Genular: Defining Cellular Identity and Function

Details for: Camk2d

Gene ID: 24246

Symbol: Camk2d

Ensembl ID: ENSRNOG00000011589

Description: calcium/calmodulin-dependent protein kinase II delta

Associated with

Activation of nmda receptors and postsynaptic events
(R-RNO-442755)
Cardiac conduction
(R-RNO-5576891)
Cellular responses to stimuli
(R-RNO-8953897)
Cellular responses to stress
(R-RNO-2262752)
Cellular response to heat stress
(R-RNO-3371556)
Cytokine signaling in immune system
(R-RNO-1280215)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-RNO-399721)
Hsf1-dependent transactivation
(R-RNO-3371571)
Immune system
(R-RNO-168256)
Interferon gamma signaling
(R-RNO-877300)
Interferon signaling
(R-RNO-913531)
Ion channel transport
(R-RNO-983712)
Ion homeostasis
(R-RNO-5578775)
Ion transport by p-type atpases
(R-RNO-936837)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Muscle contraction
(R-RNO-397014)
Neuronal system
(R-RNO-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-RNO-112314)
Raf/map kinase cascade
(R-RNO-5673001)
Raf activation
(R-RNO-5673000)
Signal transduction
(R-RNO-162582)
Trafficking of ampa receptors
(R-RNO-399719)
Transmission across chemical synapses
(R-RNO-112315)
Transport of small molecules
(R-RNO-382551)
Unblocking of nmda receptors, glutamate binding and activation
(R-RNO-438066)
Atp binding
(GO:0005524)
Axon initial segment
(GO:0043194)
Calcium- and calmodulin-dependent protein kinase complex
(GO:0005954)
Calcium ion transport
(GO:0006816)
Calmodulin-dependent protein kinase activity
(GO:0004683)
Calmodulin binding
(GO:0005516)
Cardiac muscle cell contraction
(GO:0086003)
Cardiac muscle contraction
(GO:0060048)
Cell growth involved in cardiac muscle cell development
(GO:0061049)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum calcium ion homeostasis
(GO:0032469)
G1/s transition of mitotic cell cycle
(GO:0000082)
Identical protein binding
(GO:0042802)
Intercalated disc
(GO:0014704)
Intracellular potassium ion homeostasis
(GO:0030007)
Negative regulation of sodium ion transmembrane transport
(GO:1902306)
Neuromuscular junction
(GO:0031594)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Nitric-oxide synthase binding
(GO:0050998)
Nucleus
(GO:0005634)
Organelle
(GO:0043226)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of cardiac muscle cell apoptotic process
(GO:0010666)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of dna biosynthetic process
(GO:2000573)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Positive regulation of rac protein signal transduction
(GO:0035022)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of vascular associated smooth muscle cell proliferation
(GO:1904707)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
(GO:1902514)
Regulation of cardiac muscle cell action potential
(GO:0098901)
Regulation of cardiac muscle cell action potential involved in regulation of contraction
(GO:0098909)
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
(GO:0010881)
Regulation of cell communication by electrical coupling
(GO:0010649)
Regulation of cell communication by electrical coupling involved in cardiac conduction
(GO:1901844)
Regulation of cellular localization
(GO:0060341)
Regulation of membrane depolarization
(GO:0003254)
Regulation of protein localization to plasma membrane
(GO:1903076)
Regulation of relaxation of cardiac muscle
(GO:1901897)
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
(GO:0010880)
Regulation of sodium ion transport
(GO:0002028)
Relaxation of cardiac muscle
(GO:0055119)
Response to hypoxia
(GO:0001666)
Sarcolemma
(GO:0042383)
Sarcoplasmic reticulum
(GO:0016529)
Sarcoplasmic reticulum membrane
(GO:0033017)
Sodium channel inhibitor activity
(GO:0019871)
T-tubule
(GO:0030315)
Titin binding
(GO:0031432)
Transmembrane transporter binding
(GO:0044325)

Other Information

Proteins

Calcium/calmodulin-dependent protein kinase type II subunit delta

Genular Protein ID: 246600142

Symbol: KCC2D_RAT

Name: Calcium/calmodulin-dependent protein kinase type II subunit delta

UniProtKB Accession Codes:

P15791 P97915 P97916 Q3B7L0 Q63904 Q63905 Q63906 Q63907 Q63908

Database IDs:

Citations:

PubMed ID: 2553697

Title: Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs.

PubMed ID: 2553697

DOI: 10.1016/s0021-9258(19)84658-6

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8390994

Title: Identification of novel isoforms of the delta subunit of Ca2+/calmodulin-dependent protein kinase II. Differential expression in rat brain and aorta.

PubMed ID: 8390994

DOI: 10.1016/s0021-9258(19)85259-6

PubMed ID: 8224201

Title: New isoforms of multifunctional calcium/calmodulin-dependent protein kinase II.

PubMed ID: 8224201

DOI: 10.1016/0014-5793(93)80678-n

PubMed ID: 10825152

Title: Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytes.

PubMed ID: 10825152

DOI: 10.1074/jbc.c000253200

PubMed ID: 16891908

Title: Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy.

PubMed ID: 16891908

DOI: 10.1097/01.fjc.0000211796.45281.46

PubMed ID: 18056528

Title: Rad GTPase deficiency leads to cardiac hypertrophy.

PubMed ID: 18056528

DOI: 10.1161/circulationaha.107.707257

PubMed ID: 17923476

Title: CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses.

PubMed ID: 17923476

DOI: 10.1074/jbc.m707083200

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 533
Mass: 60081
Checksum: E41BCB2B5A00E7CA
Sequence:

MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 
EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 
LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 
LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 
VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 
KGAILTTMLA TRNFSAAKSL LKKPDGVKIN NKANVVTSPK ENIPTPALEP QTTVIHNPDG 
NKESTESSNT TIEDEDVKAR KQEIIKVTEQ LIEAINNGDF EAYTKICDPG LTAFEPEALG 
NLVEGMDFHR FYFENALPKI NKPIHTIILN PHVHLVGDDA ACIAYIRLTQ YMDGNGMPKT 
MQSEETRVWH RRDGKWQNIH FHRSGSPTVP IKPPCIPNGK ENFSGGTSLW QNI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Camk2d

Associated with

Other Information

Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs. PubMed ID: 2553697

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of novel isoforms of the delta subunit of Ca2+/calmodulin-dependent protein kinase II. Differential expression in rat brain and aorta. PubMed ID: 8390994

New isoforms of multifunctional calcium/calmodulin-dependent protein kinase II. PubMed ID: 8224201

Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytes. PubMed ID: 10825152

Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy. PubMed ID: 16891908

Rad GTPase deficiency leads to cardiac hypertrophy. PubMed ID: 18056528

CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. PubMed ID: 17923476

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903