Akt1 | ENSRNOG00000028629 | NCBI 24185

Details for: Akt1

Gene ID: 24185

Symbol: Akt1

Ensembl ID: ENSRNOG00000028629

Description: AKT serine/threonine kinase 1

Associated with

14-3-3 protein binding
(GO:0071889)
Activation-induced cell death of t cells
(GO:0006924)
Apoptotic mitochondrial changes
(GO:0008637)
Atp binding
(GO:0005524)
Calmodulin binding
(GO:0005516)
Canonical nf-kappab signal transduction
(GO:0007249)
Carbohydrate transport
(GO:0008643)
Cell migration involved in sprouting angiogenesis
(GO:0002042)
Cell projection organization
(GO:0030030)
Cellular response to decreased oxygen levels
(GO:0036294)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to reactive oxygen species
(GO:0034614)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Dna damage response
(GO:0006974)
Enzyme binding
(GO:0019899)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Gene expression
(GO:0010467)
Germ cell development
(GO:0007281)
Glucose metabolic process
(GO:0006006)
Glycogen biosynthetic process
(GO:0005978)
Glycogen metabolic process
(GO:0005977)
Gtpase activating protein binding
(GO:0032794)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Insulin receptor signaling pathway
(GO:0008286)
Interleukin-18-mediated signaling pathway
(GO:0035655)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Mammalian oogenesis stage
(GO:0022605)
Maternal placenta development
(GO:0001893)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of fatty acid beta-oxidation
(GO:0031999)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of long-chain fatty acid import across plasma membrane
(GO:0010748)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of superoxide anion generation
(GO:0032929)
Nitric-oxide synthase regulator activity
(GO:0030235)
Osteoblast differentiation
(GO:0001649)
Peptidyl-serine phosphorylation
(GO:0018105)
Peripheral nervous system myelin maintenance
(GO:0032287)
Phosphatidylinositol-3,4,5-trisphosphate binding
(GO:0005547)
Phosphatidylinositol-3,4-bisphosphate binding
(GO:0043325)
Phosphorylation
(GO:0016310)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of fibroblast migration
(GO:0010763)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glucose metabolic process
(GO:0010907)
Positive regulation of mitochondrial membrane potential
(GO:0010918)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of sodium ion transport
(GO:0010765)
Potassium channel activator activity
(GO:0099104)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein homodimerization activity
(GO:0042803)
Protein import into nucleus
(GO:0006606)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein kinase c binding
(GO:0005080)
Protein phosphatase 2a binding
(GO:0051721)
Protein serine/threonine/tyrosine kinase activity
(GO:0004712)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine/threonine kinase binding
(GO:0120283)
Protein serine/threonine kinase inhibitor activity
(GO:0030291)
Protein serine kinase activity
(GO:0106310)
Protein ubiquitination
(GO:0016567)
Regulation of cell migration
(GO:0030334)
Regulation of glycogen biosynthetic process
(GO:0005979)
Regulation of myelination
(GO:0031641)
Regulation of neuron projection development
(GO:0010975)
Regulation of protein localization
(GO:0032880)
Regulation of translation
(GO:0006417)
Response to fluid shear stress
(GO:0034405)
Response to food
(GO:0032094)
Response to heat
(GO:0009408)
Response to hormone
(GO:0009725)
Response to ischemia
(GO:0002931)
Response to organic substance
(GO:0010033)
Response to oxidative stress
(GO:0006979)
Sphingosine-1-phosphate receptor signaling pathway
(GO:0003376)
Spinal cord development
(GO:0021510)
Translation
(GO:0006412)

Other Information

Proteins

RAC-alpha serine/threonine-protein kinase

Genular Protein ID: 2326358616

Symbol: AKT1_RAT

Name: RAC-alpha serine/threonine-protein kinase

UniProtKB Accession Codes:

P47196

Database IDs:

Citations:

PubMed ID: 7999118

Title: Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta.

PubMed ID: 7999118

DOI: 10.1006/bbrc.1994.2738

PubMed ID: 9632753

Title: Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport.

PubMed ID: 9632753

DOI: 10.1128/mcb.18.7.3708

PubMed ID: 10400692

Title: Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1).

PubMed ID: 10400692

DOI: 10.1074/jbc.274.29.20611

PubMed ID: 11882383

Title: The protein kinase B/Akt signalling pathway in human malignancy.

PubMed ID: 11882383

DOI: 10.1016/s0898-6568(01)00271-6

PubMed ID: 12107176

Title: The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes.

PubMed ID: 12107176

DOI: 10.1074/jbc.m204681200

PubMed ID: 15546921

Title: Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles.

PubMed ID: 15546921

DOI: 10.1242/jcs.01517

PubMed ID: 16832058

Title: Ebp1 isoforms distinctively regulate cell survival and differentiation.

PubMed ID: 16832058

DOI: 10.1073/pnas.0602923103

PubMed ID: 21620960

Title: Akt signalling in health and disease.

PubMed ID: 21620960

DOI: 10.1016/j.cellsig.2011.05.004

PubMed ID: 21432781

Title: Akt1 and Akt2: differentiating the aktion.

PubMed ID: 21432781

DOI: 10.14670/hh-26.651

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 480
Mass: 55735
Checksum: 5DCAAE7134366D04
Sequence:

MNDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVEQRES PLNNFSVAQC 
QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT TAIQTVADGL KRQEEETMDF 
RSGSPSDNSG AEEMEVALAK PKHRVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI 
LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS 
RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI 
KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL 
ILMEEIRFPR TLGPEAKSLL SGLLKKDPTQ RLGGGSEDAK EIMQHRFFAN IVWQDVYEKK 
LSPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDSMEC VDSERRPHFP QFSYSASGTA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Akt1

Associated with

Other Information

Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta. PubMed ID: 7999118

Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport. PubMed ID: 9632753

Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1). PubMed ID: 10400692

The protein kinase B/Akt signalling pathway in human malignancy. PubMed ID: 11882383

The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes. PubMed ID: 12107176

Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles. PubMed ID: 15546921

Ebp1 isoforms distinctively regulate cell survival and differentiation. PubMed ID: 16832058

Akt signalling in health and disease. PubMed ID: 21620960

Akt1 and Akt2: differentiating the aktion. PubMed ID: 21432781

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903