Details for: ALOX12B

Gene ID: 242

Symbol: ALOX12B

Ensembl ID: ENSG00000179477

Description: arachidonate 12-lipoxygenase, 12R type

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.16
    Marker Score: 2178
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.36
    Marker Score: 796
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.24
    Marker Score: 2566
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4820
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.05
    Marker Score: 2130
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5335
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.85
    Marker Score: 1617
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 635
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 386
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 468
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.57
    Marker Score: 8971
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.51
    Marker Score: 423
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 477
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.39
    Marker Score: 151
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 208
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 210
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.34
    Marker Score: 2917
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.34
    Marker Score: 177
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.34
    Marker Score: 790
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.33
    Marker Score: 105
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.31
    Marker Score: 99
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 140
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.28
    Marker Score: 2931
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.28
    Marker Score: 217
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.26
    Marker Score: 70
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.25
    Marker Score: 283
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.24
    Marker Score: 85.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2
    Marker Score: 90
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.2
    Marker Score: 87
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.19
    Marker Score: 1293
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.19
    Marker Score: 288
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.18
    Marker Score: 104
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.17
    Marker Score: 73
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.17
    Marker Score: 52
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.16
    Marker Score: 87
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.13
    Marker Score: 521
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.12
    Marker Score: 80.5
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.12
    Marker Score: 166
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.11
    Marker Score: 978
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.11
    Marker Score: 64
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.11
    Marker Score: 6601
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.11
    Marker Score: 101
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.11
    Marker Score: 171
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.1
    Marker Score: 260
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1
    Marker Score: 123
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1
    Marker Score: 87
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.1
    Marker Score: 163
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1
    Marker Score: 95
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.09
    Marker Score: 66.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.07
    Marker Score: 627
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.07
    Marker Score: 89
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 62
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.07
    Marker Score: 139
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.07
    Marker Score: 16.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.07
    Marker Score: 257
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.07
    Marker Score: 16.5
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.07
    Marker Score: 43
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.06
    Marker Score: 77
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 17.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.06
    Marker Score: 91
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.06
    Marker Score: 17.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.06
    Marker Score: 448
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.06
    Marker Score: 14.5
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.06
    Marker Score: 16

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Other Information

**Key characteristics:** * The protein is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a member of the ALOX family of enzymes, which are involved in the metabolism of arachidonic acid and its derivatives. * The protein is expressed in high levels in blood vessel endothelial cells, suggesting that it is involved in the regulation of blood flow. * It is also expressed in high levels in colon goblet cells, suggesting that it may be involved in the metabolism of dietary arachidonic acid. **Pathways and functions:** * The protein is involved in the arachidonate 8(r)-lipoxygenase activity, which is responsible for the oxidation of arachidonic acid to 12-eicosatetraenoic acid. * It is also involved in the arachidonate 12(r)-lipoxygenase activity, which is responsible for the oxidation of arachidonic acid to 12-hydroxyeicosatetraenoic acid. * It is also involved in the arachidonate 12(s)-lipoxygenase activity, which is responsible for the oxidation of arachidonic acid to 12-hydroxy-12-oxo-tetradecatonic acid. * It is involved in the fatty acid metabolism, as it is a key enzyme in the synthesis of 12-eicosatetraenoic acid from arachidonic acid. * It is also involved in the metabolism of lipids, as it is a key enzyme in the synthesis of 12-eicosatetraenoic acid from linoleic acid. **Clinical significance:** Mutations in the ALOX12B gene have been linked to several human diseases, including atherosclerosis, hypertension, and metabolic syndrome. These diseases are characterized by the accumulation of oxidized lipids in the blood, which can contribute to inflammation and disease progression. Therefore, ALOX12B is a promising target for the development of new therapies for these diseases.

Genular Protein ID: 637747891

Symbol: LX12B_HUMAN

Name: Epidermis-type lipoxygenase 12

UniProtKB Accession Codes:

O75342

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 54 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PRIDE 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 32 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9618483

Title: A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression.

PubMed ID: 9618483

DOI: 10.1073/pnas.95.12.6744

PubMed ID: 9837935

Title: Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment.

PubMed ID: 9837935

DOI: 10.1074/jbc.273.50.33540

PubMed ID: 11350124

Title: A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression.

PubMed ID: 11350124

DOI: 10.1006/geno.2001.6519

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21558561

Title: Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope.

PubMed ID: 21558561

DOI: 10.1074/jbc.m111.251496

PubMed ID: 22441738

Title: A role for 12R-lipoxygenase in MUC5AC expression by respiratory epithelial cells.

PubMed ID: 22441738

DOI: 10.1183/09031936.00023111

PubMed ID: 11773004

Title: Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.

PubMed ID: 11773004

DOI: 10.1093/hmg/11.1.107

PubMed ID: 15629692

Title: Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.

PubMed ID: 15629692

DOI: 10.1016/j.bbalip.2004.10.007

PubMed ID: 16116617

Title: Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis.

PubMed ID: 16116617

DOI: 10.1002/humu.20236

PubMed ID: 19131948

Title: Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B.

PubMed ID: 19131948

DOI: 10.1038/jid.2008.409

PubMed ID: 19890349

Title: Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients.

PubMed ID: 19890349

DOI: 10.1038/jid.2009.346

Sequence Information:

  • Length: 701
  • Mass: 80356
  • Checksum: C334075759F8B077
  • Sequence:
    • MATYKVRVAT GTDLLSGTRD SISLTIVGTQ GESHKQLLNH FGRDFATGAV GQYTVQCPQD 
LGELIIIRLH KERYAFFPKD PWYCNYVQIC APNGRIYHFP AYQWMDGYET LALREATGKT 
TADDSLPVLL EHRKEEIRAK QDFYHWRVFL PGLPSYVHIP SYRPPVRRHR NPNRPEWNGY 
IPGFPILINF KATKFLNLNL RYSFLKTASF FVRLGPMALA FKVRGLLDCK HSWKRLKDIR 
KIFPGKKSVV SEYVAEHWAE DTFFGYQYLN GVNPGLIRRC TRIPDKFPVT DDMVAPFLGE 
GTCLQAELEK GNIYLADYRI MEGIPTVELS GRKQHHCAPL CLLHFGPEGK MMPIAIQLSQ 
TPGPDCPIFL PSDSEWDWLL AKTWVRYAEF YSHEAIAHLL ETHLIAEAFC LALLRNLPMC 
HPLYKLLIPH TRYTVQINSI GRAVLLNEGG LSAKGMSLGV EGFAGVMVRA LSELTYDSLY 
LPNDFVERGV QDLPGYYYRD DSLAVWNALE KYVTEIITYY YPSDAAVEGD PELQSWVQEI 
FKECLLGRES SGFPRCLRTV PELIRYVTIV IYTCSAKHAA VNTGQMEFTA WMPNFPASMR 
NPPIQTKGLT TLETFMDTLP DVKTTCITLL VLWTLSREPD DRRPLGHFPD IHFVEEAPRR 
SIEAFRQRLN QISHDIRQRN KCLPIPYYYL DPVLIENSIS I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.