Details for: Agt

Gene ID: 24179

Symbol: Agt

Ensembl ID: ENSRNOG00000018445

Description: angiotensinogen

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-RNO-373076)
  • G alpha (i) signalling events
    (R-RNO-418594)
  • G alpha (q) signalling events
    (R-RNO-416476)
  • Gpcr downstream signalling
    (R-RNO-388396)
  • Gpcr ligand binding
    (R-RNO-500792)
  • Metabolism of angiotensinogen to angiotensins
    (R-RNO-2022377)
  • Metabolism of proteins
    (R-RNO-392499)
  • Peptide hormone metabolism
    (R-RNO-2980736)
  • Peptide ligand-binding receptors
    (R-RNO-375276)
  • Signaling by gpcr
    (R-RNO-372790)
  • Signal transduction
    (R-RNO-162582)
  • Aldosterone secretion
    (GO:0035932)
  • Angiotensin-activated signaling pathway
    (GO:0038166)
  • Angiotensin-mediated drinking behavior
    (GO:0003051)
  • Angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
    (GO:0001998)
  • Artery smooth muscle contraction
    (GO:0014824)
  • Associative learning
    (GO:0008306)
  • Astrocyte activation
    (GO:0048143)
  • Blood vessel development
    (GO:0001568)
  • Brain renin-angiotensin system
    (GO:0002035)
  • Branching involved in ureteric bud morphogenesis
    (GO:0001658)
  • Cell-matrix adhesion
    (GO:0007160)
  • Cell population proliferation
    (GO:0008283)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Drinking behavior
    (GO:0042756)
  • Establishment of blood-nerve barrier
    (GO:0008065)
  • Extracellular matrix organization
    (GO:0030198)
  • Female pregnancy
    (GO:0007565)
  • Fibroblast proliferation
    (GO:0048144)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Hormone activity
    (GO:0005179)
  • Hormone metabolic process
    (GO:0042445)
  • Intracellular sodium ion homeostasis
    (GO:0006883)
  • Kidney development
    (GO:0001822)
  • Maintenance of blood vessel diameter homeostasis by renin-angiotensin
    (GO:0002034)
  • Mapk cascade
    (GO:0000165)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of cell growth
    (GO:0030308)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of tissue remodeling
    (GO:0034104)
  • Operant conditioning
    (GO:0035106)
  • Organ growth
    (GO:0035265)
  • Ovarian follicle rupture
    (GO:0001543)
  • Peristalsis
    (GO:0030432)
  • Positive regulation of blood pressure
    (GO:0045777)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cardiac muscle cell apoptotic process
    (GO:0010666)
  • Positive regulation of cardiac muscle hypertrophy
    (GO:0010613)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of endothelial cell migration
    (GO:0010595)
  • Positive regulation of epidermal growth factor receptor signaling pathway
    (GO:0045742)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Positive regulation of extracellular matrix constituent secretion
    (GO:0003331)
  • Positive regulation of fatty acid biosynthetic process
    (GO:0045723)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of macrophage derived foam cell differentiation
    (GO:0010744)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of multicellular organism growth
    (GO:0040018)
  • Positive regulation of neuron projection development
    (GO:0010976)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of organ growth
    (GO:0046622)
  • Positive regulation of peptidyl-serine phosphorylation
    (GO:0033138)
  • Positive regulation of superoxide anion generation
    (GO:0032930)
  • Protein import into nucleus
    (GO:0006606)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of blood pressure
    (GO:0008217)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of heart rate
    (GO:0002027)
  • Regulation of norepinephrine secretion
    (GO:0014061)
  • Regulation of renal output by angiotensin
    (GO:0002019)
  • Regulation of systemic arterial blood pressure by circulatory renin-angiotensin
    (GO:0001991)
  • Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
    (GO:0001999)
  • Renal system process
    (GO:0003014)
  • Renin-angiotensin regulation of aldosterone production
    (GO:0002018)
  • Response to cold
    (GO:0009409)
  • Response to estradiol
    (GO:0032355)
  • Response to mechanical stimulus
    (GO:0009612)
  • Response to muscle activity involved in regulation of muscle adaptation
    (GO:0014873)
  • Response to salt stress
    (GO:0009651)
  • Serine-type endopeptidase inhibitor activity
    (GO:0004867)
  • Sodium channel regulator activity
    (GO:0017080)
  • Type 1 angiotensin receptor binding
    (GO:0031702)
  • Type 2 angiotensin receptor binding
    (GO:0031703)
  • Vasoconstriction
    (GO:0042310)
  • Vasodilation
    (GO:0042311)
  • Vasopressin secretion
    (GO:0030103)

Other Information

Genular Protein ID: 574825416

Symbol: ANGT_RAT

Name: Angiotensinogen

UniProtKB Accession Codes:

P01015

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BindingDB 1 BioGRID 1 CDD 1 CTD 1 EMBL 6 EvolutionaryTrace 1 GO 100 Gene3D 2 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 7 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 4 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 6572971

Title: Cloning and sequence analysis of cDNA for rat angiotensinogen.

PubMed ID: 6572971

DOI: 10.1073/pnas.80.8.2196

PubMed ID: 6330095

Title: Common structural organization of the angiotensinogen and the alpha 1-antitrypsin genes.

PubMed ID: 6330095

DOI: 10.1016/s0021-9258(17)39689-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4344907

Title: Comparative studies on angiotensins. II. Structure of rat angiotensin and its identification by DNS-method.

PubMed ID: 4344907

DOI: 10.1248/cpb.20.1579

PubMed ID: 9508787

Title: Molecular characterization of a dual endothelin-1/Angiotensin II receptor.

PubMed ID: 9508787

DOI: 10.1007/bf03401733

PubMed ID: 18026570

Title: The antithrombotic effect of angiotensin-(1-7) involves mas-mediated NO release from platelets.

PubMed ID: 18026570

DOI: 10.2119/2007-00073.fraga-silva

PubMed ID: 20927107

Title: A redox switch in angiotensinogen modulates angiotensin release.

PubMed ID: 20927107

DOI: 10.1038/nature09505

Sequence Information:

  • Length: 477
  • Mass: 51982
  • Checksum: 689051A5788D693D
  • Sequence:
    • MTPTGAGLKA TIFCILTWVS LTAGDRVYIH PFHLLYYSKS TCAQLENPSV ETLPEPTFEP 
VPIQAKTSPV DEKTLRDKLV LATEKLEAED RQRAAQVAMI ANFMGFRMYK MLSEARGVAS 
GAVLSPPALF GTLVSFYLGS LDPTASQLQV LLGVPVKEGD CTSRLDGHKV LTALQAVQGL 
LVTQGGSSSQ TPLLQSTVVG LFTAPGLRLK QPFVESLGPF TPAIFPRSLD LSTDPVLAAQ 
KINRFVQAVT GWKMNLPLEG VSTDSTLFFN TYVHFQGKMR GFSQLTGLHE FWVDNSTSVS 
VPMLSGTGNF QHWSDAQNNF SVTRVPLGES VTLLLIQPQC ASDLDRVEVL VFQHDFLTWI 
KNPPPRAIRL TLPQLEIRGS YNLQDLLAQA KLSTLLGAEA NLGKMGDTNP RVGEVLNSIL 
LELQAGEEEQ PTESAQQPGS PEVLDVTLSS PFLFAIYERD SGALHFLGRV DNPQNVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.