Genular: Defining Cellular Identity and Function

Details for: B2m

Gene ID: 24223

Symbol: B2m

Ensembl ID: ENSRNOG00000017123

Description: beta-2 microglobulin

Associated with

Adaptive immune system
(R-RNO-1280218)
Antigen presentation: folding, assembly and peptide loading of class i mhc
(R-RNO-983170)
Antigen processing-cross presentation
(R-RNO-1236975)
Class i mhc mediated antigen processing & presentation
(R-RNO-983169)
Dap12 interactions
(R-RNO-2172127)
Dap12 signaling
(R-RNO-2424491)
Endosomal/vacuolar pathway
(R-RNO-1236977)
Er-phagosome pathway
(R-RNO-1236974)
Immune system
(R-RNO-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-RNO-198933)
Innate immune system
(R-RNO-168249)
Neutrophil degranulation
(R-RNO-6798695)
Amyloid fibril formation
(GO:1990000)
Antigen processing and presentation of endogenous peptide antigen via mhc class i
(GO:0019885)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Antigen processing and presentation of exogenous protein antigen via mhc class ib, tap-dependent
(GO:0002481)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Cellular response to iron(iii) ion
(GO:0071283)
Cellular response to iron ion
(GO:0071281)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to nicotine
(GO:0071316)
Cytosol
(GO:0005829)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Hfe-transferrin receptor complex
(GO:1990712)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Innate immune response
(GO:0045087)
Intracellular iron ion homeostasis
(GO:0006879)
Iron ion transport
(GO:0006826)
Late endosome membrane
(GO:0031902)
Learning or memory
(GO:0007611)
Lysosomal membrane
(GO:0005765)
Mhc class ii protein complex
(GO:0042613)
Mhc class ii protein complex binding
(GO:0023026)
Mhc class i peptide loading complex
(GO:0042824)
Mhc class i protein complex
(GO:0042612)
Multicellular organismal-level iron ion homeostasis
(GO:0060586)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of forebrain neuron differentiation
(GO:2000978)
Negative regulation of neurogenesis
(GO:0050768)
Negative regulation of neuron projection development
(GO:0010977)
Peptide antigen assembly with mhc class ii protein complex
(GO:0002503)
Peptide antigen assembly with mhc class i protein complex
(GO:0002502)
Peptide antigen binding
(GO:0042605)
Plasma membrane
(GO:0005886)
Positive regulation of cellular senescence
(GO:2000774)
Positive regulation of immune response
(GO:0050778)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Positive regulation of t cell activation
(GO:0050870)
Positive regulation of t cell cytokine production
(GO:0002726)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Protein homodimerization activity
(GO:0042803)
Protein homotetramerization
(GO:0051289)
Protein refolding
(GO:0042026)
Regulation of erythrocyte differentiation
(GO:0045646)
Regulation of iron ion transport
(GO:0034756)
Regulation of membrane depolarization
(GO:0003254)
Response to cadmium ion
(GO:0046686)
Response to molecule of bacterial origin
(GO:0002237)
Response to xenobiotic stimulus
(GO:0009410)
Sensory perception of smell
(GO:0007608)
Structural molecule activity
(GO:0005198)
T cell differentiation in thymus
(GO:0033077)
T cell mediated cytotoxicity
(GO:0001913)

Other Information

Proteins

Beta-2-microglobulin

Genular Protein ID: 3553602538

Symbol: B2MG_RAT

Name: Beta-2-microglobulin

UniProtKB Accession Codes:

P07151

Database IDs:

Citations:

PubMed ID: 3309895

Title: Nucleotide sequence of rat beta 2-microglobulin cDNA.

PubMed ID: 3309895

DOI: 10.1093/nar/15.18.7638

PubMed ID: 2911353

Title: An Fc receptor structurally related to MHC class I antigens.

PubMed ID: 2911353

DOI: 10.1038/337184a0

PubMed ID: 2689174

Title: The cDNA structure and expression analysis of the genes for the cysteine proteinase inhibitor cystatin C and for beta 2-microglobulin in rat brain.

PubMed ID: 2689174

DOI: 10.1111/j.1432-1033.1989.tb15174.x

PubMed ID: 7969498

Title: Crystal structure of the complex of rat neonatal Fc receptor with Fc.

PubMed ID: 7969498

DOI: 10.1038/372379a0

PubMed ID: 9493268

Title: Structural basis of pH-dependent antibody binding by the neonatal Fc receptor.

PubMed ID: 9493268

DOI: 10.1016/s0969-2126(98)00008-2

PubMed ID: 11163232

Title: Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-A(a).

PubMed ID: 11163232

DOI: 10.1016/s1074-7613(01)00091-7

Sequence Information:

Length: 119
Mass: 13720
Checksum: 3BE0A869E236DDFB
Sequence:

MARSVTVIFL VLVSLAVVLA IQKTPQIQVY SRHPPENGKP NFLNCYVSQF HPPQIEIELL 
KNGKKIPNIE MSDLSFSKDW SFYILAHTEF TPTETDVYAC RVKHVTLKEP KTVTWDRDM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: B2m

Associated with

Other Information

Nucleotide sequence of rat beta 2-microglobulin cDNA. PubMed ID: 3309895

An Fc receptor structurally related to MHC class I antigens. PubMed ID: 2911353

The cDNA structure and expression analysis of the genes for the cysteine proteinase inhibitor cystatin C and for beta 2-microglobulin in rat brain. PubMed ID: 2689174

Crystal structure of the complex of rat neonatal Fc receptor with Fc. PubMed ID: 7969498

Structural basis of pH-dependent antibody binding by the neonatal Fc receptor. PubMed ID: 9493268