Details for: TFIP11

Gene ID: 24144

Symbol: TFIP11

Ensembl ID: ENSG00000100109

Description: tuftelin interacting protein 11

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.03
    Marker Score: 3,550
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,666
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.2
    Marker Score: 345
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,739
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,963
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,399
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.92
    Marker Score: 1,316
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,711
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.87
    Marker Score: 1,095
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,247
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,917
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 304
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.78
    Marker Score: 1,636
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.73
    Marker Score: 11,395
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 553
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.7
    Marker Score: 478
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,933
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 605
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.57
    Marker Score: 416
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.57
    Marker Score: 758
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.55
    Marker Score: 375
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.55
    Marker Score: 6,377
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.54
    Marker Score: 405
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.54
    Marker Score: 2,118
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 354
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.53
    Marker Score: 896
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.53
    Marker Score: 1,117
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.53
    Marker Score: 525
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.52
    Marker Score: 719
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.52
    Marker Score: 731
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.5
    Marker Score: 152
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5
    Marker Score: 1,484
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.49
    Marker Score: 329
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.49
    Marker Score: 1,334
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.48
    Marker Score: 747
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.48
    Marker Score: 1,658
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.48
    Marker Score: 152
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.48
    Marker Score: 504
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.48
    Marker Score: 513
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.48
    Marker Score: 194
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.48
    Marker Score: 437
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.48
    Marker Score: 324
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.47
    Marker Score: 477
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.47
    Marker Score: 165
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.47
    Marker Score: 1,151
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.47
    Marker Score: 914
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.46
    Marker Score: 4,792
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.46
    Marker Score: 244
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.46
    Marker Score: 1,278
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.45
    Marker Score: 284
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.45
    Marker Score: 3,879
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.45
    Marker Score: 188
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.45
    Marker Score: 6,042
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 119
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.45
    Marker Score: 111
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.45
    Marker Score: 282
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.45
    Marker Score: 658
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.44
    Marker Score: 446
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.44
    Marker Score: 394
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.44
    Marker Score: 1,384
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.44
    Marker Score: 298
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.44
    Marker Score: 138
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.43
    Marker Score: 470
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.43
    Marker Score: 458
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.43
    Marker Score: 207
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.43
    Marker Score: 284
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.43
    Marker Score: 235
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.42
    Marker Score: 92
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.42
    Marker Score: 3,123
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.42
    Marker Score: 363
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.42
    Marker Score: 206
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.42
    Marker Score: 204
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.42
    Marker Score: 1,539
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.42
    Marker Score: 174
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.42
    Marker Score: 340
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.41
    Marker Score: 534
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 399
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.41
    Marker Score: 4,084
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.41
    Marker Score: 241
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.41
    Marker Score: 3,579
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.41
    Marker Score: 101
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.41
    Marker Score: 322
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.41
    Marker Score: 98
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.41
    Marker Score: 100
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.41
    Marker Score: 89
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.4
    Marker Score: 192
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.4
    Marker Score: 107
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.4
    Marker Score: 183
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.4
    Marker Score: 162
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.4
    Marker Score: 100
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.4
    Marker Score: 294
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.4
    Marker Score: 105

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TFP11 is a relatively small protein, with a molecular weight of approximately 20-25 kDa. Its primary function is to interact with tuftelin, a protein involved in biomineralization, and regulate its activity. TFP11 also exhibits anti-catabolic properties, inhibiting the activity of DNA ligase and preventing non-homologous end joining at telomeres. Additionally, TFP11 is involved in RNA processing, particularly in the regulation of spliceosomal complex assembly and disassembly. Its presence in specific cell types, such as germ cells and intestinal epithelial cells, suggests a tissue-specific role for TFP11. **Pathways and Functions** TFP11 is involved in several cellular pathways, including: 1. **Biomineralization**: TFP11 interacts with tuftelin, a protein involved in biomineralization, and regulates its activity. This interaction is crucial for the formation of mineralized structures in various tissues. 2. **RNA Processing**: TFP11 is involved in the regulation of spliceosomal complex assembly and disassembly, which is essential for RNA processing and the production of mature mRNA. 3. **DNA Repair**: TFP11 inhibits the activity of DNA ligase, a protein involved in DNA repair, and prevents non-homologous end joining at telomeres, which can lead to telomere shortening and genomic instability. 4. **Cell Signaling**: TFP11 may also be involved in cell signaling pathways, particularly those regulating cellular growth and differentiation. **Clinical Significance** The dysregulation of TFP11 has been implicated in various diseases, including: 1. **Cancer**: Alterations in TFP11 expression have been observed in certain types of cancer, such as colon cancer, and may contribute to tumorigenesis. 2. **Neurodegenerative Diseases**: TFP11 has been implicated in neurodegenerative diseases, such as Alzheimer's disease, where its dysregulation may contribute to disease progression. 3. **Telomere Disorders**: The inhibition of non-homologous end joining at telomeres by TFP11 may contribute to telomere shortening and genomic instability, which can lead to age-related diseases. In conclusion, TFP11 is a multifunctional protein that plays a critical role in various cellular processes, including biomineralization, RNA processing, and DNA repair. Its dysregulation has been implicated in various diseases, highlighting the importance of TFP11 in maintaining tissue homeostasis and regulating cellular processes. Further research is needed to fully understand the role of TFP11 in human health and disease.

Genular Protein ID: 367368171

Symbol: TFP11_HUMAN

Name: Tuftelin-interacting protein 11

UniProtKB Accession Codes:

Q9UBB9 O95908 Q20WL0 Q5H8V8 Q9UGV7 Q9Y2Q8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 19 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 8 SAM 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 12529303

Title: Reevaluating human gene annotation: a second-generation analysis of chromosome 22.

PubMed ID: 12529303

DOI: 10.1101/gr.695703

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19103666

Title: Isolation and characterization of post-splicing lariat-intron complexes.

PubMed ID: 19103666

DOI: 10.1093/nar/gkn1002

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24304693

Title: Identification of a novel component C2ORF3 in the lariat-intron complex: lack of C2ORF3 interferes with pre-mRNA splicing via intron turnover pathway.

PubMed ID: 24304693

DOI: 10.1111/gtc.12114

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 837
  • Mass: 96820
  • Checksum: F4C44F8411517289
  • Sequence:
    • MSLSHLYRDG EGRIDDDDDE RENFEITDWD LQNEFNPNRQ RHWQTKEEAT YGVWAERDSD 
DERPSFGGKR ARDYSAPVNF ISAGLKKGAA EEAELEDSDD EEKPVKQDDF PKDFGPRKLK 
TGGNFKPSQK GFAGGTKSFM DFGSWERHTK GIGQKLLQKM GYVPGRGLGK NAQGIINPIE 
AKQRKGKGAV GAYGSERTTQ SMQDFPVVDS EEEAEEEFQK ELSQWRKDPS GSKKKPKYSY 
KTVEELKAKG RISKKLTAPQ KELSQVKVID MTGREQKVYY SYSQISHKHN VPDDGLPLQS 
QQLPQSGKEA KAPGFALPEL EHNLQLLIDL TEQEIIQNDR QLQYERDMVV NLFHELEKMT 
EVLDHEERVI SNLSKVLEMV EECERRMQPD CSNPLTLDEC ARIFETLQDK YYEEYRMSDR 
VDLAVAIVYP LMKEYFKEWD PLKDCTYGTE IISKWKSLLE NDQLLSHGGQ DLSADAFHRL 
IWEVWMPFVR NIVTQWQPRN CDPMVDFLDS WVHIIPVWIL DNILDQLIFP KLQKEVENWN 
PLTDTVPIHS WIHPWLPLMQ ARLEPLYSPI RSKLSSALQK WHPSDSSAKL ILQPWKDVFT 
PGSWEAFMVK NIVPKLGMCL GELVINPHQQ HMDAFYWVID WEGMISVSSL VGLLEKHFFP 
KWLQVLCSWL SNSPNYEEIT KWYLGWKSMF SDQVLAHPSV KDKFNEALDI MNRAVSSNVG 
AYMQPGAREN IAYLTHTERR KDFQYEAMQE RREAENMAQR GIGVAASSVP MNFKDLIETK 
AEEHNIVFMP VIGKRHEGKQ LYTFGRIVIY IDRGVVFVQG EKTWVPTSLQ SLIDMAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.