Details for: PRPF6
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: oogonial cell (CL0000024)
Fold Change: 1.93
Marker Score: 2,770 - Cell Name: blood cell (CL0000081)
Fold Change: 1.75
Marker Score: 20,341 - Cell Name: male germ cell (CL0000015)
Fold Change: 1.72
Marker Score: 496 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.67
Marker Score: 12,449 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.61
Marker Score: 2,017 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.56
Marker Score: 13,589 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.54
Marker Score: 811 - Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.52
Marker Score: 1,103 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.51
Marker Score: 5,573 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.5
Marker Score: 3,162 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.45
Marker Score: 3,026 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.45
Marker Score: 2,134 - Cell Name: ependymal cell (CL0000065)
Fold Change: 1.45
Marker Score: 505 - Cell Name: plasmablast (CL0000980)
Fold Change: 1.44
Marker Score: 1,915 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.41
Marker Score: 12,417 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.41
Marker Score: 5,532 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.4
Marker Score: 418 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.39
Marker Score: 696 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.39
Marker Score: 929 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.39
Marker Score: 2,275 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.38
Marker Score: 1,547 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.38
Marker Score: 7,236 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.36
Marker Score: 3,110 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.36
Marker Score: 1,643 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.35
Marker Score: 1,429 - Cell Name: Unknown (CL0002371)
Fold Change: 1.35
Marker Score: 1,431 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.34
Marker Score: 2,283 - Cell Name: basal cell (CL0000646)
Fold Change: 1.34
Marker Score: 1,728 - Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.34
Marker Score: 2,620 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.33
Marker Score: 1,223 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.33
Marker Score: 731 - Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.32
Marker Score: 425 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.32
Marker Score: 1,036 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.32
Marker Score: 3,593 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.31
Marker Score: 1,323 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.31
Marker Score: 313 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.3
Marker Score: 14,659 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.29
Marker Score: 2,458 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.28
Marker Score: 8,323 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.27
Marker Score: 1,322 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.27
Marker Score: 2,255 - Cell Name: Leydig cell (CL0000178)
Fold Change: 1.27
Marker Score: 1,371 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.27
Marker Score: 393 - Cell Name: neural crest cell (CL0011012)
Fold Change: 1.26
Marker Score: 1,350 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.25
Marker Score: 294 - Cell Name: Unknown (CL0000548)
Fold Change: 1.25
Marker Score: 912 - Cell Name: keratinocyte (CL0000312)
Fold Change: 1.25
Marker Score: 1,043 - Cell Name: ciliated cell (CL0000064)
Fold Change: 1.25
Marker Score: 4,292 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.24
Marker Score: 577 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.22
Marker Score: 7,264 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.22
Marker Score: 1,286 - Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.22
Marker Score: 427 - Cell Name: oocyte (CL0000023)
Fold Change: 1.22
Marker Score: 301 - Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.21
Marker Score: 1,174 - Cell Name: keratocyte (CL0002363)
Fold Change: 1.21
Marker Score: 279 - Cell Name: neural cell (CL0002319)
Fold Change: 1.21
Marker Score: 584 - Cell Name: supporting cell (CL0000630)
Fold Change: 1.21
Marker Score: 2,274 - Cell Name: proerythroblast (CL0000547)
Fold Change: 1.21
Marker Score: 819 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.2
Marker Score: 12,084 - Cell Name: pro-T cell (CL0000827)
Fold Change: 1.2
Marker Score: 4,905 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.2
Marker Score: 1,611 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 1.19
Marker Score: 3,404 - Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 1.19
Marker Score: 501 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.19
Marker Score: 797 - Cell Name: adventitial cell (CL0002503)
Fold Change: 1.19
Marker Score: 293 - Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.18
Marker Score: 1,113 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.18
Marker Score: 12,206 - Cell Name: memory B cell (CL0000787)
Fold Change: 1.18
Marker Score: 894 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.17
Marker Score: 281 - Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.17
Marker Score: 1,268 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.16
Marker Score: 7,079 - Cell Name: pro-B cell (CL0000826)
Fold Change: 1.16
Marker Score: 1,123 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.16
Marker Score: 568 - Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 1.16
Marker Score: 531 - Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.16
Marker Score: 2,068 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.16
Marker Score: 471 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.15
Marker Score: 2,716 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.14
Marker Score: 1,620 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.14
Marker Score: 39,519 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 1.14
Marker Score: 1,143 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.14
Marker Score: 11,519 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.13
Marker Score: 14,923 - Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.13
Marker Score: 380 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.13
Marker Score: 846 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.13
Marker Score: 1,061 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.12
Marker Score: 766 - Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 1.12
Marker Score: 687 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.12
Marker Score: 3,039 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.12
Marker Score: 2,232 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.12
Marker Score: 4,819 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.12
Marker Score: 322 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.11
Marker Score: 529 - Cell Name: enteric neuron (CL0007011)
Fold Change: 1.11
Marker Score: 592 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.11
Marker Score: 705 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.11
Marker Score: 68,280 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.1
Marker Score: 10,484 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.1
Marker Score: 752 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.1
Marker Score: 474 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.1
Marker Score: 4,703 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.09
Marker Score: 9,381
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 986103776
Symbol: PRP6_HUMAN
Name: Pre-mRNA-processing factor 6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10561546
Title: A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors.
PubMed ID: 10561546
PubMed ID: 10788320
Title: The human homologue of the yeast splicing factor Prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions.
PubMed ID: 10788320
PubMed ID: 10848612
Title: Isoform-specific localization of A-RAF in mitochondria.
PubMed ID: 10848612
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 12039962
Title: Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor.
PubMed ID: 12039962
PubMed ID: 11991638
Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
PubMed ID: 11991638
PubMed ID: 16723661
Title: The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.
PubMed ID: 16723661
DOI: 10.1261/rna.55406
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 34023904
Title: SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes.
PubMed ID: 34023904
DOI: 10.1093/nar/gkab386
PubMed ID: 26912367
Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.
PubMed ID: 26912367
PubMed ID: 28781166
Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
PubMed ID: 28781166
PubMed ID: 21549338
Title: A missense mutation in PRPF6 causes impairment of pre-mRNA splicing and autosomal-dominant retinitis pigmentosa.
PubMed ID: 21549338
PubMed ID: 22235333
Title: Mutations in the gene DNAJC5 cause autosomal dominant Kufs disease in a proportion of cases: study of the Parry family and 8 other families.
PubMed ID: 22235333
Sequence Information:
- Length: 941
- Mass: 106925
- Checksum: 91C2F1ADCA439BE9
- Sequence:
MNKKKKPFLG MPAPLGYVPG LGRGATGFTT RSDIGPARDA NDPVDDRHAP PGKRTVGDQM KKNQAADDDD EDLNDTNYDE FNGYAGSLFS SGPYEKDDEE ADAIYAALDK RMDERRKERR EQREKEEIEK YRMERPKIQQ QFSDLKRKLA EVTEEEWLSI PEVGDARNKR QRNPRYEKLT PVPDSFFAKH LQTGENHTSV DPRQTQFGGL NTPYPGGLNT PYPGGMTPGL MTPGTGELDM RKIGQARNTL MDMRLSQVSD SVSGQTVVDP KGYLTDLNSM IPTHGGDIND IKKARLLLKS VRETNPHHPP AWIASARLEE VTGKLQVARN LIMKGTEMCP KSEDVWLEAA RLQPGDTAKA VVAQAVRHLP QSVRIYIRAA ELETDIRAKK RVLRKALEHV PNSVRLWKAA VELEEPEDAR IMLSRAVECC PTSVELWLAL ARLETYENAR KVLNKARENI PTDRHIWITA AKLEEANGNT QMVEKIIDRA ITSLRANGVE INREQWIQDA EECDRAGSVA TCQAVMRAVI GIGIEEEDRK HTWMEDADSC VAHNALECAR AIYAYALQVF PSKKSVWLRA AYFEKNHGTR ESLEALLQRA VAHCPKAEVL WLMGAKSKWL AGDVPAARSI LALAFQANPN SEEIWLAAVK LESENDEYER ARRLLAKARS SAPTARVFMK SVKLEWVQDN IRAAQDLCEE ALRHYEDFPK LWMMKGQIEE QKEMMEKARE AYNQGLKKCP HSTPLWLLLS RLEEKIGQLT RARAILEKSR LKNPKNPGLW LESVRLEYRA GLKNIANTLM AKALQECPNS GILWSEAIFL EARPQRRTKS VDALKKCEHD PHVLLAVAKL FWSQRKITKA REWFHRTVKI DSDLGDAWAF FYKFELQHGT EEQQEEVRKR CESAEPRHGE LWCAVSKDIA NWQKKIGDIL RLVAGRIKNT F
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.