Details for: Agtr2

Gene ID: 24182

Symbol: Agtr2

Ensembl ID: ENSRNOG00000050006

Description: angiotensin II receptor, type 2

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-RNO-373076)
  • G alpha (i) signalling events
    (R-RNO-418594)
  • Gpcr downstream signalling
    (R-RNO-388396)
  • Gpcr ligand binding
    (R-RNO-500792)
  • Peptide ligand-binding receptors
    (R-RNO-375276)
  • Signaling by gpcr
    (R-RNO-372790)
  • Signal transduction
    (R-RNO-162582)
  • Angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure
    (GO:0002033)
  • Angiotensin type ii receptor activity
    (GO:0004945)
  • Brain renin-angiotensin system
    (GO:0002035)
  • Cell growth involved in cardiac muscle cell development
    (GO:0061049)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Cellular response to dexamethasone stimulus
    (GO:0071549)
  • Cerebellar cortex development
    (GO:0021695)
  • Dopamine biosynthetic process
    (GO:0042416)
  • Exploration behavior
    (GO:0035640)
  • G-protein alpha-subunit binding
    (GO:0001965)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • G protein-coupled receptor signaling pathway coupled to cgmp nucleotide second messenger
    (GO:0007199)
  • Inflammatory response
    (GO:0006954)
  • Intracellular signal transduction
    (GO:0035556)
  • Intracellular sodium ion homeostasis
    (GO:0006883)
  • Kidney development
    (GO:0001822)
  • Kidney morphogenesis
    (GO:0060993)
  • Negative regulation of fibroblast proliferation
    (GO:0048147)
  • Negative regulation of heart rate
    (GO:0010459)
  • Negative regulation of icosanoid secretion
    (GO:0032304)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of neurotrophin trk receptor signaling pathway
    (GO:0051387)
  • Negative regulation of norepinephrine secretion
    (GO:0010700)
  • Neuron apoptotic process
    (GO:0051402)
  • Neuron differentiation
    (GO:0030182)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of branching involved in ureteric bud morphogenesis
    (GO:0090190)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of extrinsic apoptotic signaling pathway
    (GO:2001238)
  • Positive regulation of metanephric glomerulus development
    (GO:0072300)
  • Protein binding
    (GO:0005515)
  • Regulation of metanephros size
    (GO:0035566)
  • Regulation of protein import into nucleus
    (GO:0042306)
  • Regulation of systemic arterial blood pressure by circulatory renin-angiotensin
    (GO:0001991)
  • Renin-angiotensin regulation of aldosterone production
    (GO:0002018)
  • Response to organonitrogen compound
    (GO:0010243)
  • Vasodilation
    (GO:0042311)

Other Information

Genular Protein ID: 3441344375

Symbol: AGTR2_RAT

Name: N/A

UniProtKB Accession Codes:

P35351

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BindingDB 1 BioGRID 1 CDD 1 CTD 1 ChEBI 7 ChEMBL 1 DrugCentral 1 EMBL 4 Ensembl 7 ExpressionAtlas 1 GO 39 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 2 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 UniProtKB 2 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8227011

Title: Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.

PubMed ID: 8227011

DOI: 10.1016/s0021-9258(19)74499-8

PubMed ID: 8227010

Title: Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.

PubMed ID: 8227010

DOI: 10.1016/s0021-9258(19)74498-6

PubMed ID: 7490161

Title: Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene.

PubMed ID: 7490161

DOI: 10.1161/01.hyp.26.6.998

PubMed ID: 7713098

Title: Cloning, expression and regulation of angiotensin II receptors.

PubMed ID: 7713098

DOI: 10.1093/eurheartj/15.suppl_d.104

PubMed ID: 7599191

Title: Cloning of the rat angiotensin II type 2 receptor gene and identification of its functional promoter region.

PubMed ID: 7599191

DOI: 10.1016/0167-4781(95)00076-s

PubMed ID: 11068047

Title: Reversible inactivation of AT(2) angiotensin II receptor from cysteine-disulfide bond exchange.

PubMed ID: 11068047

DOI: 10.1016/s0014-5793(00)02141-4

Sequence Information:

  • Length: 363
  • Mass: 41331
  • Checksum: 4FE4551A41336650
  • Sequence:
    • MKDNFSFAAT SRNITSSLPF DNLNATGTNE SAFNCSHKPA DKHLEAIPVL YYMIFVIGFA 
VNIVVVSLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW ATYYSYRYDW LFGPVMCKVF 
GSFLTLNMFA SIFFITCMSV DRYQSVIYPF LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY 
FRDVRTIEYL GVNACIMAFP PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK 
TNSYGKNRIT RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL 
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR KSSSLREMDT 
FVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.