Genular: Defining Cellular Identity and Function

Details for: Atp1a1

Gene ID: 24211

Symbol: Atp1a1

Ensembl ID: ENSRNOG00000030019

Description: ATPase Na+/K+ transporting subunit alpha 1

Associated with

Cardiac conduction
(R-RNO-5576891)
Ion channel transport
(R-RNO-983712)
Ion homeostasis
(R-RNO-5578775)
Ion transport by p-type atpases
(R-RNO-936837)
Muscle contraction
(R-RNO-397014)
Transport of small molecules
(R-RNO-382551)
Adp binding
(GO:0043531)
Ankyrin binding
(GO:0030506)
Apical plasma membrane
(GO:0016324)
Atpase binding
(GO:0051117)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Axon
(GO:0030424)
Basolateral plasma membrane
(GO:0016323)
Cardiac muscle contraction
(GO:0060048)
Caveola
(GO:0005901)
Cellular response to mechanical stimulus
(GO:0071260)
Cellular response to steroid hormone stimulus
(GO:0071383)
Endoplasmic reticulum
(GO:0005783)
Endosome
(GO:0005768)
Energy coupled proton transmembrane transport, against electrochemical gradient
(GO:0015988)
Establishment or maintenance of transmembrane electrochemical gradient
(GO:0010248)
Golgi apparatus
(GO:0005794)
Heart contraction
(GO:0060047)
Intercalated disc
(GO:0014704)
Intracellular potassium ion homeostasis
(GO:0030007)
Intracellular sodium ion homeostasis
(GO:0006883)
Lateral plasma membrane
(GO:0016328)
Melanosome
(GO:0042470)
Membrane
(GO:0016020)
Membrane hyperpolarization
(GO:0060081)
Membrane repolarization
(GO:0086009)
Metal ion binding
(GO:0046872)
Negative regulation of glucocorticoid biosynthetic process
(GO:0031947)
Negative regulation of heart contraction
(GO:0045822)
Organelle membrane
(GO:0031090)
Osmosensory signaling pathway
(GO:0007231)
P-type potassium transmembrane transporter activity
(GO:0008556)
P-type sodium:potassium-exchanging transporter activity
(GO:0005391)
Phosphatase activity
(GO:0016791)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Plasma membrane
(GO:0005886)
Positive regulation of heart contraction
(GO:0045823)
Positive regulation of striated muscle contraction
(GO:0045989)
Postsynaptic density
(GO:0014069)
Potassium ion binding
(GO:0030955)
Potassium ion import across plasma membrane
(GO:1990573)
Potassium ion transport
(GO:0006813)
Protein-containing complex
(GO:0032991)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein heterodimerization activity
(GO:0046982)
Protein kinase binding
(GO:0019901)
Proton transmembrane transport
(GO:1902600)
Regulation of blood pressure
(GO:0008217)
Regulation of cardiac muscle cell contraction
(GO:0086004)
Regulation of sodium ion transport
(GO:0002028)
Regulation of the force of heart contraction
(GO:0002026)
Relaxation of cardiac muscle
(GO:0055119)
Response to glycoside
(GO:1903416)
Response to xenobiotic stimulus
(GO:0009410)
Sarcolemma
(GO:0042383)
Sodium:potassium-exchanging atpase complex
(GO:0005890)
Sodium ion binding
(GO:0031402)
Sodium ion export across plasma membrane
(GO:0036376)
Sodium ion homeostasis
(GO:0055078)
Sodium ion transport
(GO:0006814)
Sperm flagellum
(GO:0036126)
Steroid hormone binding
(GO:1990239)
T-tubule
(GO:0030315)
Transmembrane transport
(GO:0055085)

Other Information

Proteins

Sodium/potassium-transporting ATPase subunit alpha-1

Genular Protein ID: 3437470825

Symbol: AT1A1_RAT

Name: Sodium/potassium-transporting ATPase subunit alpha-1

UniProtKB Accession Codes:

P06685 Q64609

Database IDs:

Citations:

PubMed ID: 3028470

Title: Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain.

PubMed ID: 3028470

DOI: 10.1021/bi00373a001

PubMed ID: 2822682

Title: Primary structures of two types of alpha-subunit of rat brain Na+,K+,-ATPase deduced from cDNA sequences.

PubMed ID: 2822682

DOI: 10.1093/oxfordjournals.jbchem.a122039

PubMed ID: 2822726

Title: Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications.

PubMed ID: 2822726

DOI: 10.1083/jcb.105.4.1855

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2994074

Title: Molecular cloning of rat brain Na,K-ATPase alpha-subunit cDNA.

PubMed ID: 2994074

DOI: 10.1073/pnas.82.18.6357

PubMed ID: 2166579

Title: Cloning and analysis of the 5'-flanking region of rat Na+/K(+)-ATPase alpha 1 subunit gene.

PubMed ID: 2166579

DOI: 10.1016/0167-4781(90)90099-n

PubMed ID: 7510709

Title: Identification of the phosphorylation site for cAMP-dependent protein kinase on Na+,K(+)-ATPase and effects of site-directed mutagenesis.

PubMed ID: 7510709

DOI: 10.1016/s0021-9258(17)37117-x

PubMed ID: 9435504

Title: Regulation of rat Na(+)-K(+)-ATPase activity by PKC is modulated by state of phosphorylation of Ser-943 by PKA.

PubMed ID: 9435504

DOI: 10.1152/ajpcell.1997.273.6.c1981

PubMed ID: 10473631

Title: Insulin-induced stimulation of Na+,K(+)-ATPase activity in kidney proximal tubule cells depends on phosphorylation of the alpha-subunit at Tyr-10.

PubMed ID: 10473631

DOI: 10.1091/mbc.10.9.2847

PubMed ID: 7775468

Title: Structural basis for species-specific differences in the phosphorylation of Na,K-ATPase by protein kinase C.

PubMed ID: 7775468

DOI: 10.1074/jbc.270.23.14072

PubMed ID: 10823893

Title: Phosphoinositide-3 kinase binds to a proline-rich motif in the Na+, K+-ATPase alpha subunit and regulates its trafficking.

PubMed ID: 10823893

DOI: 10.1073/pnas.100128297

PubMed ID: 15743908

Title: FXYD3 (Mat-8), a new regulator of Na,K-ATPase.

PubMed ID: 15743908

DOI: 10.1091/mbc.e04-10-0878

PubMed ID: 17283221

Title: The intracellular region of FXYD1 is sufficient to regulate cardiac Na/K ATPase.

PubMed ID: 17283221

DOI: 10.1096/fj.06-7269com

PubMed ID: 17939993

Title: SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process.

PubMed ID: 17939993

DOI: 10.1073/pnas.0706838104

PubMed ID: 19339511

Title: FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine 69 is a novel substrate for protein kinase C.

PubMed ID: 19339511

DOI: 10.1152/ajpcell.00523.2008

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 23532852

Title: A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle.

PubMed ID: 23532852

DOI: 10.1074/jbc.m113.460956

PubMed ID: 29499166

Title: Mutations in ATP1A1 Cause Dominant Charcot-Marie-Tooth Type 2.

PubMed ID: 29499166

DOI: 10.1016/j.ajhg.2018.01.023

PubMed ID: 30388404

Title: Germline de novo mutations in ATP1A1 cause renal hypomagnesemia, refractory seizures, and intellectual disability.

PubMed ID: 30388404

DOI: 10.1016/j.ajhg.2018.10.004

PubMed ID: 16914892

Title: An extracellular loop of the human non-gastric H,K-ATPase alpha-subunit is involved in apical plasma membrane polarization.

PubMed ID: 16914892

DOI: 10.1159/000095169

PubMed ID: 12730684

Title: ATP-induced conformational changes of the nucleotide-binding domain of Na,K-ATPase.

PubMed ID: 12730684

DOI: 10.1038/nsb924

Sequence Information:

Length: 1023
Mass: 113054
Checksum: 85E98233EE6C18E9
Sequence:

MGKGVGRDKY EPAAVSEHGD KKSKKAKKER DMDELKKEVS MDDHKLSLDE LHRKYGTDLS 
RGLTPARAAE ILARDGPNAL TPPPTTPEWV KFCRQLFGGF SMLLWIGAIL CFLAYGIRSA 
TEEEPPNDDL YLGVVLSAVV IITGCFSYYQ EAKSSKIMES FKNMVPQQAL VIRNGEKMSI 
NAEDVVVGDL VEVKGGDRIP ADLRIISANG CKVDNSSLTG ESEPQTRSPD FTNENPLETR 
NIAFFSTNCV EGTARGIVVY TGDRTVMGRI ATLASGLEGG QTPIAEEIEH FIHLITGVAV 
FLGVSFFILS LILEYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR MARKNCLVKN 
LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA DTTENQSGVS FDKTSATWFA 
LSRIAGLCNR AVFQANQENL PILKRAVAGD ASESALLKCI EVCCGSVMEM REKYTKIVEI 
PFNSTNKYQL SIHKNPNASE PKHLLVMKGA PERILDRCSS ILLHGKEQPL DEELKDAFQN 
AYLELGGLGE RVLGFCHLLL PDEQFPEGFQ FDTDEVNFPV DNLCFVGLIS MIDPPRAAVP 
DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI PVNQVNPRDA 
KACVVHGSDL KDMTSEELDD ILRYHTEIVF ARTSPQQKLI IVEGCQRQGA IVAVTGDGVN 
DSPALKKADI GVAMGIVGSD VSKQAADMIL LDDNFASIVT GVEEGRLIFD NLKKSIAYTL 
TSNIPEITPF LIFIIANIPL PLGTVTILCI DLGTDMVPAI SLAYEQAESD IMKRQPRNPK 
TDKLVNERLI SMAYGQIGMI QALGGFFTYF VILAENGFLP FHLLGIRETW DDRWINDVED 
SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR RNSVFQQGMK NKILIFGLFE 
ETALAAFLSY CPGMGAALRM YPLKPTWWFC AFPYSLLIFV YDEVRKLIIR RRPGGWVEKE 
TYY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Atp1a1

Associated with

Other Information

Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain. PubMed ID: 3028470

Primary structures of two types of alpha-subunit of rat brain Na+,K+,-ATPase deduced from cDNA sequences. PubMed ID: 2822682

Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications. PubMed ID: 2822726

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning of rat brain Na,K-ATPase alpha-subunit cDNA. PubMed ID: 2994074

Cloning and analysis of the 5'-flanking region of rat Na+/K(+)-ATPase alpha 1 subunit gene. PubMed ID: 2166579

Identification of the phosphorylation site for cAMP-dependent protein kinase on Na+,K(+)-ATPase and effects of site-directed mutagenesis. PubMed ID: 7510709

Regulation of rat Na(+)-K(+)-ATPase activity by PKC is modulated by state of phosphorylation of Ser-943 by PKA. PubMed ID: 9435504

Insulin-induced stimulation of Na+,K(+)-ATPase activity in kidney proximal tubule cells depends on phosphorylation of the alpha-subunit at Tyr-10. PubMed ID: 10473631

Structural basis for species-specific differences in the phosphorylation of Na,K-ATPase by protein kinase C. PubMed ID: 7775468

Phosphoinositide-3 kinase binds to a proline-rich motif in the Na+, K+-ATPase alpha subunit and regulates its trafficking. PubMed ID: 10823893

FXYD3 (Mat-8), a new regulator of Na,K-ATPase. PubMed ID: 15743908

The intracellular region of FXYD1 is sufficient to regulate cardiac Na/K ATPase. PubMed ID: 17283221

SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. PubMed ID: 17939993

FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine 69 is a novel substrate for protein kinase C. PubMed ID: 19339511

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle. PubMed ID: 23532852

Mutations in ATP1A1 Cause Dominant Charcot-Marie-Tooth Type 2. PubMed ID: 29499166

Germline de novo mutations in ATP1A1 cause renal hypomagnesemia, refractory seizures, and intellectual disability. PubMed ID: 30388404

An extracellular loop of the human non-gastric H,K-ATPase alpha-subunit is involved in apical plasma membrane polarization. PubMed ID: 16914892

ATP-induced conformational changes of the nucleotide-binding domain of Na,K-ATPase. PubMed ID: 12730684