Genular: Defining Cellular Identity and Function

Details for: Bcl2

Gene ID: 24224

Symbol: Bcl2

Description: BCL2, apoptosis regulator

Associated with

Actin filament organization
(GO:0007015)
Animal organ morphogenesis
(GO:0009887)
Apoptotic mitochondrial changes
(GO:0008637)
Apoptotic process
(GO:0006915)
Axonogenesis
(GO:0007409)
Axon regeneration
(GO:0031103)
B cell apoptotic process
(GO:0001783)
B cell differentiation
(GO:0030183)
B cell homeostasis
(GO:0001782)
B cell lineage commitment
(GO:0002326)
Behavioral fear response
(GO:0001662)
Bh3 domain binding
(GO:0051434)
Bh domain binding
(GO:0051400)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cell migration
(GO:0016477)
Cell morphogenesis
(GO:0000902)
Cell population proliferation
(GO:0008283)
Cerebral cortex development
(GO:0021987)
Channel activity
(GO:0015267)
Channel inhibitor activity
(GO:0016248)
Cochlear nucleus development
(GO:0021747)
Dna-binding transcription factor binding
(GO:0140297)
Dna damage response
(GO:0006974)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
G1/s transition of mitotic cell cycle
(GO:0000082)
Gland morphogenesis
(GO:0022612)
Hair follicle morphogenesis
(GO:0031069)
Hemopoiesis
(GO:0030097)
Identical protein binding
(GO:0042802)
Immune system development
(GO:0002520)
Intracellular calcium ion homeostasis
(GO:0006874)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0008631)
Kidney development
(GO:0001822)
Leukocyte homeostasis
(GO:0001776)
Lymphocyte homeostasis
(GO:0002260)
Lymphoid progenitor cell differentiation
(GO:0002320)
Male gonad development
(GO:0008584)
Melanin metabolic process
(GO:0006582)
Melanocyte differentiation
(GO:0030318)
Mesenchymal cell development
(GO:0014031)
Metanephros development
(GO:0001656)
Mitotic cell cycle
(GO:0000278)
Molecular adaptor activity
(GO:0060090)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of b cell apoptotic process
(GO:0002903)
Negative regulation of calcium ion transport into cytosol
(GO:0010523)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of ossification
(GO:0030279)
Ossification
(GO:0001503)
Ovarian follicle development
(GO:0001541)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of neuron maturation
(GO:0014042)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Post-embryonic development
(GO:0009791)
Protease binding
(GO:0002020)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein phosphatase 2a binding
(GO:0051721)
Protein phosphatase binding
(GO:0019903)
Protein polyubiquitination
(GO:0000209)
Regulation of autophagy
(GO:0010506)
Regulation of cell-matrix adhesion
(GO:0001952)
Regulation of gene expression
(GO:0010468)
Regulation of glycoprotein biosynthetic process
(GO:0010559)
Regulation of nitrogen utilization
(GO:0006808)
Regulation of protein stability
(GO:0031647)
Release of cytochrome c from mitochondria
(GO:0001836)
Renal system process
(GO:0003014)
Response to aluminum ion
(GO:0010044)
Response to caffeine
(GO:0031000)
Response to gamma radiation
(GO:0010332)
Response to hypoxia
(GO:0001666)
Response to inorganic substance
(GO:0010035)
Response to iron ion
(GO:0010039)
Response to ischemia
(GO:0002931)
Response to nutrient
(GO:0007584)
Response to organic cyclic compound
(GO:0014070)
Response to organic substance
(GO:0010033)
Response to oxidative stress
(GO:0006979)
Response to toxic substance
(GO:0009636)
Response to uv-b
(GO:0010224)
Response to xenobiotic stimulus
(GO:0009410)
Sequence-specific dna binding
(GO:0043565)
Smooth muscle cell migration
(GO:0014909)
T cell differentiation
(GO:0030217)
T cell lineage commitment
(GO:0002360)
Ubiquitin protein ligase binding
(GO:0031625)
Ureteric bud development
(GO:0001657)

Other Information

Proteins

Apoptosis regulator Bcl-2

Genular Protein ID: 4108282911

Symbol: BCL2_RAT

Name: Apoptosis regulator Bcl-2

UniProtKB Accession Codes:

P49950 Q62837 Q64032

Database IDs:

Citations:

PubMed ID: 8144041

Title: Cloning and sequencing of a cDNA encoding the rat Bcl-2 protein.

PubMed ID: 8144041

DOI: 10.1016/0378-1119(94)90561-4

PubMed ID: 7828536

Title: Expression of members of the Bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased Bax and constitutive Bcl-2 and Bcl-xlong messenger ribonucleic acid levels.

PubMed ID: 7828536

DOI: 10.1210/endo.136.1.7828536

PubMed ID: 7969891

Title: bcl-2 messenger RNA is localized in neurons of the developing and adult rat brain.

PubMed ID: 7969891

DOI: 10.1016/0306-4522(94)90069-8

PubMed ID: 19228691

Title: Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect.

PubMed ID: 19228691

DOI: 10.1074/jbc.m808750200

Sequence Information:

Length: 236
Mass: 26622
Checksum: E7688CB9071A872A
Sequence:

MAQAGRTGYD NREIVMKYIH YKLSQRGYEW DTGDEDSAPL RAAPTPGIFS FQPESNRTPA 
VHRDTAARTS PLRPLVANAG PALSPVPPVV HLTLRRAGDD FSRRYRRDFA EMSSQLHLTP 
FTARGRFATV VEELFRDGVN WGRIVAFFEF GGVMCVESVN REMSPLVDNI ALWMTEYLNR 
HLHTWIQDNG GWDAFVELYG PSMRPLFDFS WLSLKTLLSL ALVGACITLG AYLGHK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bcl2

Associated with

Other Information

Cloning and sequencing of a cDNA encoding the rat Bcl-2 protein. PubMed ID: 8144041

Expression of members of the Bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased Bax and constitutive Bcl-2 and Bcl-xlong messenger ribonucleic acid levels. PubMed ID: 7828536

bcl-2 messenger RNA is localized in neurons of the developing and adult rat brain. PubMed ID: 7969891

Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. PubMed ID: 19228691

Database document:

PubMed ID: 8144041

PubMed ID: 7828536

PubMed ID: 7969891

PubMed ID: 19228691