PANX1 | ENSG00000110218 | NCBI 24145

Details for: PANX1

Gene ID: 24145

Symbol: PANX1

Ensembl ID: ENSG00000110218

Description: pannexin 1

Associated with

Electric transmission across gap junctions
(R-HSA-112303)
Immune system
(R-HSA-168256)
Inflammasomes
(R-HSA-622312)
Innate immune system
(R-HSA-168249)
Neuronal system
(R-HSA-112316)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
The nlrp3 inflammasome
(R-HSA-844456)
Transmission across electrical synapses
(R-HSA-112307)
Actin filament binding
(GO:0051015)
Bleb
(GO:0032059)
Calcium channel activity
(GO:0005262)
Calcium ion transmembrane transport
(GO:0070588)
Calcium ion transport
(GO:0006816)
Cell-cell signaling
(GO:0007267)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Gap junction
(GO:0005921)
Gap junction hemi-channel activity
(GO:0055077)
Leak channel activity
(GO:0022840)
Membrane
(GO:0016020)
Monoatomic cation transport
(GO:0006812)
Oogenesis
(GO:0048477)
Plasma membrane
(GO:0005886)
Positive regulation of interleukin-1 alpha production
(GO:0032730)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of macrophage cytokine production
(GO:0060907)
Protease binding
(GO:0002020)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Response to atp
(GO:0033198)
Response to ischemia
(GO:0002931)
Scaffold protein binding
(GO:0097110)
Signaling receptor binding
(GO:0005102)
Structural molecule activity
(GO:0005198)
Transmembrane transporter binding
(GO:0044325)
Wide pore channel activity
(GO:0022829)

Other Information

Proteins

Pannexin-1

Genular Protein ID: 3197437160

Symbol: PANX1_HUMAN

Name: Pannexin-1

UniProtKB Accession Codes:

Q96RD7 O75968 Q543A0 Q6UW26 Q96AM9 Q96L77 Q96RS5

Database IDs:

Citations:

PubMed ID: 15028292

Title: The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins.

PubMed ID: 15028292

DOI: 10.1016/j.ygeno.2003.09.025

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16908669

Title: Functional implications of calcium permeability of the channel formed by pannexin 1.

PubMed ID: 16908669

DOI: 10.1083/jcb.200601115

PubMed ID: 17715132

Title: Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane.

PubMed ID: 17715132

DOI: 10.1074/jbc.m702422200

PubMed ID: 20829356

Title: Intracellular cysteine 346 is essentially involved in regulating Panx1 channel activity.

PubMed ID: 20829356

DOI: 10.1074/jbc.m110.101014

PubMed ID: 27129271

Title: A Germline Variant in the PANX1 Gene Has Reduced Channel Function and Is Associated with Multisystem Dysfunction.

PubMed ID: 27129271

DOI: 10.1074/jbc.m116.717934

PubMed ID: 30918116

Title: A pannexin 1 channelopathy causes human oocyte death.

PubMed ID: 30918116

DOI: 10.1126/scitranslmed.aav8731

Sequence Information:

Length: 426
Mass: 48050
Checksum: 368B48E0709424FB
Sequence:

MAIAQLATEY VFSDFLLKEP TEPKFKGLRL ELAVDKMVTC IAVGLPLLLI SLAFAQEISI 
GTQISCFSPS SFSWRQAAFV DSYCWAAVQQ KNSLQSESGN LPLWLHKFFP YILLLFAILL 
YLPPLFWRFA AAPHICSDLK FIMEELDKVY NRAIKAAKSA RDLDMRDGAC SVPGVTENLG 
QSLWEVSESH FKYPIVEQYL KTKKNSNNLI IKYISCRLLT LIIILLACIY LGYYFSLSSL 
SDEFVCSIKS GILRNDSTVP DQFQCKLIAV GIFQLLSVIN LVVYVLLAPV VVYTLFVPFR 
QKTDVLKVYE ILPTFDVLHF KSEGYNDLSL YNLFLEENIS EVKSYKCLKV LENIKSSGQG 
IDPMLLLTNL GMIKMDVVDG KTPMSAEMRE EQGNQTAELQ GMNIDSETKA NNGEKNARQR 
LLDSSC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PANX1

Associated with

Other Information

The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. PubMed ID: 15028292

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. PubMed ID: 16303743

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Functional implications of calcium permeability of the channel formed by pannexin 1. PubMed ID: 16908669

Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane. PubMed ID: 17715132

Intracellular cysteine 346 is essentially involved in regulating Panx1 channel activity. PubMed ID: 20829356

A Germline Variant in the PANX1 Gene Has Reduced Channel Function and Is Associated with Multisystem Dysfunction. PubMed ID: 27129271

A pannexin 1 channelopathy causes human oocyte death. PubMed ID: 30918116