in disease biology and developing novel therapeutic strategies.

Genular Protein ID: 2124024032

Symbol: NAA80_HUMAN

Name: N-alpha-acetyltransferase 80

UniProtKB Accession Codes:

Q93015 Q93014

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 13 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 Rhea 6 SABIO-RK 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10644992

Title: The putative tumour suppressor Fus-2 is an N-acetyltransferase.

PubMed ID: 10644992

DOI: 10.1038/sj.onc.1203234

PubMed ID: 11085536

Title: The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes.

PubMed ID: 11085536

PubMed ID: 30028079

Title: NAT6 acetylates the N-terminus of different forms of actin.

PubMed ID: 30028079

DOI: 10.1111/febs.14605

PubMed ID: 29581253

Title: NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility.

PubMed ID: 29581253

DOI: 10.1073/pnas.1718336115

PubMed ID: 29581307

Title: Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80.

PubMed ID: 29581307

DOI: 10.1073/pnas.1719251115

Sequence Information:

  • Length: 286
  • Mass: 31445
  • Checksum: A755E2E3367625DB
  • Sequence:
    • MELILSTSPA ELTLDPACQP KLPLDSTCQP EMTFNPGPTE LTLDPEHQPE ETPAPSLAEL 
TLEPVHRRPE LLDACADLIN DQWPRSRTSR LHSLGQSSDA FPLCLMLLSP HPTLEAAPVV 
VGHARLSRVL NQPQSLLVET VVVARALRGR GFGRRLMEGL EVFARARGFR KLHLTTHDQV 
HFYTHLGYQL GEPVQGLVFT SRRLPATLLN AFPTAPSPRP PRKAPNLTAQ AAPRGPKGPP 
LPPPPPLPEC LTISPPVPSG PPSKSLLETQ YQNVRGRPIF WMEKDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.