Details for: ZNF318

Gene ID: 24149

Symbol: ZNF318

Ensembl ID: ENSG00000171467

Description: zinc finger protein 318

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron (CL0000540)
    Fold Change: 1.64
    Marker Score: 6,673
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.63
    Marker Score: 12,464
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.58
    Marker Score: 23,600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.51
    Marker Score: 93,034
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.5
    Marker Score: 29,832
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.48
    Marker Score: 56,247
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.45
    Marker Score: 53,627
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.45
    Marker Score: 12,484
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.43
    Marker Score: 13,616
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.42
    Marker Score: 13,373
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.41
    Marker Score: 2,029
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.34
    Marker Score: 5,557
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.33
    Marker Score: 5,132
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.31
    Marker Score: 2,017
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.28
    Marker Score: 27,252
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.26
    Marker Score: 12,987
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16,492
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.05
    Marker Score: 1,315
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.05
    Marker Score: 2,128
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.01
    Marker Score: 926
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1
    Marker Score: 2,358
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,755
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,980
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.98
    Marker Score: 2,904
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.94
    Marker Score: 842
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.93
    Marker Score: 267
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.92
    Marker Score: 1,938
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,720
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.9
    Marker Score: 409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,001
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.82
    Marker Score: 495
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.81
    Marker Score: 799
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.79
    Marker Score: 3,660
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 574
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3,109
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.74
    Marker Score: 593
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.73
    Marker Score: 898
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.71
    Marker Score: 175
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 618
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.67
    Marker Score: 1,916
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.67
    Marker Score: 768
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.64
    Marker Score: 1,541
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.64
    Marker Score: 316
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.63
    Marker Score: 204
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.62
    Marker Score: 20,789
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.61
    Marker Score: 530
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.61
    Marker Score: 3,655
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.61
    Marker Score: 144
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.59
    Marker Score: 720
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.59
    Marker Score: 2,467
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.59
    Marker Score: 392
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.58
    Marker Score: 578
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.58
    Marker Score: 1,269
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.57
    Marker Score: 179
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.55
    Marker Score: 1,890
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.55
    Marker Score: 276
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.55
    Marker Score: 4,794
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 430
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.53
    Marker Score: 325
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.53
    Marker Score: 229
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 337
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.53
    Marker Score: 357
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.52
    Marker Score: 304
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.52
    Marker Score: 249
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.52
    Marker Score: 199
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.52
    Marker Score: 290
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.51
    Marker Score: 298
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.51
    Marker Score: 335
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.51
    Marker Score: 148
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.5
    Marker Score: 844
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.5
    Marker Score: 332
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.5
    Marker Score: 201
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.5
    Marker Score: 488
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.5
    Marker Score: 954
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.5
    Marker Score: 598
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.49
    Marker Score: 182
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.47
    Marker Score: 312
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.47
    Marker Score: 2,513
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.47
    Marker Score: 444
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.47
    Marker Score: 230
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.46
    Marker Score: 500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.46
    Marker Score: 618
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.46
    Marker Score: 346
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.44
    Marker Score: 153
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 184
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.44
    Marker Score: 1,469
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.44
    Marker Score: 474
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.43
    Marker Score: 4,398
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.43
    Marker Score: 3,201

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc finger domain:** ZNF318 contains a characteristic zinc finger domain, which is essential for its DNA-binding activity and protein homodimerization. 2. **Transcriptional regulation:** ZNF318 is involved in the regulation of gene expression through its ability to bind to DNA and form homodimers, thereby modulating transcriptional activity. 3. **Neuronal specificity:** ZNF318 is significantly expressed in neuronal populations, including GABAergic cortical interneurons and glutamatergic cortical neurons, suggesting its role in neuronal development and function. 4. **Cell type specificity:** ZNF318 exhibits cell-type-specific expression patterns, highlighting its potential involvement in specific neuronal functions. **Pathways and Functions:** 1. **Negative regulation of DNA-templated transcription:** ZNF318 can act as a repressor of transcription, inhibiting the expression of specific genes involved in neuronal development and function. 2. **Positive regulation of DNA-templated transcription:** ZNF318 can also act as an activator of transcription, promoting the expression of genes involved in neuronal development and function. 3. **Cytosol and nucleoplasm:** ZNF318 is localized to both the cytosol and nucleoplasm, suggesting its involvement in both nuclear and cytoplasmic processes. 4. **Zinc ion binding:** The zinc finger domain of ZNF318 allows it to bind to zinc ions, which is essential for its DNA-binding activity and protein homodimerization. **Clinical Significance:** 1. **Neurological disorders:** ZNF318's involvement in neuronal development and function makes it a potential candidate for studying the molecular mechanisms underlying neurological disorders, such as autism spectrum disorder and epilepsy. 2. **Neurodevelopmental disorders:** The expression patterns of ZNF318 in specific neuronal populations suggest its potential involvement in neurodevelopmental disorders, such as Rett syndrome and Fragile X syndrome. 3. **Cancer:** The transcriptional regulatory activity of ZNF318 may also be involved in cancer development and progression, particularly in tumors with neuronal or glial components. 4. **Therapeutic potential:** Understanding the function and regulation of ZNF318 may lead to the development of novel therapeutic strategies for neurological disorders and cancer. In conclusion, the Zinc Finger Protein 318 (ZNF318) gene plays a critical role in regulating gene expression in neuronal populations, and its dysregulation may contribute to various neurological disorders. Further studies are necessary to elucidate the molecular mechanisms underlying ZNF318's function and to explore its therapeutic potential.

Genular Protein ID: 1866773279

Symbol: ZN318_HUMAN

Name: Zinc finger protein 318

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9853615

Title: Selection system for genes encoding nuclear-targeted proteins.

PubMed ID: 9853615

DOI: 10.1038/4315

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 2279
  • Mass: 251112
  • Checksum: CC8F7D54710E2450
  • Sequence:
  • MYRSSARSSV SSHRPKDDGG GGPRSGRSSG SSSGPARRSS PPPPPSGSSS RTPARRPRSP 
    SGHRGRRASP SPPRGRRVSP SPPRARRGSP SPPRGRRLFP PGPAGFRGSS RGESRADYAR 
    DGRGDHPGDS GSRRRSPGLC SDSLEKSLRI TVGNDHFCVS TPERRRLSDR LGSPVDNLED 
    MDRDDLTDDS VFTRSSQCSR GLERYISQEE GPLSPFLGQL DEDYRTKETF LHRSDYSPHI 
    SCHDELLRGT ERNREKLKGY SIRSEERSRE AKRPRYDDTV KINSMGGDHP SFTSGTRNYR 
    QRRRSPSPRF LDPEFRELDL ARRKREEEEE RSRSLSQELV GVDGGGTGCS IPGLSGVLTA 
    SEPGYSLHRP EEVSVMPKKS ILKKRIEVDI MEPSMQLESF SSSTSSSQDH PLYSGHPSLP 
    LSGAIAAFAS EIENKGTMVE TALKEPQGNL YQWGPLPGIP KDNSPLREKF GSFLCHKDNL 
    DLKAEGPERH TDFLLPHERA SQDGSGFSRI LSMLADSTST QEKRRRSFPD IEDEEKFLYG 
    DEEEDLKAES VPKPLGSSES EVMRQKASSL PSSAPAVKLE SLEETNPEYA KIHDLLKTIG 
    LDIGVAEISQ LAARTQERLH GKKPSLRSSA DRRSSVDRYF SADHCSSVDH RFSADRCSSV 
    DHCFSADRRS SDPHRLESRE AHHSNTHSPE VSHPHPPSPV DPYLLTKNSP PFLKSDHPVG 
    HISGPEVVGS GFQSSVAVRC MLPSAPSAPI RLPHTAALSQ FHMPRASQFA AARIPPNYQG 
    PAIPPASFDA YRHYMAYAAS RWPMYPTSQP SNHPVPEPHR IMPITKQATR SRPNLRVIPT 
    VTPDKPKQKE SLRGSIPAAQ VPVQVSIPSL IRYNPEKISD EKNRASQKQK VIEEREKLKN 
    DREARQKKMY YLRTELERLH KQQGEMLRKK RREKDGHKDP LLVEVSRLQD NIMKDIAELR 
    QEAEEAEKKQ SELDKVAQIL GINIFDKSQK SLSDSREPTE KPGKAEKSKS PEKVSSFSNS 
    SSNKESKVNN EKFRTKSPKP AESPQSATKQ LDQPTAAYEY YDAGNHWCKD CNTICGTMFD 
    FFTHMHNKKH TQTLDPYNRP WASKTQSEAK QDAIKRTDKI TVPAKGSEFL VPISGFYCQL 
    CEEFLGDPIS GEQHVKGHQH NEKYKKYVDE NPLYEERRNL DRQAGLAVVL ETERRRQSEL 
    KRKLSEKPKE EKKEKKAKAV KEVKEDDKVS EKLEDQLSEG RNSPEKAENK RNTGIKLQLK 
    EEVKKESPTS SSFGKFSWKK PEKEEEKSSL VTPSISKEEI LESSKDKEDG KTEAGKAKPI 
    KIKLSGKTVV AHTSPWMPVV TTSTQTKIRP NLPIPSTVLR KSCSATMSKP APLNTFLSIK 
    SSGTTAKPLP VVKESSADLL LPPDIISKAF GGEEVILKGS PEEKVVLAEK SEPSHLPEQI 
    LPPPPPPPPP PPPPPPVIPH PAAPSAAQAN AILAPVKSNP VVSQTLSPGF VGPNILNPVL 
    PVAIMASAQP AAIPSDETAP GVSESDRDQT LFSVLVRPPP PLSSVFSEQA KKLEKRNSCL 
    ATANAKDLYD IFYSSGGKGA PETKGAPETK LSGGPLANGE NSNLSRTKSS DTSSTSPLNS 
    SASQEELHQD EGLVAAPIVS NSEKPIAKTL VALGKWSVVE HVGPKSTGST YGFLQPLTRL 
    CQSRPYETIT PKTDTLAIWT SSSFQSDTSR DISPEKSELD LGEPGPPGVE PPPQLLDIQC 
    KESQKLVEIH LRESVNQDKE SQELRKSEDC RESEIETNTE LKERVKELSE GIVDEGVSTS 
    IGPHSIDDSN LNHGNRYMWE GEVKQPNLLM IDKEAEQSNK LMTGSETPSK VVIKLSPQAC 
    SFTKAKLDSF LSEARSLLNP QDTPVKISAP ELLLHSPARS AMCLTGSPQE QGVSVVSEEG 
    LENSAPESAS RTSRYRSLKL KRERSKDFQV KKIYELAVWD ENKKRPETWE SPEKPKTEAL 
    ELQDVHPELT VTIESKALED FEATDLKVEE LTALGNLGDM PVDFCTTRVS PAHRSPTVLC 
    QKVCEENSVS PIGCNSSDPA DFEPIPSFSG FPLDSPKTLV LDFETEGERN SPNPRSVRIP 
    SPNILKTGLT ENVDRGLGGL EGTHQALDLL AGGMMPEEVK ESSQLDKQES LGLELKTINS 
    AGLGPSPCLP DLVDFVTRTS GVQKDKLCSP LSEPGDPSKC SSLELGPLQL EISNASTTEV 
    AILQVDDDSG DPLNLVKAPV SRSPPREQVI EDNMVPQGMP EQETTVGAIQ DHTESSVHN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.