Details for: Adcyap1

Gene ID: 24166

Symbol: Adcyap1

Ensembl ID: ENSRNOG00000049882

Description: adenylate cyclase activating polypeptide 1

Associated with

  • Class b/2 (secretin family receptors)
    (R-RNO-373080)
  • Glucagon-type ligand receptors
    (R-RNO-420092)
  • Gpcr ligand binding
    (R-RNO-500792)
  • Signaling by gpcr
    (R-RNO-372790)
  • Signal transduction
    (R-RNO-162582)
  • Adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0007189)
  • Behavioral fear response
    (GO:0001662)
  • Camp-mediated signaling
    (GO:0019933)
  • Cellular response to glucocorticoid stimulus
    (GO:0071385)
  • Cytosol
    (GO:0005829)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Histamine secretion
    (GO:0001821)
  • Insulin secretion
    (GO:0030073)
  • Negative regulation of acute inflammatory response to antigenic stimulus
    (GO:0002865)
  • Negative regulation of acute inflammatory response to non-antigenic stimulus
    (GO:0002878)
  • Negative regulation of cell cycle
    (GO:0045786)
  • Negative regulation of glial cell proliferation
    (GO:0060253)
  • Negative regulation of muscle cell apoptotic process
    (GO:0010656)
  • Negative regulation of potassium ion transport
    (GO:0043267)
  • Neuron projection
    (GO:0043005)
  • Neuron projection development
    (GO:0031175)
  • Neuropeptide hormone activity
    (GO:0005184)
  • Neuropeptide signaling pathway
    (GO:0007218)
  • Ovarian follicle development
    (GO:0001541)
  • Peptide hormone receptor binding
    (GO:0051428)
  • Perikaryon
    (GO:0043204)
  • Pituitary adenylate cyclase-activating polypeptide receptor binding
    (GO:0031858)
  • Pituitary adenylate cyclase activating polypeptide activity
    (GO:0016521)
  • Pituitary gland development
    (GO:0021983)
  • Positive regulation of camp-mediated signaling
    (GO:0043950)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of chemokine (c-c motif) ligand 5 production
    (GO:0071651)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of growth hormone secretion
    (GO:0060124)
  • Positive regulation of gtpase activity
    (GO:0043547)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of neuron projection development
    (GO:0010976)
  • Positive regulation of protein kinase activity
    (GO:0045860)
  • Positive regulation of somatostatin secretion
    (GO:0090274)
  • Positive regulation of synaptic transmission, glutamatergic
    (GO:0051968)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of g protein-coupled receptor signaling pathway
    (GO:0008277)
  • Regulation of oligodendrocyte progenitor proliferation
    (GO:0070445)
  • Regulation of postsynaptic membrane potential
    (GO:0060078)
  • Regulation of protein localization
    (GO:0032880)
  • Regulation of protein phosphorylation
    (GO:0001932)
  • Response to ethanol
    (GO:0045471)
  • Response to starvation
    (GO:0042594)
  • Signaling receptor binding
    (GO:0005102)
  • Terminal bouton
    (GO:0043195)
  • Vasodilation
    (GO:0042311)

Other Information

Genular Protein ID: 3631528158

Symbol: PACA_RAT

Name: Pituitary adenylate cyclase-activating polypeptide

UniProtKB Accession Codes:

P13589

Database IDs:

AGR 1 AlphaFoldDB 1 BMRB 1 Bgee 1 BindingDB 1 CTD 1 EMBL 2 Ensembl 4 ExpressionAtlas 1 GO 49 Gene3D 1 GeneTree 1 Genevisible 1 InParanoid 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 1 RefSeq 5 SMART 1 SMR 1 STRING 1 UniProtKB 3 eggNOG 1

Citations:

PubMed ID: 2268329

Title: Molecular cloning and characterization of cDNA for the precursor of rat pituitary adenylate cyclase activating polypeptide (PACAP).

PubMed ID: 2268329

DOI: 10.1016/s0006-291x(05)80924-6

PubMed ID: 7835287

Title: Cloning and molecular characterization of complementary deoxyribonucleic acid corresponding to a novel form of pituitary adenylate cyclase-activating polypeptide messenger ribonucleic acid in the rat testis.

PubMed ID: 7835287

DOI: 10.1210/endo.136.2.7835287

PubMed ID: 2803320

Title: Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells.

PubMed ID: 2803320

DOI: 10.1016/0006-291x(89)91757-9

PubMed ID: 18198219

Title: Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion.

PubMed ID: 18198219

DOI: 10.1096/fj.06-075820

PubMed ID: 23800469

Title: Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells.

PubMed ID: 23800469

DOI: 10.1126/scisignal.2003993

Sequence Information:

  • Length: 175
  • Mass: 19557
  • Checksum: 0398946896602B04
  • Sequence:
    • MTMCSGARLA LLVYGIIMHN SVSCSPAAGL SFPGIRPEEE AYDQDGNPLQ DFYDWDPPGA 
GSPASALRDA YALYYPADRR DVAHEILNEA YRKVLDQLSA RKYLQSMVAR GMGENLAAAA 
VDDRAPLTKR HSDGIFTDSY SRYRKQMAVK KYLAAVLGKR YKQRVKNKGR RIAYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.