Details for: CLDN15

Gene ID: 24146

Symbol: CLDN15

Ensembl ID: ENSG00000106404

Description: claudin 15

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.34
    Marker Score: 3,609
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.98
    Marker Score: 17,357
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.76
    Marker Score: 566
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.52
    Marker Score: 440
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.41
    Marker Score: 529
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.38
    Marker Score: 3,273
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.24
    Marker Score: 5,970
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.15
    Marker Score: 1,124
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.13
    Marker Score: 273
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.07
    Marker Score: 265
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,770
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.02
    Marker Score: 2,782
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1
    Marker Score: 1,000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,787
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,012
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,315
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,726
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.87
    Marker Score: 627
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.86
    Marker Score: 344
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,270
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.75
    Marker Score: 561
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.74
    Marker Score: 2,335
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 552
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.72
    Marker Score: 11,294
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 451
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.7
    Marker Score: 460
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 622
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.67
    Marker Score: 160
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.66
    Marker Score: 1,324
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.66
    Marker Score: 264
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.62
    Marker Score: 1,268
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6
    Marker Score: 2,516
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.57
    Marker Score: 543
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.55
    Marker Score: 3,311
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.55
    Marker Score: 237
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 430
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.54
    Marker Score: 140
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.54
    Marker Score: 1,355
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.53
    Marker Score: 904
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.51
    Marker Score: 236
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.51
    Marker Score: 1,082
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.51
    Marker Score: 266
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.51
    Marker Score: 241
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.48
    Marker Score: 840
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.48
    Marker Score: 164
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.47
    Marker Score: 136
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 0.47
    Marker Score: 145
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.46
    Marker Score: 145
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.44
    Marker Score: 309
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.44
    Marker Score: 184
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.44
    Marker Score: 116
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 263
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.44
    Marker Score: 725
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 182
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.43
    Marker Score: 117
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.41
    Marker Score: 93
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.41
    Marker Score: 169
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.41
    Marker Score: 365
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.41
    Marker Score: 142
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.4
    Marker Score: 270
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.4
    Marker Score: 630
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.4
    Marker Score: 192
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.39
    Marker Score: 492
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.39
    Marker Score: 244
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.39
    Marker Score: 467
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.38
    Marker Score: 75
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.38
    Marker Score: 81
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.38
    Marker Score: 153
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.36
    Marker Score: 150
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.36
    Marker Score: 339
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.36
    Marker Score: 324
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.35
    Marker Score: 342
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.35
    Marker Score: 87
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.35
    Marker Score: 831
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.35
    Marker Score: 182
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.35
    Marker Score: 93
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.35
    Marker Score: 129
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.34
    Marker Score: 358
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.33
    Marker Score: 129
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.32
    Marker Score: 731
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 142
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.32
    Marker Score: 87
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.31
    Marker Score: 443
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.31
    Marker Score: 1,254
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 307
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.3
    Marker Score: 151
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.29
    Marker Score: 143
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.28
    Marker Score: 539
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.28
    Marker Score: 66
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.28
    Marker Score: 161
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.28
    Marker Score: 416
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.28
    Marker Score: 134

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Claudin 15 exhibits several key characteristics that distinguish it from other claudins. These include: 1. **Calcium-independent cell-cell adhesion**: Claudin 15 is capable of mediating cell-cell adhesion in the absence of calcium, which is a characteristic that distinguishes it from other claudins. 2. **Monoatomic ion transport**: Claudin 15 is involved in the transport of monoatomic ions, such as sodium and chloride, across the plasma membrane. 3. **Lateral plasma membrane localization**: Claudin 15 is primarily localized to the lateral plasma membrane, where it interacts with other proteins to form tight junctions. 4. **Structural molecule activity**: Claudin 15 contributes to the structural integrity of tight junctions, providing a scaffold for the assembly of other proteins and molecules. **Pathways and Functions** Claudin 15 is involved in several key pathways and functions, including: 1. **Bicellular tight junction assembly**: Claudin 15 plays a critical role in the assembly of tight junctions between adjacent epithelial cells. 2. **Cell-cell communication**: Claudin 15 facilitates the exchange of signaling molecules between cells, allowing for the coordination of cellular processes such as differentiation and proliferation. 3. **Cell adhesion**: Claudin 15 contributes to the formation of cell-cell adhesions, which are essential for maintaining tissue integrity and preventing the invasion of pathogens. 4. **Monoatomic ion transport**: Claudin 15 regulates the transport of monoatomic ions across the plasma membrane, which is critical for maintaining proper ion balance and cellular homeostasis. **Clinical Significance** Claudin 15 has been implicated in several diseases and disorders, including: 1. **Inflammatory bowel disease**: Claudin 15 has been shown to be downregulated in patients with inflammatory bowel disease, suggesting that it may play a role in the development of this condition. 2. **Cancer**: Claudin 15 has been found to be overexpressed in certain types of cancer, including colon and pancreatic cancer, suggesting that it may contribute to tumorigenesis. 3. **Cardiovascular disease**: Claudin 15 has been implicated in the development of cardiovascular disease, possibly due to its role in regulating blood pressure and fluid balance. In conclusion, claudin 15 is a critical component of tight junctions in epithelial cells, contributing to cell-cell adhesion, communication, and ion transport. Its dysregulation has been implicated in several diseases and disorders, highlighting the importance of this gene in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 1854173770

Symbol: CLD15_HUMAN

Name: Claudin-15

UniProtKB Accession Codes:

P56746 B3KPB5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12055082

Title: Claudins create charge-selective channels in the paracellular pathway between epithelial cells.

PubMed ID: 12055082

DOI: 10.1152/ajpcell.00038.2002

PubMed ID: 13129853

Title: Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins.

PubMed ID: 13129853

DOI: 10.1152/ajprenal.00116.2003

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 228
  • Mass: 24356
  • Checksum: D502E2CD9116F4B1
  • Sequence:
    • MSMAVETFGF FMATVGLLML GVTLPNSYWR VSTVHGNVIT TNTIFENLWF SCATDSLGVY 
NCWEFPSMLA LSGYIQACRA LMITAILLGF LGLLLGIAGL RCTNIGGLEL SRKAKLAATA 
GALHILAGIC GMVAISWYAF NITRDFFDPL YPGTKYELGP ALYLGWSASL ISILGGLCLC 
SACCCGSDED PAASARRPYQ APVSVMPVAT SDQEGDSSFG KYGRNAYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.