Genular: Defining Cellular Identity and Function

Details for: Bdnf

Gene ID: 24225

Symbol: Bdnf

Ensembl ID: ENSRNOG00000047466

Description: brain-derived neurotrophic factor

Associated with

Activated ntrk2 signals through frs2 and frs3
(R-RNO-9028731)
Activated ntrk2 signals through fyn
(R-RNO-9032500)
Activated ntrk2 signals through plcg1
(R-RNO-9026527)
Ntrk2 activates rac1
(R-RNO-9032759)
Signaling by ntrk2 (trkb)
(R-RNO-9006115)
Signaling by ntrks
(R-RNO-166520)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Axon extension
(GO:0048675)
Axon guidance
(GO:0007411)
Axon target recognition
(GO:0007412)
Behavioral fear response
(GO:0001662)
Behavioral response to cocaine
(GO:0048148)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cellular response to norepinephrine stimulus
(GO:0071874)
Cellular response to potassium ion
(GO:0035865)
Cellular response to tumor necrosis factor
(GO:0071356)
Chronic inflammatory response
(GO:0002544)
Circadian rhythm
(GO:0007623)
Cognition
(GO:0050890)
Collateral sprouting
(GO:0048668)
Dendrite development
(GO:0016358)
Dendrite extension
(GO:0097484)
Excitatory postsynaptic potential
(GO:0060079)
Fear response
(GO:0042596)
Feeding behavior
(GO:0007631)
Gamma-aminobutyric acid signaling pathway
(GO:0007214)
Glutamate secretion
(GO:0014047)
Growth factor activity
(GO:0008083)
Inhibitory postsynaptic potential
(GO:0060080)
Inner ear development
(GO:0048839)
Learning
(GO:0007612)
Learning or memory
(GO:0007611)
Mechanoreceptor differentiation
(GO:0042490)
Memory
(GO:0007613)
Mitochondrial electron transport, nadh to ubiquinone
(GO:0006120)
Modulation of chemical synaptic transmission
(GO:0050804)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of myotube differentiation
(GO:0010832)
Negative regulation of neuroblast proliferation
(GO:0007406)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of programmed cell death
(GO:0043069)
Negative regulation of striated muscle tissue development
(GO:0045843)
Negative regulation of synaptic transmission, gabaergic
(GO:0032229)
Nerve development
(GO:0021675)
Nerve growth factor receptor binding
(GO:0005163)
Nerve growth factor signaling pathway
(GO:0038180)
Nervous system development
(GO:0007399)
Neuron apoptotic process
(GO:0051402)
Neuron differentiation
(GO:0030182)
Neuron projection extension
(GO:1990138)
Neuron projection morphogenesis
(GO:0048812)
Neuron recognition
(GO:0008038)
Neurotrophin trkb receptor binding
(GO:0005169)
Peripheral nervous system development
(GO:0007422)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of collateral sprouting
(GO:0048672)
Positive regulation of long-term neuronal synaptic plasticity
(GO:0048170)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of synapse assembly
(GO:0051965)
Regeneration
(GO:0031099)
Regulation of axon extension
(GO:0030516)
Regulation of collateral sprouting
(GO:0048670)
Regulation of long-term neuronal synaptic plasticity
(GO:0048169)
Regulation of neuron apoptotic process
(GO:0043523)
Regulation of neuron differentiation
(GO:0045664)
Regulation of retinal cell programmed cell death
(GO:0046668)
Regulation of short-term neuronal synaptic plasticity
(GO:0048172)
Regulation of synaptic plasticity
(GO:0048167)
Response to activity
(GO:0014823)
Response to anesthetic
(GO:0072347)
Response to auditory stimulus
(GO:0010996)
Response to electrical stimulus
(GO:0051602)
Response to ethanol
(GO:0045471)
Response to food
(GO:0032094)
Response to hormone
(GO:0009725)
Response to hyperoxia
(GO:0055093)
Response to hypoxia
(GO:0001666)
Response to l-glutamate
(GO:1902065)
Response to light intensity
(GO:0009642)
Response to light stimulus
(GO:0009416)
Response to nerve growth factor
(GO:1990089)
Response to nutrient levels
(GO:0031667)
Response to potassium ion
(GO:0035864)
Response to tumor necrosis factor
(GO:0034612)
Response to vitamin a
(GO:0033189)
Response to xenobiotic stimulus
(GO:0009410)
Retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission
(GO:0099083)
Signal transduction
(GO:0007165)
Synapse assembly
(GO:0007416)
Taste bud development
(GO:0061193)
Trans-synaptic signaling by bdnf, modulating synaptic transmission
(GO:0099183)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Ureteric bud development
(GO:0001657)

Other Information

Proteins

Genular Protein ID: 470421745

Symbol: BDNF_RAT

Name: Brain-derived neurotrophic factor

UniProtKB Accession Codes:

P23363 Q53YL8

Database IDs:

Citations:

PubMed ID: 1889806

Title: Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations.

PubMed ID: 1889806

DOI: 10.1016/0888-7543(91)90436-i

PubMed ID: 1446835

Title: A rat brain-derived neurotrophic factor-encoding gene generates multiple transcripts through alternative use of 5' exons and polyadenylation sites.

PubMed ID: 1446835

DOI: 10.1016/0378-1119(92)90148-i

PubMed ID: 1966766

Title: Neurotrophic factors, their receptors, and the signal transduction pathways they activate.

PubMed ID: 1966766

DOI: 10.1101/sqb.1990.055.01.038

PubMed ID: 16376315

Title: Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine.

PubMed ID: 16376315

DOI: 10.1016/j.brainres.2005.10.004

PubMed ID: 17149751

Title: Mouse and rat BDNF gene structure and expression revisited.

PubMed ID: 17149751

DOI: 10.1002/jnr.21139

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8461137

Title: Multiple promoters direct tissue-specific expression of the rat BDNF gene.

PubMed ID: 8461137

DOI: 10.1016/0896-6273(93)90335-o

PubMed ID: 2025430

Title: Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary.

PubMed ID: 2025430

DOI: 10.1016/0896-6273(91)90180-8

Sequence Information:

Length: 249
Mass: 28109
Checksum: F9CAAA5DEF9A78B7
Sequence:

MTILFLTMVI SYFGCMKAAP MKEANVHGQG NLAYPAVRTH GTLESVNGPR AGSRGLTTTS 
LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS QVPLEPPLLF LLEEYKNYLD 
AANMSMRVRR HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE KVPVSKGQLK 
QYFYETKCNP MGYTKEGCRG IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV 
CTLTIKRGR

Genular Protein ID: 335163813

Symbol: A0A0G2K624_RAT

Name: N/A

UniProtKB Accession Codes:

A0A0G2K624

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 257
Mass: 29163
Checksum: 2CA3DE0526ECB889
Sequence:

MFHQVRRVMT ILFLTMVISY FGCMKAAPMK EANVHGQGNL AYPAVRTHGT LESVNGPRAG 
SRGLTTTSLA DTFEHVIEEL LDEDQKVRPN EENHKDADLY TSRVMLSSQV PLEPPLLFLL 
EEYKNYLDAA NMSMRVRRHS DPARRGELSV CDSISEWVTA ADKKTAVDMS GGTVTVLEKV 
PVSKGQLKQY FYETKCNPMG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DSKKRIGWRF 
IRIDTSCVCT LTIKRGR

Genular Protein ID: 1210474610

Symbol: A0A0H2UI28_RAT

Name: N/A

UniProtKB Accession Codes:

A0A0H2UI28

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 362
Mass: 40637
Checksum: C7AC82D8B6168E9E
Sequence:

MSDPSAWRWL SSGCPPLPPR RGAPAGWLSH GPHCARDSPA WRRKPPGAAR HLRLAGFDET 
GFPQLATAAL GQTRKRTGPR AGRRDQERDN NVTPLPGIRE LCVDPEFHQV RRVMTILFLT 
MVISYFGCMK AAPMKEANVH GQGNLAYPAV RTHGTLESVN GPRAGSRGLT TTSLADTFEH 
VIEELLDEDQ KVRPNEENHK DADLYTSRVM LSSQVPLEPP LLFLLEEYKN YLDAANMSMR 
VRRHSDPARR GELSVCDSIS EWVTAADKKT AVDMSGGTVT VLEKVPVSKG QLKQYFYETK 
CNPMGYTKEG CRGIDKRHWN SQCRTTQSYV RALTMDSKKR IGWRFIRIDT SCVCTLTIKR 
GR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bdnf

Associated with

Other Information

Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. PubMed ID: 1889806

A rat brain-derived neurotrophic factor-encoding gene generates multiple transcripts through alternative use of 5' exons and polyadenylation sites. PubMed ID: 1446835

Neurotrophic factors, their receptors, and the signal transduction pathways they activate. PubMed ID: 1966766

Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. PubMed ID: 16376315

Mouse and rat BDNF gene structure and expression revisited. PubMed ID: 17149751

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Multiple promoters direct tissue-specific expression of the rat BDNF gene. PubMed ID: 8461137

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. PubMed ID: 2025430

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

Database document:

PubMed ID: 1889806

PubMed ID: 1446835

PubMed ID: 1966766

PubMed ID: 16376315

PubMed ID: 17149751

PubMed ID: 15489334

PubMed ID: 8461137

PubMed ID: 2025430

PubMed ID: 15057822

PubMed ID: 15057822