Genular: Defining Cellular Identity and Function

Details for: A2m

Gene ID: 24153

Symbol: A2m

Ensembl ID: ENSRNOG00000028896

Description: alpha-2-macroglobulin

Associated with

Degradation of the extracellular matrix
(R-RNO-1474228)
Extracellular matrix organization
(R-RNO-1474244)
Formation of fibrin clot (clotting cascade)
(R-RNO-140877)
Hdl assembly
(R-RNO-8963896)
Hemostasis
(R-RNO-109582)
Intrinsic pathway of fibrin clot formation
(R-RNO-140837)
Plasma lipoprotein assembly
(R-RNO-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-RNO-174824)
Platelet activation, signaling and aggregation
(R-RNO-76002)
Platelet degranulation
(R-RNO-114608)
Response to elevated platelet cytosolic ca2+
(R-RNO-76005)
Transport of small molecules
(R-RNO-382551)
Acute-phase response
(GO:0006953)
Acute inflammatory response to antigenic stimulus
(GO:0002438)
Brain-derived neurotrophic factor binding
(GO:0048403)
Calcium-dependent protein binding
(GO:0048306)
Embryonic liver development
(GO:1990402)
Endopeptidase inhibitor activity
(GO:0004866)
Enzyme binding
(GO:0019899)
Extracellular space
(GO:0005615)
Growth factor binding
(GO:0019838)
Identical protein binding
(GO:0042802)
Interleukin-1 binding
(GO:0019966)
Interleukin-8 binding
(GO:0019959)
Luteinization
(GO:0001553)
Negative regulation of complement activation, lectin pathway
(GO:0001869)
Nerve growth factor binding
(GO:0048406)
Protease binding
(GO:0002020)
Response to carbon dioxide
(GO:0010037)
Response to glucocorticoid
(GO:0051384)
Response to nutrient
(GO:0007584)
Response to prostaglandin e
(GO:0034695)
Serine-type endopeptidase inhibitor activity
(GO:0004867)
Signaling receptor binding
(GO:0005102)
Stem cell differentiation
(GO:0048863)
Tumor necrosis factor binding
(GO:0043120)

Other Information

Proteins

Alpha-2-macroglobulin

Genular Protein ID: 3219554087

Symbol: A2MG_RAT

Name: Alpha-2-macroglobulin

UniProtKB Accession Codes:

P06238 Q4FZY3

Database IDs:

Citations:

PubMed ID: 2432068

Title: Sequence of rat liver alpha 2-macroglobulin and acute phase control of its messenger RNA.

PubMed ID: 2432068

DOI: 10.1016/s0021-9258(19)75947-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2466233

Title: Identification of the promoter sequences involved in the interleukin-6 dependent expression of the rat alpha 2-macroglobulin gene.

PubMed ID: 2466233

DOI: 10.1093/nar/17.3.1121

PubMed ID: 2414291

Title: Molecular cloning of DNA complementary to rat alpha 2-macroglobulin mRNA.

PubMed ID: 2414291

DOI: 10.1016/s0021-9258(17)38706-9

PubMed ID: 1725450

Title: Sequence of rat alpha 1-macroglobulin, a broad-range proteinase inhibitor from the alpha-macroglobulin-complement family.

PubMed ID: 1725450

Sequence Information:

Length: 1472
Mass: 163785
Checksum: BFD63B8A4F6A2632
Sequence:

MGKHRLRSLA LLPLLLRLLL LLLPTDASAP QKPIYMVMVP SLLHAGTPEK ACFLFSHLNE 
TVAVRVSLES VRGNQSLFTD LVVDKDLFHC TSFTVPQSSS DEVMFFTVQV KGATHEFRRR 
STVLVKKKES LVFAQTDKPI YKPGQTVRFR VVSLDESFHP LNELIPLLYI QDPKNNRIAQ 
WQNFNLEGGL KQLSFPLSSE PTQGSYKVVI RTESGRTVEH PFSVEEFVLP KFEVRVTVPE 
TITILEEEMN VSVCGIYTYG KPVPGRVTVN ICRKYSNPSN CFGEESVAFC EKLSQQLDGR 
GCFSQLVKTK SFQLKRQEYE MQLDVHAKIQ EEGTGVEETG KGLTKITRTI TKLSFVNVDS 
HFRQGIPFVG QVLLVDGRGT PIPYETIFIG ADEANLYINT TTDKHGLARF SINTDDIMGT 
SLTVRAKYKD SNACYGFRWL TEENVEAWHT AYAVFSPSRS FLHLESLPDK LRCDQTLEVQ 
AHYILNGEAM QELKELVFYY LMMAKGGIVR AGTHVLPLKQ GQMRGHFSIL ISMETDLAPV 
ARLVLYAILP NGEVVGDTAK YEIENCLANK VDLVFRPNSG LPATRALLSV MASPQSLCGL 
RAVDQSVLLM KPETELSASL IYDLLPVKDL TGFPQGADQR EEDTNGCVKQ NDTYINGILY 
SPVQNTNEED MYGFLKDMGL KVFTNSNIRK PKVCERLRDN KGIPAAYHLV SQSHMDAFLE 
SSESPTETRR SYFPETWIWD LVVVDSAGVA EVEVTVPDTI TEWKAGAFCL SNDTGLGLSP 
VVQFQAFQPF FVELTMPYSV IRGEAFTLKA TVLNYLPTCI RVAVQLEASP DFLAAPEEKE 
QRSHCICMNQ RHTASWAVIP KSLGNVNFTV SAEALNSKEL CGNEVPVVPE QGKKDTIIKS 
LLVEPEGLEN EVTFNSLLCP MGAEVSELIA LKLPSDVVEE SARASVTVLG DILGSAMQNT 
QDLLKMPYGC GEQNMVLFAP NIYVLDYLNE TQQLTQEIKT KAIAYLNTGY QRQLNYKHRD 
GSYSTFGDKP GRNHANTWLT AFVLKSFAQA RKYIFIDEVH ITQALLWLSQ QQKDNGCFRS 
SGSLLNNAMK GGVEDEVTLS AYITIALLEM SLPVTHPVVR NALFCLDTAW KSARGGAGGS 
HVYTKALLAY AFALAGNQDT KKEILKSLDE EAVKEEDSVH WTRPQKPSVS VALWYQPQAP 
SAEVEMTAYV LLAYLTTEPA PTQEDLTAAM LIVKWLTKQQ NSHGGFSSTQ DTVVALHALS 
KYGSATFTRA KKAAQVTIHS SGTFSTKFQV NNNNQLLLQR VTLPTVPGDY TVKVTGEGCV 
YLQTSLKYSV LPREEEFPFT VVVQTLPGTC EDPKAHTSFQ ISLNISYTGS RSESNMAIAD 
VKMVSGFIPL KPTVKMLERS VHVSRTEVSN NHVLIYLDKV SNQTVNLSFT VQQDIPIRDL 
KPAVVKVYDY YEKDEFAVAK YSAPCSTDYG NA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: A2m

Associated with

Other Information

Sequence of rat liver alpha 2-macroglobulin and acute phase control of its messenger RNA. PubMed ID: 2432068

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of the promoter sequences involved in the interleukin-6 dependent expression of the rat alpha 2-macroglobulin gene. PubMed ID: 2466233