Genular: Defining Cellular Identity and Function

Details for: Ar

Gene ID: 24208

Symbol: Ar

Ensembl ID: ENSRNOG00000005639

Description: androgen receptor

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-RNO-5625886)
Cellular responses to stimuli
(R-RNO-8953897)
Cellular responses to stress
(R-RNO-2262752)
Deubiquitination
(R-RNO-5688426)
Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-RNO-3371497)
Metabolism of proteins
(R-RNO-392499)
Nuclear receptor transcription pathway
(R-RNO-383280)
Post-translational protein modification
(R-RNO-597592)
Rho gtpase effectors
(R-RNO-195258)
Rho gtpases activate pkns
(R-RNO-5625740)
Rna polymerase ii transcription
(R-RNO-73857)
Signaling by rho gtpases
(R-RNO-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-RNO-9716542)
Signal transduction
(R-RNO-162582)
Sumo e3 ligases sumoylate target proteins
(R-RNO-3108232)
Sumoylation
(R-RNO-2990846)
Sumoylation of intracellular receptors
(R-RNO-4090294)
Ub-specific processing proteases
(R-RNO-5689880)
Androgen binding
(GO:0005497)
Androgen receptor signaling pathway
(GO:0030521)
Animal organ formation
(GO:0048645)
Atpase binding
(GO:0051117)
Beta-catenin binding
(GO:0008013)
Chromatin binding
(GO:0003682)
Copulation
(GO:0007620)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna binding
(GO:0003677)
Enzyme binding
(GO:0019899)
Epithelial cell morphogenesis
(GO:0003382)
Estrogen response element binding
(GO:0034056)
Fertilization
(GO:0009566)
Insulin-like growth factor receptor signaling pathway
(GO:0048009)
Intracellular estrogen receptor signaling pathway
(GO:0030520)
Intracellular receptor signaling pathway
(GO:0030522)
Intracellular steroid hormone receptor signaling pathway
(GO:0030518)
In utero embryonic development
(GO:0001701)
Leydig cell differentiation
(GO:0033327)
Male courtship behavior
(GO:0008049)
Male genitalia morphogenesis
(GO:0048808)
Male gonad development
(GO:0008584)
Male sex differentiation
(GO:0046661)
Male somatic sex determination
(GO:0019102)
Mapk cascade
(GO:0000165)
Molecular adaptor activity
(GO:0060090)
Multicellular organism growth
(GO:0035264)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of integrin biosynthetic process
(GO:0045720)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear androgen receptor binding
(GO:0050681)
Nuclear receptor activity
(GO:0004879)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of insulin-like growth factor receptor signaling pathway
(GO:0043568)
Positive regulation of integrin biosynthetic process
(GO:0045726)
Positive regulation of intracellular estrogen receptor signaling pathway
(GO:0033148)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription by rna polymerase iii
(GO:0045945)
Pou domain binding
(GO:0070974)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of developmental growth
(GO:0048638)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of systemic arterial blood pressure
(GO:0003073)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Reproductive behavior
(GO:0019098)
Reproductive structure development
(GO:0048608)
Response to estradiol
(GO:0032355)
Response to insulin
(GO:0032868)
Response to testosterone
(GO:0033574)
Ribonucleotide binding
(GO:0032553)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii general transcription initiation factor binding
(GO:0001091)
Sequence-specific dna binding
(GO:0043565)
Signaling receptor binding
(GO:0005102)
Single fertilization
(GO:0007338)
Skeletal muscle hypertrophy
(GO:0014734)
Spermatogenesis
(GO:0007283)
Steroid binding
(GO:0005496)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Androgen receptor

Genular Protein ID: 2829995346

Symbol: ANDR_RAT

Name: Androgen receptor

UniProtKB Accession Codes:

P15207 Q63049

Database IDs:

Citations:

PubMed ID: 3216867

Title: The rat androgen receptor: primary structure, autoregulation of its messenger ribonucleic acid, and immunocytochemical localization of the receptor protein.

PubMed ID: 3216867

DOI: 10.1210/mend-2-12-1276

PubMed ID: 3174628

Title: Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors.

PubMed ID: 3174628

DOI: 10.1073/pnas.85.19.7211

PubMed ID: 2341409

Title: A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat.

PubMed ID: 2341409

DOI: 10.1016/s0021-9258(19)38972-0

PubMed ID: 9725910

Title: Activation of androgen receptor function by a novel nuclear protein kinase.

PubMed ID: 9725910

DOI: 10.1091/mbc.9.9.2527

PubMed ID: 12350225

Title: A novel steroid receptor co-activator protein (SRAP) as an alternative form of steroid receptor RNA-activator gene: expression in prostate cancer cells and enhancement of androgen receptor activity.

PubMed ID: 12350225

DOI: 10.1042/bj20020743

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 11320241

Title: Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone.

PubMed ID: 11320241

DOI: 10.1073/pnas.081565498

PubMed ID: 15037741

Title: Structural basis of androgen receptor binding to selective androgen response elements.

PubMed ID: 15037741

DOI: 10.1073/pnas.0401123101

PubMed ID: 15603938

Title: Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists.

PubMed ID: 15603938

DOI: 10.1016/j.bmcl.2004.10.085

PubMed ID: 17181141

Title: Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold.

PubMed ID: 17181141

DOI: 10.1021/jm061101w

PubMed ID: 17008401

Title: Pharmacological and X-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats.

PubMed ID: 17008401

DOI: 10.1210/en.2006-0843

Sequence Information:

Length: 902
Mass: 98218
Checksum: 43F4064759FDCBED
Sequence:

MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REAIQNPGPR HPEAASIAPP GACLQQRQET 
SPRRRRRQQH PEDGSPQAHI RGTTGYLALE EEQQPSQQQS ASEGHPESGC LPEPGAATAP 
GKGLPQQPPA PPDQDDSAAP STLSLLGPTF PGLSSCSADI KDILSEAGTM QLLQQQQQQQ 
QQQQQQQQQQ QQQQQEVISE GSSSVRAREA TGAPSSSKDS YLGGNSTISD SAKELCKAVS 
VSMGLGVEAL EHLSPGEQLR GDCMYASLLG GPPAVRPTPC APLAECKGLS LDEGPGKGTE 
ETAEYSSFKG GYAKGLEGES LGCSGSSEAG SSGTLEIPSS LSLYKSGAVD EAAAYQNRDY 
YNFPLALSGP PHPPPPTHPH ARIKLENPSD YGSAWAAAAA QCRYGDLASL HGGSVAGPST 
GSPPATASSS WHTLFTAEEG QLYGPGGGGG SSSPSDAGPV APYGYTRPPQ GLASQEGDFS 
ASEVWYPGGV VNRVPYPSPS CVKSEMGPWM ENYSGPYGDM RLDSTRDHVL PIDYYFPPQK 
TCLICGDEAS GCHYGALTCG SCKVFFKRAA EGKQKYLCAS RNDCTIDKFR RKNCPSCRLR 
KCYEAGMTLG ARKLKKLGNL KLQEEGENSS AGSPTEDPSQ KMTVSHIEGY ECQPIFLNVL 
EAIEPGVVCA GHDNNQPDSF AALLSSLNEL GERQLVHVVK WAKALPGFRN LHVDDQMAVI 
QYSWMGLMVF AMGWRSFTNV NSRMLYFAPD LVFNEYRMHK SRMYSQCVRM RHLSQEFGWL 
QITPQEFLCM KALLLFSIIP VDGLKNQKFF DELRMNYIKE LDRIIACKRK NPTSCSRRFY 
QLTKLLDSVQ PIARELHQFT FDLLIKSHMV SVDFPEMMAE IISVQVPKIL SGKVKPIYFH 
TQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ar

Associated with

Other Information

The rat androgen receptor: primary structure, autoregulation of its messenger ribonucleic acid, and immunocytochemical localization of the receptor protein. PubMed ID: 3216867

Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors. PubMed ID: 3174628

A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat. PubMed ID: 2341409

Activation of androgen receptor function by a novel nuclear protein kinase. PubMed ID: 9725910

A novel steroid receptor co-activator protein (SRAP) as an alternative form of steroid receptor RNA-activator gene: expression in prostate cancer cells and enhancement of androgen receptor activity. PubMed ID: 12350225

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone. PubMed ID: 11320241

Structural basis of androgen receptor binding to selective androgen response elements. PubMed ID: 15037741

Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists. PubMed ID: 15603938

Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold. PubMed ID: 17181141

Pharmacological and X-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats. PubMed ID: 17008401