Details for: FJX1

Gene ID: 24147

Symbol: FJX1

Ensembl ID: ENSG00000179431

Description: four-jointed box kinase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,160
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.39
    Marker Score: 6,846
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.37
    Marker Score: 1,364
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,800
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7,426
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,792
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,034
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.98
    Marker Score: 11,091
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,321
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.91
    Marker Score: 3,525
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.89
    Marker Score: 601
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,283
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.86
    Marker Score: 357
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.82
    Marker Score: 1,550
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.81
    Marker Score: 373
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.8
    Marker Score: 3,354
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,254
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 567
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.73
    Marker Score: 25,423
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.72
    Marker Score: 1,465
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.71
    Marker Score: 4,620
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.69
    Marker Score: 10,725
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.68
    Marker Score: 2,673
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.61
    Marker Score: 614
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.59
    Marker Score: 334
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.58
    Marker Score: 367
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.56
    Marker Score: 18,995
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.55
    Marker Score: 1,342
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.55
    Marker Score: 1,030
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 348
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 256
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.51
    Marker Score: 177
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.51
    Marker Score: 208
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.49
    Marker Score: 205
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.49
    Marker Score: 143
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.49
    Marker Score: 330
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.47
    Marker Score: 4,881
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.47
    Marker Score: 150
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.47
    Marker Score: 166
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.47
    Marker Score: 232
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 258
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.43
    Marker Score: 479
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.42
    Marker Score: 645
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.4
    Marker Score: 192
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.39
    Marker Score: 250
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.39
    Marker Score: 544
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.38
    Marker Score: 330
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.38
    Marker Score: 179
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.37
    Marker Score: 1,947
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.37
    Marker Score: 88
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.37
    Marker Score: 142
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.35
    Marker Score: 546
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.35
    Marker Score: 87
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.35
    Marker Score: 87
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 91
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.34
    Marker Score: 114
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.34
    Marker Score: 20,635
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.33
    Marker Score: 330
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.32
    Marker Score: 275
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.32
    Marker Score: 82
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.32
    Marker Score: 240
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.31
    Marker Score: 295
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.31
    Marker Score: 296
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.31
    Marker Score: 97
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.31
    Marker Score: 320
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.31
    Marker Score: 725
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.31
    Marker Score: 421
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.3
    Marker Score: 521
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.29
    Marker Score: 135
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.29
    Marker Score: 143
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.29
    Marker Score: 261
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.29
    Marker Score: 61
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.28
    Marker Score: 122
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 123
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.28
    Marker Score: 247
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.27
    Marker Score: 241
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.27
    Marker Score: 91
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.27
    Marker Score: 191
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.27
    Marker Score: 389
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.27
    Marker Score: 137
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.26
    Marker Score: 140
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.26
    Marker Score: 91
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.26
    Marker Score: 151
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.26
    Marker Score: 64
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.26
    Marker Score: 163

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine/threonine kinase activity**: FJX1 possesses intrinsic kinase activity, enabling it to phosphorylate and regulate downstream targets. 2. **Cellular expression**: FJX1 is expressed in various cell types, including colon goblet cells, myoepithelial cells, enterocytes, and GABAergic interneurons. 3. **Tissue specificity**: FJX1's expression patterns suggest its involvement in tissue-specific processes, such as retinal layer development and intestinal homeostasis. 4. **Multifunctional protein**: FJX1's involvement in multiple cellular processes, including signaling, cell-cell interactions, and tissue development, highlights its versatility and importance in cellular regulation. **Pathways and Functions:** 1. **Cell-cell signaling**: FJX1's kinase activity enables it to regulate signaling pathways, including those involved in cell-cell interactions, adhesion, and migration. 2. **Extracellular space formation**: FJX1's expression in enterocytes and goblet cells suggests its role in extracellular matrix assembly and formation of the epithelial barrier. 3. **Retina layer development**: FJX1's involvement in retinal layer development highlights its importance in the formation and maintenance of the retinal epithelium. 4. **GABAergic signaling**: FJX1's expression in GABAergic interneurons underscores its role in regulating GABAergic neurotransmission and synaptic plasticity. **Clinical Significance:** 1. **Intestinal disorders**: FJX1's involvement in intestinal homeostasis and barrier function suggests its potential role in the pathogenesis of intestinal disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). 2. **Cancer**: FJX1's expression in various cancer types, including colon and breast cancer, highlights its potential as a biomarker or therapeutic target. 3. **Neurological disorders**: FJX1's involvement in GABAergic signaling and synaptic plasticity suggests its potential role in the pathogenesis of neurological disorders, such as epilepsy and schizophrenia. 4. **Regenerative medicine**: FJX1's expression in stem cells and progenitor cells suggests its potential role in tissue regeneration and repair. In conclusion, FJX1 is a multifunctional protein with diverse roles in cellular signaling, tissue development, and organogenesis. Further research is necessary to fully elucidate its mechanisms of action and clinical significance, but its involvement in various cellular processes underscores its importance in maintaining tissue homeostasis and promoting health.

Genular Protein ID: 2943752586

Symbol: FJX1_HUMAN

Name: Four-jointed box protein 1

UniProtKB Accession Codes:

Q86VR8 B2RCA9 Q9UGK6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10568747

Title: A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1.

PubMed ID: 10568747

DOI: 10.1101/gr.9.11.1074

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 437
  • Mass: 48507
  • Checksum: 3E2B8D3977722639
  • Sequence:
    • MGRRMRGAAA TAGLWLLALG SLLALWGGLL PPRTELPASR PPEDRLPRRP ARSGGPAPAP 
RFPLPPPLAW DARGGSLKTF RALLTLAAGA DGPPRQSRSE PRWHVSARQP RPEESAAVHG 
GVFWSRGLEE QVPPGFSEAQ AAAWLEAARG ARMVALERGG CGRSSNRLAR FADGTRACVR 
YGINPEQIQG EALSYYLARL LGLQRHVPPL ALARVEARGA QWAQVQEELR AAHWTEGSVV 
SLTRWLPNLT DVVVPAPWRS EDGRLRPLRD AGGELANLSQ AELVDLVQWT DLILFDYLTA 
NFDRLVSNLF SLQWDPRVMQ RATSNLHRGP GGALVFLDNE AGLVHGYRVA GMWDKYNEPL 
LQSVCVFRER TARRVLELHR GQDAAARLLR LYRRHEPRFP ELAALADPHA QLLQRRLDFL 
AKHILHCKAK YGRRSGT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.