Genular: Defining Cellular Identity and Function

Details for: Aldh1a1

Gene ID: 24188

Symbol: Aldh1a1

Ensembl ID: ENSRNOG00000017619

Description: aldehyde dehydrogenase 1 family, member A1

Associated with

Biological oxidations
(R-RNO-211859)
Ethanol oxidation
(R-RNO-71384)
Fructose catabolism
(R-RNO-70350)
Fructose metabolism
(R-RNO-5652084)
Metabolism
(R-RNO-1430728)
Metabolism of carbohydrates
(R-RNO-71387)
Phase i - functionalization of compounds
(R-RNO-211945)
Ra biosynthesis pathway
(R-RNO-5365859)
Signaling by nuclear receptors
(R-RNO-9006931)
Signaling by retinoic acid
(R-RNO-5362517)
Signal transduction
(R-RNO-162582)
3-chloroallyl aldehyde dehydrogenase activity
(GO:0004028)
3-deoxyglucosone dehydrogenase activity
(GO:0106373)
9-cis-retinoic acid biosynthetic process
(GO:0042904)
9-cis-retinoic acid metabolic process
(GO:0042905)
Aldehyde dehydrogenase (nad+) activity
(GO:0004029)
Aminobutyraldehyde dehydrogenase activity
(GO:0019145)
Apoptotic process
(GO:0006915)
Axon
(GO:0030424)
Benzaldehyde dehydrogenase (nad+) activity
(GO:0018479)
Cellular detoxification of aldehyde
(GO:0110095)
Cytosol
(GO:0005829)
Embryonic eye morphogenesis
(GO:0048048)
Estrous cycle
(GO:0044849)
Fructosamine catabolic process
(GO:0030392)
Fructose catabolic process
(GO:0006001)
Gamma-aminobutyric acid biosynthetic process
(GO:0009449)
Glyceraldehyde-3-phosphate dehydrogenase (nad+) (non-phosphorylating) activity
(GO:0043878)
Identical protein binding
(GO:0042802)
Kidney development
(GO:0001822)
Liver development
(GO:0001889)
Maintenance of lens transparency
(GO:0036438)
Midgut development
(GO:0007494)
Nad binding
(GO:0051287)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Optic cup morphogenesis involved in camera-type eye development
(GO:0002072)
Oxidoreductase activity, acting on the aldehyde or oxo group of donors, nad or nadp as acceptor
(GO:0016620)
Positive regulation of apoptotic process
(GO:0043065)
Response to estradiol
(GO:0032355)
Response to ethanol
(GO:0045471)
Response to organic cyclic compound
(GO:0014070)
Response to oxidative stress
(GO:0006979)
Response to retinoic acid
(GO:0032526)
Response to xenobiotic stimulus
(GO:0009410)
Retinal dehydrogenase activity
(GO:0001758)
Retinoic acid biosynthetic process
(GO:0002138)
Retinoic acid metabolic process
(GO:0042573)
Retinoid metabolic process
(GO:0001523)
Retinol metabolic process
(GO:0042572)
Synapse
(GO:0045202)

Other Information

Proteins

ALDH-E1

Genular Protein ID: 1411784960

Symbol: AL1A1_RAT

Name: ALDH-E1

UniProtKB Accession Codes:

P51647 O09184

Database IDs:

Citations:

PubMed ID: 8543180

Title: Cloning of a cDNA encoding rat aldehyde dehydrogenase with high activity for retinal oxidation.

PubMed ID: 8543180

DOI: 10.1016/0378-1119(96)81752-5

PubMed ID: 9059608

Title: A preliminary report on the cloning of a constitutively expressed rat liver cytosolic ALDH cDNA by PCR.

PubMed ID: 9059608

DOI: 10.1007/978-1-4615-5871-2_9

PubMed ID: 9240474

Title: Cloning of a cDNA encoding a constitutively expressed rat liver cytosolic aldehyde dehydrogenase.

PubMed ID: 9240474

DOI: 10.1006/bbrc.1997.6998

PubMed ID: 9218716

Title: Cloning of a rat cDNA encoding retinal dehydrogenase isozyme type I and its expression in E. coli.

PubMed ID: 9218716

DOI: 10.1016/s0378-1119(97)00054-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7832787

Title: A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid.

PubMed ID: 7832787

DOI: 10.1042/bj3050681

PubMed ID: 15623782

Title: Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress.

PubMed ID: 15623782

DOI: 10.1167/iovs.04-0120

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 501
Mass: 54459
Checksum: A3614C21BCE7E144
Sequence:

MSSPAQPAVP APLANLKIQH TKIFINNEWH DSVSGKKFPV LNPATEEVIC HVEEGDKADV 
DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLMERDR LLLATIEAIN GGKVFANAYL 
SDLGGSIKAL KYCAGWADKI HGQTIPSDGD IFTFTRREPI GVCGQIIPWN FPLLMFIWKI 
GPALSCGNTV VVKPAEQTPL TALHMASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDVD 
KVAFTGSTQV GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDIAVEF AHHGVFYHQG 
QCCVAASRIF VEESVYDEFV RKSVERAKKY VLGNPLTQGI NQGPQIDKEQ HDKILDLIES 
GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSIDDVIKR 
ANNTTYGLAA GVFTKDLDRA ITVSSALQAG VVWVNCYMIL SAQCPFGGFK MSGNGRELGE 
HGLYEYTELK TVAMKISQKN S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Aldh1a1

Associated with

Other Information

Cloning of a cDNA encoding rat aldehyde dehydrogenase with high activity for retinal oxidation. PubMed ID: 8543180

A preliminary report on the cloning of a constitutively expressed rat liver cytosolic ALDH cDNA by PCR. PubMed ID: 9059608

Cloning of a cDNA encoding a constitutively expressed rat liver cytosolic aldehyde dehydrogenase. PubMed ID: 9240474

Cloning of a rat cDNA encoding retinal dehydrogenase isozyme type I and its expression in E. coli. PubMed ID: 9218716

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid. PubMed ID: 7832787

Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress. PubMed ID: 15623782

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903