Details for: Ascl2

Gene ID: 24209

Symbol: Ascl2

Ensembl ID: ENSRNOG00000020434

Description: achaete-scute family bHLH transcription factor 2

Associated with

  • Bhlh transcription factor binding
    (GO:0043425)
  • Cell differentiation
    (GO:0030154)
  • Chorionic trophoblast cell development
    (GO:0060719)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • E-box binding
    (GO:0070888)
  • In utero embryonic development
    (GO:0001701)
  • Negative regulation of schwann cell proliferation
    (GO:0010626)
  • Negative regulation of t-helper 1 cell differentiation
    (GO:0045626)
  • Negative regulation of t-helper 2 cell differentiation
    (GO:0045629)
  • Negative regulation of t-helper 17 cell differentiation
    (GO:2000320)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron differentiation
    (GO:0030182)
  • Nucleus
    (GO:0005634)
  • Placenta development
    (GO:0001890)
  • Positive regulation of t cell migration
    (GO:2000406)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of neurogenesis
    (GO:0050767)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to hypoxia
    (GO:0001666)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sensory organ development
    (GO:0007423)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Spongiotrophoblast differentiation
    (GO:0060708)
  • Spongiotrophoblast layer development
    (GO:0060712)
  • Stem cell population maintenance
    (GO:0019827)
  • T follicular helper cell differentiation
    (GO:0061470)

Other Information

Genular Protein ID: 168184137

Symbol: ASCL2_RAT

Name: Achaete-scute homolog 2

UniProtKB Accession Codes:

P19360

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 EMBL 1 Ensembl 2 GO 35 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 eggNOG 1

Citations:

PubMed ID: 2392153

Title: Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors.

PubMed ID: 2392153

DOI: 10.1038/346858a0

PubMed ID: 1314394

Title: DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer.

PubMed ID: 1314394

DOI: 10.1073/pnas.89.8.3596

PubMed ID: 12196582

Title: Mammalian achaete scute homolog 2 is expressed in the adult sciatic nerve and regulates the expression of Krox24, Mob-1, CXCR4, and p57kip2 in Schwann cells.

PubMed ID: 12196582

DOI: 10.1523/jneurosci.22-17-07586.2002

Sequence Information:

  • Length: 260
  • Mass: 27695
  • Checksum: E10402DD1F7434C5
  • Sequence:
    • MESHFNWYGV PRLQKASDAC PRESCSSALP EAREGANVHF PPHPVPREHF SCGAPKPVAG 
APALNASLMD GGALPRLVPT SSGVAGACTA RRRPPSPELL RCSRRRRSGA TEASSSSAAV 
ARRNERERNR VKLVNLGFQA LRQHVPHGGA NKKLSKVETL RSAVEYIRAL QRLLAEHDAV 
RAALSGGLLT PATRPSDVCT QPSASPASAS LSCTSTSPDR LGCSEPASPR SAYSSEDSSC 
EGETYPMGQM FDFSNWLGGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.