Details for: ALOX12B

Gene ID: 242

Symbol: ALOX12B

Ensembl ID: ENSG00000179477

Description: arachidonate 12-lipoxygenase, 12R type

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 12.0865
    Cell Significance Index: -1.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.6235
    Cell Significance Index: -1.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 1.4454
    Cell Significance Index: -1.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3684
    Cell Significance Index: 260.4200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.2633
    Cell Significance Index: 2.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9417
    Cell Significance Index: 93.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8663
    Cell Significance Index: 782.2500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6450
    Cell Significance Index: 5.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5327
    Cell Significance Index: 11.3500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5324
    Cell Significance Index: 7.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5100
    Cell Significance Index: 16.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4658
    Cell Significance Index: 75.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4602
    Cell Significance Index: 50.0600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.4362
    Cell Significance Index: 4.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3596
    Cell Significance Index: 7.8800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.3185
    Cell Significance Index: 4.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2792
    Cell Significance Index: 19.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2285
    Cell Significance Index: 13.7200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2127
    Cell Significance Index: 5.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2126
    Cell Significance Index: 42.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1924
    Cell Significance Index: 2.7600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.0962
    Cell Significance Index: 3.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0848
    Cell Significance Index: 2.9800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0538
    Cell Significance Index: 0.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0445
    Cell Significance Index: 8.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0342
    Cell Significance Index: 1.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0325
    Cell Significance Index: 0.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0321
    Cell Significance Index: 1.6700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0314
    Cell Significance Index: 0.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0302
    Cell Significance Index: 10.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0296
    Cell Significance Index: 5.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0242
    Cell Significance Index: 0.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0217
    Cell Significance Index: 0.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0185
    Cell Significance Index: 0.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0148
    Cell Significance Index: 0.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0121
    Cell Significance Index: 0.5500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0117
    Cell Significance Index: 0.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0073
    Cell Significance Index: 0.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0049
    Cell Significance Index: 0.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0033
    Cell Significance Index: 0.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0019
    Cell Significance Index: 0.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0009
    Cell Significance Index: 0.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0010
    Cell Significance Index: -1.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0019
    Cell Significance Index: -1.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0021
    Cell Significance Index: -0.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0022
    Cell Significance Index: -1.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0023
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0024
    Cell Significance Index: -1.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0027
    Cell Significance Index: -1.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0029
    Cell Significance Index: -1.6600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.0035
    Cell Significance Index: -0.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0037
    Cell Significance Index: -1.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0056
    Cell Significance Index: -0.1400
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0063
    Cell Significance Index: -0.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0063
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0070
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0086
    Cell Significance Index: -1.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0095
    Cell Significance Index: -1.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0097
    Cell Significance Index: -0.6500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0100
    Cell Significance Index: -0.1500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0107
    Cell Significance Index: -0.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0108
    Cell Significance Index: -1.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0130
    Cell Significance Index: -1.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0131
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0157
    Cell Significance Index: -1.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0170
    Cell Significance Index: -1.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0171
    Cell Significance Index: -0.4800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0173
    Cell Significance Index: -0.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0178
    Cell Significance Index: -1.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0203
    Cell Significance Index: -1.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0210
    Cell Significance Index: -0.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0224
    Cell Significance Index: -1.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0255
    Cell Significance Index: -1.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0267
    Cell Significance Index: -1.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0284
    Cell Significance Index: -0.7600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0284
    Cell Significance Index: -0.7100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0286
    Cell Significance Index: -0.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0299
    Cell Significance Index: -1.4100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0300
    Cell Significance Index: -0.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0302
    Cell Significance Index: -0.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0308
    Cell Significance Index: -1.0100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0309
    Cell Significance Index: -0.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0310
    Cell Significance Index: -2.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0321
    Cell Significance Index: -1.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0358
    Cell Significance Index: -0.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0361
    Cell Significance Index: -1.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0365
    Cell Significance Index: -1.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0442
    Cell Significance Index: -1.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0443
    Cell Significance Index: -1.5400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0454
    Cell Significance Index: -0.6500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0464
    Cell Significance Index: -0.4400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0475
    Cell Significance Index: -1.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0478
    Cell Significance Index: -0.9600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0478
    Cell Significance Index: -0.8200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0491
    Cell Significance Index: -0.9700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0499
    Cell Significance Index: -1.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The ALOX12B gene is a single-copy gene located on human chromosome 1q42.3. It encodes a 383-amino acid protein, LX12B_HUMAN, which shares a high degree of sequence homology with other arachidonate 12-lipoxygenases. The LX12B_HUMAN protein is primarily expressed in cells of the immune system, including endothelial cells, goblet cells, granulocytes, and epithelial cells of the small intestine. Notably, ALOX12B is also expressed in pericytes, a type of endothelial cell that plays a critical role in maintaining the integrity of blood vessels. **Pathways and Functions:** The ALOX12B gene is involved in several key pathways, including: 1. **Arachidonate 8(r)-lipoxygenase activity:** ALOX12B catalyzes the conversion of arachidonic acid into 12-eicosatetraenoic acid, which is a precursor for the production of various lipid mediators, including leukotrienes and lipoxins. 2. **Arachidonate 12(r)-lipoxygenase activity:** ALOX12B also catalyzes the conversion of arachidonic acid into 12,14-dihydroperoxyeicosatetraenoic acid, which is a precursor for the production of leukotrienes. 3. **Hepoxilin biosynthetic process:** ALOX12B is involved in the production of heparan sulfate-binding protein (HSP), also known as heparan sulfate-heparan sulfate proteoglycan (HSP/HSPG), which is a precursor for the production of hepoxilins. 4. **Lipid metabolism:** ALOX12B is involved in the regulation of lipid metabolism, including the synthesis of sphingolipids and the breakdown of fatty acids. **Clinical Significance:** The ALOX12B gene has been implicated in various immune-related disorders and diseases, including: 1. **Asthma:** ALOX12B has been shown to play a critical role in the regulation of airway inflammation and hyperresponsiveness in asthma. 2. **Allergic rhinitis:** ALOX12B has been implicated in the pathogenesis of allergic rhinitis, a condition characterized by inflammation and hyperresponsiveness of the nasal mucosa. 3. **Irritable bowel syndrome (IBS):** ALOX12B has been shown to play a role in the regulation of gut motility and inflammation in IBS. 4. **Cancer:** ALOX12B has been implicated in the progression of various cancers, including colorectal cancer, where it is involved in the regulation of cell proliferation and apoptosis. In conclusion, the ALOX12B gene is a critical regulator of immune responses and lipid metabolism, and its dysregulation has been implicated in various immune-related disorders and diseases. Further research is needed to fully elucidate the role of ALOX12B in human health and disease.

Genular Protein ID: 637747891

Symbol: LX12B_HUMAN

Name: Epidermis-type lipoxygenase 12

UniProtKB Accession Codes:

O75342

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 54 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PRIDE 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 32 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9618483

Title: A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression.

PubMed ID: 9618483

DOI: 10.1073/pnas.95.12.6744

PubMed ID: 9837935

Title: Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment.

PubMed ID: 9837935

DOI: 10.1074/jbc.273.50.33540

PubMed ID: 11350124

Title: A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression.

PubMed ID: 11350124

DOI: 10.1006/geno.2001.6519

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21558561

Title: Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope.

PubMed ID: 21558561

DOI: 10.1074/jbc.m111.251496

PubMed ID: 22441738

Title: A role for 12R-lipoxygenase in MUC5AC expression by respiratory epithelial cells.

PubMed ID: 22441738

DOI: 10.1183/09031936.00023111

PubMed ID: 11773004

Title: Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.

PubMed ID: 11773004

DOI: 10.1093/hmg/11.1.107

PubMed ID: 15629692

Title: Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.

PubMed ID: 15629692

DOI: 10.1016/j.bbalip.2004.10.007

PubMed ID: 16116617

Title: Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis.

PubMed ID: 16116617

DOI: 10.1002/humu.20236

PubMed ID: 19131948

Title: Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B.

PubMed ID: 19131948

DOI: 10.1038/jid.2008.409

PubMed ID: 19890349

Title: Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients.

PubMed ID: 19890349

DOI: 10.1038/jid.2009.346

Sequence Information:

  • Length: 701
  • Mass: 80356
  • Checksum: C334075759F8B077
  • Sequence:
    • MATYKVRVAT GTDLLSGTRD SISLTIVGTQ GESHKQLLNH FGRDFATGAV GQYTVQCPQD 
LGELIIIRLH KERYAFFPKD PWYCNYVQIC APNGRIYHFP AYQWMDGYET LALREATGKT 
TADDSLPVLL EHRKEEIRAK QDFYHWRVFL PGLPSYVHIP SYRPPVRRHR NPNRPEWNGY 
IPGFPILINF KATKFLNLNL RYSFLKTASF FVRLGPMALA FKVRGLLDCK HSWKRLKDIR 
KIFPGKKSVV SEYVAEHWAE DTFFGYQYLN GVNPGLIRRC TRIPDKFPVT DDMVAPFLGE 
GTCLQAELEK GNIYLADYRI MEGIPTVELS GRKQHHCAPL CLLHFGPEGK MMPIAIQLSQ 
TPGPDCPIFL PSDSEWDWLL AKTWVRYAEF YSHEAIAHLL ETHLIAEAFC LALLRNLPMC 
HPLYKLLIPH TRYTVQINSI GRAVLLNEGG LSAKGMSLGV EGFAGVMVRA LSELTYDSLY 
LPNDFVERGV QDLPGYYYRD DSLAVWNALE KYVTEIITYY YPSDAAVEGD PELQSWVQEI 
FKECLLGRES SGFPRCLRTV PELIRYVTIV IYTCSAKHAA VNTGQMEFTA WMPNFPASMR 
NPPIQTKGLT TLETFMDTLP DVKTTCITLL VLWTLSREPD DRRPLGHFPD IHFVEEAPRR 
SIEAFRQRLN QISHDIRQRN KCLPIPYYYL DPVLIENSIS I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.