Details for: PANX1

Gene ID: 24145

Symbol: PANX1

Ensembl ID: ENSG00000110218

Description: pannexin 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.18
    Marker Score: 2,407
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.1
    Marker Score: 373
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16,854
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.02
    Marker Score: 34,549
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,780
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,004
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.91
    Marker Score: 1,734
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,724
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,043
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,266
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.84
    Marker Score: 5,054
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.74
    Marker Score: 420
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 561
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.73
    Marker Score: 1,283
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 650
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 285
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.7
    Marker Score: 218
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,837
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.65
    Marker Score: 697
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 386
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.63
    Marker Score: 227
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.62
    Marker Score: 1,467
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.61
    Marker Score: 1,289
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.56
    Marker Score: 351
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.56
    Marker Score: 179
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.55
    Marker Score: 548
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.55
    Marker Score: 304
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 434
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 259
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.54
    Marker Score: 240
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.5
    Marker Score: 209
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.5
    Marker Score: 820
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5
    Marker Score: 734
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.49
    Marker Score: 543
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.48
    Marker Score: 309
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.48
    Marker Score: 108
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.46
    Marker Score: 1,121
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.45
    Marker Score: 111
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.44
    Marker Score: 408
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.44
    Marker Score: 111
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.43
    Marker Score: 457
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.43
    Marker Score: 15,975
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.43
    Marker Score: 366
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.43
    Marker Score: 1,583
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.43
    Marker Score: 239
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.42
    Marker Score: 4,313
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.42
    Marker Score: 108
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.4
    Marker Score: 497
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.4
    Marker Score: 496
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.4
    Marker Score: 383
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.39
    Marker Score: 1,549
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.38
    Marker Score: 216
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.38
    Marker Score: 146
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.38
    Marker Score: 405
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.37
    Marker Score: 438
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.37
    Marker Score: 156
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.37
    Marker Score: 331
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.37
    Marker Score: 117
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.36
    Marker Score: 2,148
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.36
    Marker Score: 104
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.36
    Marker Score: 1,460
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.36
    Marker Score: 135
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 235
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.35
    Marker Score: 854
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 91
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.34
    Marker Score: 886
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.33
    Marker Score: 1,384
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.33
    Marker Score: 479
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.32
    Marker Score: 71
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.32
    Marker Score: 400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.32
    Marker Score: 319
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.32
    Marker Score: 306
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.32
    Marker Score: 336
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.32
    Marker Score: 69
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.32
    Marker Score: 152
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.31
    Marker Score: 128
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.31
    Marker Score: 109
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.31
    Marker Score: 212
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.31
    Marker Score: 1,336
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.31
    Marker Score: 70
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.31
    Marker Score: 211
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.31
    Marker Score: 107
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.31
    Marker Score: 474
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.31
    Marker Score: 140
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.31
    Marker Score: 65
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.3
    Marker Score: 6,023
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.3
    Marker Score: 137
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.3
    Marker Score: 130
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.3
    Marker Score: 145
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.3
    Marker Score: 473
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.29
    Marker Score: 260
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.29
    Marker Score: 87

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PANX1 is a transmembrane protein with six transmembrane alpha-helices, which form a pore in the cell membrane. It is a member of the pannexin family, which is characterized by its ability to form channels in cell membranes. PANX1 is a calcium channel, allowing for the transport of calcium ions across cell membranes. It also exhibits leak channel activity, allowing for the passage of small molecules and ions. Additionally, PANX1 is a scaffold protein that interacts with other signaling molecules, modulating their activity. PANX1 is highly expressed in cells involved in immune responses, such as immature innate lymphoid cells and macrophages. It is also expressed in neurons, where it plays a role in neuronal communication and synaptic plasticity. PANX1 has been implicated in various diseases, including inflammatory disorders, such as arthritis and multiple sclerosis, as well as neurodegenerative diseases, such as Alzheimer's and Parkinson's. **Pathways and Functions** PANX1 is involved in various cellular pathways, including: 1. **Immune response**: PANX1 is a key player in the innate immune response, allowing for the exchange of ions and small molecules between immune cells, such as macrophages and dendritic cells. 2. **Neuronal communication**: PANX1 is involved in neuronal communication, allowing for the exchange of ions and small molecules between neurons. 3. **Calcium signaling**: PANX1 is a calcium channel, allowing for the transport of calcium ions across cell membranes. 4. **Inflammation**: PANX1 has been implicated in inflammatory disorders, such as arthritis and multiple sclerosis, where it modulates the activity of inflammatory signaling pathways. **Clinical Significance** PANX1 has been implicated in various diseases, including: 1. **Inflammatory disorders**: PANX1 has been implicated in inflammatory disorders, such as arthritis and multiple sclerosis, where it modulates the activity of inflammatory signaling pathways. 2. **Neurodegenerative diseases**: PANX1 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it modulates neuronal communication and synaptic plasticity. 3. **Cancer**: PANX1 has been implicated in cancer, where it modulates the activity of signaling pathways involved in cell proliferation and survival. 4. **Cardiovascular disease**: PANX1 has been implicated in cardiovascular disease, where it modulates the activity of signaling pathways involved in cardiac function and remodeling. In conclusion, PANX1 is a multifunctional protein that plays a critical role in various cellular processes, including cell-cell signaling, immune response, and neuronal communication. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of PANX1 function and its role in human disease.

Genular Protein ID: 3197437160

Symbol: PANX1_HUMAN

Name: Pannexin-1

UniProtKB Accession Codes:

Q96RD7 O75968 Q543A0 Q6UW26 Q96AM9 Q96L77 Q96RS5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 11 EMDB 23 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 27 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 19 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15028292

Title: The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins.

PubMed ID: 15028292

DOI: 10.1016/j.ygeno.2003.09.025

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16908669

Title: Functional implications of calcium permeability of the channel formed by pannexin 1.

PubMed ID: 16908669

DOI: 10.1083/jcb.200601115

PubMed ID: 17715132

Title: Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane.

PubMed ID: 17715132

DOI: 10.1074/jbc.m702422200

PubMed ID: 20829356

Title: Intracellular cysteine 346 is essentially involved in regulating Panx1 channel activity.

PubMed ID: 20829356

DOI: 10.1074/jbc.m110.101014

PubMed ID: 27129271

Title: A Germline Variant in the PANX1 Gene Has Reduced Channel Function and Is Associated with Multisystem Dysfunction.

PubMed ID: 27129271

DOI: 10.1074/jbc.m116.717934

PubMed ID: 30918116

Title: A pannexin 1 channelopathy causes human oocyte death.

PubMed ID: 30918116

DOI: 10.1126/scitranslmed.aav8731

Sequence Information:

  • Length: 426
  • Mass: 48050
  • Checksum: 368B48E0709424FB
  • Sequence:
    • MAIAQLATEY VFSDFLLKEP TEPKFKGLRL ELAVDKMVTC IAVGLPLLLI SLAFAQEISI 
GTQISCFSPS SFSWRQAAFV DSYCWAAVQQ KNSLQSESGN LPLWLHKFFP YILLLFAILL 
YLPPLFWRFA AAPHICSDLK FIMEELDKVY NRAIKAAKSA RDLDMRDGAC SVPGVTENLG 
QSLWEVSESH FKYPIVEQYL KTKKNSNNLI IKYISCRLLT LIIILLACIY LGYYFSLSSL 
SDEFVCSIKS GILRNDSTVP DQFQCKLIAV GIFQLLSVIN LVVYVLLAPV VVYTLFVPFR 
QKTDVLKVYE ILPTFDVLHF KSEGYNDLSL YNLFLEENIS EVKSYKCLKV LENIKSSGQG 
IDPMLLLTNL GMIKMDVVDG KTPMSAEMRE EQGNQTAELQ GMNIDSETKA NNGEKNARQR 
LLDSSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.