Genular: Defining Cellular Identity and Function

Details for: Agtr1a

Gene ID: 24180

Symbol: Agtr1a

Ensembl ID: ENSRNOG00000018346

Description: angiotensin II receptor, type 1a

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-RNO-8856825)
Class a/1 (rhodopsin-like receptors)
(R-RNO-373076)
Clathrin-mediated endocytosis
(R-RNO-8856828)
G alpha (q) signalling events
(R-RNO-416476)
Gpcr downstream signalling
(R-RNO-388396)
Gpcr ligand binding
(R-RNO-500792)
Membrane trafficking
(R-RNO-199991)
Peptide ligand-binding receptors
(R-RNO-375276)
Signaling by gpcr
(R-RNO-372790)
Signal transduction
(R-RNO-162582)
Vesicle-mediated transport
(R-RNO-5653656)
Angiotensin-activated signaling pathway
(GO:0038166)
Angiotensin type ii receptor activity
(GO:0004945)
Angiotensin type i receptor activity
(GO:0001596)
Basolateral plasma membrane
(GO:0016323)
Blood vessel development
(GO:0001568)
Bradykinin receptor binding
(GO:0031711)
Brain renin-angiotensin system
(GO:0002035)
Calcium-mediated signaling
(GO:0019722)
Cell chemotaxis
(GO:0060326)
Cellular response to dexamethasone stimulus
(GO:0071549)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
D1 dopamine receptor binding
(GO:0031748)
Dendrite
(GO:0030425)
Dopamine biosynthetic process
(GO:0042416)
Drinking behavior
(GO:0042756)
Endosome
(GO:0005768)
Gene expression
(GO:0010467)
Golgi apparatus
(GO:0005794)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heart development
(GO:0007507)
Inflammatory response
(GO:0006954)
Kidney development
(GO:0001822)
Maintenance of blood vessel diameter homeostasis by renin-angiotensin
(GO:0002034)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of smooth muscle cell apoptotic process
(GO:0034392)
Neuron apoptotic process
(GO:0051402)
Organelle outer membrane
(GO:0031968)
Phospholipase c-activating angiotensin-activated signaling pathway
(GO:0086097)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of blood pressure
(GO:0045777)
Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:1903589)
Positive regulation of branching involved in ureteric bud morphogenesis
(GO:0090190)
Positive regulation of calcium ion import across plasma membrane
(GO:1905665)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of macrophage derived foam cell differentiation
(GO:0010744)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of receptor recycling
(GO:0001921)
Positive regulation of superoxide anion generation
(GO:0032930)
Positive regulation of vascular associated smooth muscle cell proliferation
(GO:1904707)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein kinase binding
(GO:0019901)
Recycling endosome
(GO:0055037)
Regulation of blood pressure
(GO:0008217)
Regulation of ph
(GO:0006885)
Regulation of renal output by angiotensin
(GO:0002019)
Regulation of systemic arterial blood pressure by circulatory renin-angiotensin
(GO:0001991)
Regulation of vascular associated smooth muscle cell apoptotic process
(GO:1905459)
Regulation of vasoconstriction
(GO:0019229)
Renin-angiotensin regulation of aldosterone production
(GO:0002018)
Renin secretion into blood stream
(GO:0002001)
Response to activity
(GO:0014823)
Response to angiotensin
(GO:1990776)
Response to corticosterone
(GO:0051412)
Response to estrogen
(GO:0043627)
Response to salt stress
(GO:0009651)
Rho protein signal transduction
(GO:0007266)
Vascular associated smooth muscle cell proliferation
(GO:1990874)
Vasoconstriction
(GO:0042310)

Other Information

Proteins

AGTRA_RAT

Genular Protein ID: 870643437

Symbol: AGTRA_RAT

Name: N/A

UniProtKB Accession Codes:

P25095 Q9QVS5

Database IDs:

Citations:

PubMed ID: 2041570

Title: Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor.

PubMed ID: 2041570

DOI: 10.1038/351233a0

PubMed ID: 2043116

Title: Rat angiotensin II receptor: cDNA sequence and regulation of the gene expression.

PubMed ID: 2043116

DOI: 10.1016/0006-291x(91)91982-i

PubMed ID: 1533121

Title: The genomic organization of the rat AT1 angiotensin receptor.

PubMed ID: 1533121

DOI: 10.1016/s0006-291x(05)80293-1

PubMed ID: 1544458

Title: Identification of two subtypes in the rat type I angiotensin II receptor.

PubMed ID: 1544458

DOI: 10.1016/0014-5793(92)80071-n

PubMed ID: 7713098

Title: Cloning, expression and regulation of angiotensin II receptors.

PubMed ID: 7713098

DOI: 10.1093/eurheartj/15.suppl_d.104

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1599457

Title: Characterization of an angiotensin type-1 receptor partial cDNA from rat kidney: evidence for a novel AT1B receptor subtype.

PubMed ID: 1599457

DOI: 10.1016/s0006-291x(05)80976-3

PubMed ID: 10747880

Title: Activation of the AT1 angiotensin receptor is dependent on adjacent apolar residues in the carboxyl terminus of the third cytoplasmic loop.

PubMed ID: 10747880

DOI: 10.1074/jbc.m000198200

PubMed ID: 11579203

Title: Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization.

PubMed ID: 11579203

DOI: 10.1210/mend.15.10.0714

Sequence Information:

Length: 359
Mass: 40890
Checksum: 200EAE56DB4DA678
Sequence:

MALNSSAEDG IKRIQDDCPK AGRHSYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK 
TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL CKIASASVSF NLYASVFLLT 
CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLMAGLAS LPAVIHRNVY FIENTNITVC 
AFHYESRNST LPIGLGLTKN ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFR 
IIMAIVLFFF FSWVPHQIFT FLDVLIQLGV IHDCKISDIV DTAMPITICI AYFNNCLNPL 
FYGFLGKKFK KYFLQLLKYI PPKAKSHSSL STKMSTLSYR PSDNMSSSAK KPASCFEVE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Agtr1a

Associated with

Other Information

Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. PubMed ID: 2041570

Rat angiotensin II receptor: cDNA sequence and regulation of the gene expression. PubMed ID: 2043116

The genomic organization of the rat AT1 angiotensin receptor. PubMed ID: 1533121

Identification of two subtypes in the rat type I angiotensin II receptor. PubMed ID: 1544458

Cloning, expression and regulation of angiotensin II receptors. PubMed ID: 7713098

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of an angiotensin type-1 receptor partial cDNA from rat kidney: evidence for a novel AT1B receptor subtype. PubMed ID: 1599457

Activation of the AT1 angiotensin receptor is dependent on adjacent apolar residues in the carboxyl terminus of the third cytoplasmic loop. PubMed ID: 10747880

Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization. PubMed ID: 11579203