Genular: Defining Cellular Identity and Function

Details for: C3

Gene ID: 24232

Symbol: C3

Ensembl ID: ENSRNOG00000046834

Description: complement C3

Associated with

Activation of c3 and c5
(R-RNO-174577)
Adaptive immune system
(R-RNO-1280218)
Alternative complement activation
(R-RNO-173736)
Class a/1 (rhodopsin-like receptors)
(R-RNO-373076)
Complement cascade
(R-RNO-166658)
G alpha (i) signalling events
(R-RNO-418594)
Gpcr downstream signalling
(R-RNO-388396)
Gpcr ligand binding
(R-RNO-500792)
Immune system
(R-RNO-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-RNO-198933)
Initial triggering of complement
(R-RNO-166663)
Innate immune system
(R-RNO-168249)
Metabolism of proteins
(R-RNO-392499)
Neutrophil degranulation
(R-RNO-6798695)
Peptide ligand-binding receptors
(R-RNO-375276)
Post-translational protein modification
(R-RNO-597592)
Post-translational protein phosphorylation
(R-RNO-8957275)
Regulation of complement cascade
(R-RNO-977606)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-RNO-381426)
Signaling by gpcr
(R-RNO-372790)
Signal transduction
(R-RNO-162582)
Amyloid-beta clearance
(GO:0097242)
C5l2 anaphylatoxin chemotactic receptor binding
(GO:0031715)
Cell surface
(GO:0009986)
Chemotaxis
(GO:0006935)
Complement-dependent cytotoxicity
(GO:0097278)
Complement-mediated synapse pruning
(GO:0150062)
Complement activation
(GO:0006956)
Complement activation, alternative pathway
(GO:0006957)
Complement activation, classical pathway
(GO:0006958)
Complement receptor mediated signaling pathway
(GO:0002430)
Endopeptidase inhibitor activity
(GO:0004866)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fatty acid metabolic process
(GO:0006631)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Lipid binding
(GO:0008289)
Neuron remodeling
(GO:0016322)
Oviduct epithelium development
(GO:0035846)
Positive regulation of activation of membrane attack complex
(GO:0001970)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of apoptotic cell clearance
(GO:2000427)
Positive regulation of developmental growth
(GO:0048639)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of glucose transmembrane transport
(GO:0010828)
Positive regulation of g protein-coupled receptor signaling pathway
(GO:0045745)
Positive regulation of lipid storage
(GO:0010884)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of phagocytosis, engulfment
(GO:0060100)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Positive regulation of type iia hypersensitivity
(GO:0001798)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Regulation of triglyceride biosynthetic process
(GO:0010866)
Response to bacterium
(GO:0009617)
Response to estradiol
(GO:0032355)
Response to estrogen
(GO:0043627)
Response to glucocorticoid
(GO:0051384)
Response to magnesium ion
(GO:0032026)
Response to progesterone
(GO:0032570)
Response to xenobiotic stimulus
(GO:0009410)
Retina development in camera-type eye
(GO:0060041)
Tolerance induction
(GO:0002507)
Vascular associated smooth muscle cell differentiation
(GO:0035886)
Vertebrate eye-specific patterning
(GO:0150064)

Other Information

Proteins

Complement C3
A6KQR3_RAT

Genular Protein ID: 4225396255

Symbol: CO3_RAT

Name: Complement C3

UniProtKB Accession Codes:

P01026 Q9ET19 Q9QV57 Q9QV58

Database IDs:

Citations:

PubMed ID: 2336397

Title: Nucleotide and deduced amino acid sequence of rat complement C3.

PubMed ID: 2336397

DOI: 10.1093/nar/18.8.2178

PubMed ID: 8352775

Title: Complement component C3-derived neutrophil chemotactic factors purified from exudate of rat carrageenin-induced inflammation.

PubMed ID: 8352775

DOI: 10.1006/bbrc.1993.1947

PubMed ID: 309768

Title: Purification, characterization, and amino acid sequence of rat anaphylatoxin (C3a).

PubMed ID: 309768

DOI: 10.1021/bi00616a027

PubMed ID: 10825534

Title: Structure at 1.44 A resolution of an N-terminally truncated form of the rat serum complement C3d fragment.

PubMed ID: 10825534

DOI: 10.1016/s0167-4838(00)00040-6

PubMed ID: 2674144

Title: Estrogen regulation of tissue-specific expression of complement C3.

PubMed ID: 2674144

DOI: 10.1016/s0021-9258(19)84798-1

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 1663
Mass: 186460
Checksum: 2F87CCB143CDD4BC
Sequence:

MGPTSGSQLL VLLLLLASSL LALGSPMYSI ITPNVLRLES EETFILEAHD AQGDVPVTVT 
VQDFLKKQVL TSEKTVLTGA TGHLNRVFIK IPASKEFNAD KGHKYVTVVA NFGATVVEKA 
VLVSFQSGYL FIQTDKTIYT PGSTVFYRIF TVDNNLLPVG KTVVIVIETP DGVPIKRDIL 
SSHNQYGILP LSWNIPELVN MGQWKIRAFY EHAPKQTFSA EFEVKEYVLP SFEVLVEPTE 
KFYYIHGPKG LEVSITARFL YGKNVDGTAF VIFGVQDEDK KISLALSLTR VLIEDGSGEA 
VLSRKVLMDG VRPSSPEALV GKSLYVSVTV ILHSGSDMVE AERSGIPIVT SPYQIHFTKT 
PKFFKPAMPF DLMVFVTNPD GSPARRVPVV TQGSDAQALT QDDGVAKLSV NTPNNRQPLT 
ITVSTKKEGI PDARQATRTM QAQPYSTMHN SNNYLHLSVS RVELKPGDNL NVNFHLRTDA 
GQEAKIRYYT YLVMNKGKLL KAGRQVREPG QDLVVLSLPI TPEFIPSFRL VAYYTLIGAN 
GQREVVADSV WVDVKDSCVG TLVVKGDPRD NRQPAPGHQT TLRIEGNQGA RVGLVAVDKG 
VFVLNKKNKL TQSKIWDVVE KADIGCTPGS GKNYAGVFMD AGLTFKTNQG LQTDQREDPE 
CAKPAARRRR SVQLMERRMD KAGQYTDKGL RKCCEDGMRD IPMPYSCQRR ARLITQGESC 
LKAFMDCCNY ITKLREQHRR DHVLGLARSD VDEDIIPEED IISRSHFPES WLWTIEELKE 
PEKNGISTKV MNIFLKDSIT TWEILAVSLS DKKGICVADP YEITVMQDFF IDLRLPYSVV 
RNEQVEIRAV LFNYREQEKL KVRVELLHNP AFCSMATAKK RYYQTIEIPP KSSVAVPYVI 
VPLKIGLQEV EVKAAVFNHF ISDGVKKILK VVPEGMRVNK TVAVRTLDPE HLNQGGVQRE 
DVNAADLSDQ VPDTDSETRI LLQGTPVAQM AEDAVDGERL KHLIVTPSGC GEQNMIGMTP 
TVIAVHYLDQ TEQWEKFGLE KRQEALELIK KGYTQQLAFK QPISAYAAFN NRPPSTWLTA 
MWSRSFSLAA NLIAIDSQVL CGAVKWLILE KQKPDGVFQE DGPVIHQEMI GGFRNTKEAD 
VSLTAFVLIA LQEARDICEG QVNSLPGSIN KAGEYLEASY LNLQRPYTVA IAGYALALMN 
KLEEPYLTKF LNTAKDRNRW EEPGQQLYNV EATSYALLAL LLLKDFDSVP PVVRWLNDER 
YYGGGYGSTQ ATFMVFQALA QYRADVPDHK DLNMDVSLHL PSRSSPTVFR LLWESGSLLR 
SEETKQNEGF SLTAKGKGQG TLSVVTVYHA KVKGKTTCKK FDLRVTIKPA PETAKKPQDA 
KSSMILDICT RYLGDVDATM SILDISMMTG FIPDTNDLEL LSSGVDRYIS KYEMDKAFSN 
KNTLIIYLEK ISHSEEDCLS FKVHQFFNVG LIQPGSVKVY SYYNLEESCT RFYHPEKDDG 
MLSKLCHNEM CRCAEENCFM HQSQDQVSLN ERLDKACEPG VDYVYKTKLT TIELSDDFDE 
YIMTIEQVIK SGSDEVQAGQ ERRFISHVKC RNALKLQKGK QYLMWGLSSD LWGEKPNTSY 
IIGKDTWVEH WPEAEERQDQ KNQKQCEDLG AFTETMVVFG CPN

Genular Protein ID: 1664685597

Symbol: A6KQR3_RAT

Name: N/A

UniProtKB Accession Codes:

A6KQR3

Database IDs:

Citations:

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

Sequence Information:

Length: 1663
Mass: 186324
Checksum: 37CCB03B78072FAF
Sequence:

MGPTSGSQLL VLLLLLASSL LALGSPMYSI ITPNVLRLES EETFILEAHD AQGDVPVTVT 
VQDFLKKQVL TSEKTVLTGA TGHLNRVSIK IPASKEFNAD KGHKYVTVVA NFGATVVEKA 
VLVSFQSGYL FIQTDKTIYT PGSTVFYRIF TVDNNLLPVG KTVVIVIETP DGVPIKRDIL 
SSHNQYGILP LSWNIPELVN MGQWKIRAFY EHAPKQTFSA EFEVKEYVLP SFEVLVEPTE 
KFYYIDDPKG LEVSITARFL YGKNVDGTAF VIFGVQDEDK KISLAQSLTR VLIEDGSGEA 
VLSRKVLMDG VRPSSPEALV GKSLYVSVTV ILHSGSDMVE AERSGIPIVT SPYQIHFTKT 
PKFFKPAMPF DLMVFVTNPD GSPARRVPVV TQGSDAQALT QDDGVAKLSV NTPNNRQPLT 
ITVRTKKEGI PDARQATRTM QAQPYSTMHN SNNYLHLSVS RVELKPGDNL NVNFHLRTDA 
GQEAKIRYYT YLVMNKGKLL KAGRQVREPG QDLVVLSLPI TPEFIPSFRL VAYYTLIGAN 
GQREVVADSV WVDVKDSCVG TLVVKGDPRD NRQPAPGHQT TLRIEGNQGA RVGLVAVDKG 
VFVLNKKNKL TQSKIWDVVE KADIGCTPGS GKNYAGVFMD AGLTFKTNQG LQTDQREDPE 
CAKPAARRRR SVQLMERRMD KAGQYTDKGL RKCCEDGMRD IPMKYSCQRR ARLITQGESC 
LKAFMDCCNY ITKLREQHRR DHVLGLARSD VDEDIIPEED IISRSHFPES WLWTIEELKE 
PEKNGISTKV MNIFLKDSIT TWEILAVSLS DKKGICVADP YEITVMQDFF IDLRLPYSVV 
RNEQVEIRAV LFNYREQEKL KVRVELLHNP AFCSMATAKK RYYQTIEIPP KSSVAVPYVI 
VPLKIGLQEV EVKAAVFNHF ISDGVKKILK VVPEGMRVNK TVAVRTLDPE HLGQGGVQRE 
DVPAADLSDQ VPDTDSETRI LLQGTPVAQM AEDAVDGERL KHLIVTPSGC GEQNMIGMTP 
TVIAVHYLDQ TEQWEKFGLE KRQEALELIK KGYTQQLAFK QPSSAYAAFN NRPPSTWLTA 
YVVKVFSLAA NLIAIDSQVL CGAVKWLILE KQKPDGVFQE DGPVIHQEMI GGFRNTKEAD 
VSLTAFVLIA LQEARDICEG QVNSLPGSIN KAGEYLEASY LNLQRPYTVA IAGYALALMN 
KLEEPYLTKF LNTAKDRNRW EEPGQQLYNV EATSYALLAL LLLKDFDSVP PVVRWLNEQR 
YYGGGYGSTQ ATFMVFQALA QYQTDVPDHK DLNMDVSLHL PSRSSPTVFR LLWESGSLLR 
SEETKQNEGF SLTAKGKGQG TLSVVTVYHA KVKGKATCKK FDLRVTIKPA PETAKKPQDA 
KSSMILDICT RYLGDVDATM SILDISMMTG FIPDTNDLEL LSSGVDRYIS KYEMDKAFSN 
KNTLIIYLEK ISHSEEDCLS FKVHQFFNVG LIQPGSVKVY SYYNLEESCT RFYHPEKDDG 
MLSKLCHNEM CRCAEENCFM HQSQDQVSLN ERLDKACEPG VDYVYKTKLT TIELSDDFDE 
YIMTIEQVIK SGSDEVQAGQ ERRFISHVKC RNALKLQKGK QYLMWGLSSD LWGEKPNTSY 
IIGKDTWVEH WPEAEECQDQ KNQKQCEDLG AFTETMVVFG CPN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: C3

Associated with

Other Information

Nucleotide and deduced amino acid sequence of rat complement C3. PubMed ID: 2336397

Complement component C3-derived neutrophil chemotactic factors purified from exudate of rat carrageenin-induced inflammation. PubMed ID: 8352775

Purification, characterization, and amino acid sequence of rat anaphylatoxin (C3a). PubMed ID: 309768

Structure at 1.44 A resolution of an N-terminally truncated form of the rat serum complement C3d fragment. PubMed ID: 10825534

Estrogen regulation of tissue-specific expression of complement C3. PubMed ID: 2674144

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Gene and alternative splicing annotation with AIR. PubMed ID: 15632090