Genular: Defining Cellular Identity and Function

Details for: Casr

Gene ID: 24247

Symbol: Casr

Ensembl ID: ENSRNOG00000002265

Description: calcium-sensing receptor

Associated with

Class c/3 (metabotropic glutamate/pheromone receptors)
(R-RNO-420499)
G alpha (i) signalling events
(R-RNO-418594)
G alpha (q) signalling events
(R-RNO-416476)
Gpcr downstream signalling
(R-RNO-388396)
Gpcr ligand binding
(R-RNO-500792)
Signaling by gpcr
(R-RNO-372790)
Signal transduction
(R-RNO-162582)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Amino acid binding
(GO:0016597)
Apical plasma membrane
(GO:0016324)
Axon
(GO:0030424)
Axon terminus
(GO:0043679)
Basolateral plasma membrane
(GO:0016323)
Bile acid secretion
(GO:0032782)
Branching morphogenesis of an epithelial tube
(GO:0048754)
Calcium ion binding
(GO:0005509)
Calcium ion import
(GO:0070509)
Cell surface
(GO:0009986)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to hepatocyte growth factor stimulus
(GO:0035729)
Cellular response to hypoxia
(GO:0071456)
Cellular response to low-density lipoprotein particle stimulus
(GO:0071404)
Cellular response to peptide
(GO:1901653)
Cellular response to vitamin d
(GO:0071305)
Chloride transmembrane transport
(GO:1902476)
Detection of calcium ion
(GO:0005513)
Fat pad development
(GO:0060613)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Identical protein binding
(GO:0042802)
Integrin binding
(GO:0005178)
Intracellular calcium ion homeostasis
(GO:0006874)
Jnk cascade
(GO:0007254)
Metal ion binding
(GO:0046872)
Neuronal cell body
(GO:0043025)
Ossification
(GO:0001503)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive regulation of calcium ion import
(GO:0090280)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of positive chemotaxis
(GO:0050927)
Positive regulation of vasoconstriction
(GO:0045907)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Regulation of calcium ion transport
(GO:0051924)
Response to calcium ion
(GO:0051592)
Response to fibroblast growth factor
(GO:0071774)
Response to ischemia
(GO:0002931)
Response to metal ion
(GO:0010038)
Response to organic cyclic compound
(GO:0014070)
Transmembrane transporter binding
(GO:0044325)
Vasodilation
(GO:0042311)

Other Information

Proteins

Extracellular calcium-sensing receptor

Genular Protein ID: 3421548328

Symbol: CASR_RAT

Name: Extracellular calcium-sensing receptor

UniProtKB Accession Codes:

P48442

Database IDs:

Citations:

PubMed ID: 7816802

Title: Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor.

PubMed ID: 7816802

DOI: 10.1073/pnas.92.1.131

PubMed ID: 7724534

Title: Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals.

PubMed ID: 7724534

DOI: 10.1073/pnas.92.8.3161

PubMed ID: 17623778

Title: The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network.

PubMed ID: 17623778

DOI: 10.1242/jcs.03469

Sequence Information:

Length: 1079
Mass: 120868
Checksum: D7664550361F9736
Sequence:

MASYSCCLAL LALAWHSSAY GPDQRAQKKG DIILGGLFPI HFGVAAKDQD LKSRPESVEC 
IRYNFRGFRW LQAMIFAIEE INSSPSLLPN MTLGYRIFDT CNTVSKALEA TLSFVAQNKI 
DSLNLDEFCN CSEHIPSTIA VVGATGSGVS TAVANLLGLF YIPQVSYASS SRLLSNKNQY 
KSFLRTIPND EHQATAMADI IEYFRWNWVG TIAADDDYGR PGIEKFREEA EERDICIDFS 
ELISQYSDEE EIQQVVEVIQ NSTAKVIVVF SSGPDLEPLI KEIVRRNITG RIWLASEAWA 
SSSLIAMPEY FHVVGGTIGF GLKAGQIPGF REFLQKVHPR KSVHNGFAKE FWEETFNCHL 
QEGAKGPLPV DTFVRSHEEG GNRLLNSSTA FRPLCTGDEN INSVETPYMD YEHLRISYNV 
YLAVYSIAHA LQDIYTCLPG RGLFTNGSCA DIKKVEAWQV LKHLRHLNFT NNMGEQVTFD 
ECGDLVGNYS IINWHLSPED GSIVFKEVGY YNVYAKKGER LFINEEKILW SGFSREVPFS 
NCSRDCQAGT RKGIIEGEPT CCFECVECPD GEYSGETDAS ACDKCPDDFW SNENHTSCIA 
KEIEFLAWTE PFGIALTLFA VLGIFLTAFV LGVFIKFRNT PIVKATNREL SYLLLFSLLC 
CFSSSLFFIG EPQDWTCRLR QPAFGISFVL CISCILVKTN RVLLVFEAKI PTSFHRKWWG 
LNLQFLLVFL CTFMQILICI IWLYTAPPSS YRNHELEDEI IFITCHEGSL MALGSLIGYT 
CLLAAICFFF AFKSRKLPEN FNEAKFITFS MLIFFIVWIS FIPAYASTYG KFVSAVEVIA 
ILAASFGLLA CIFFNKVYII LFKPSRNTIE EVRSSTAAHA FKVAARATLR RPNISRKRSS 
SLGGSTGSIP SSSISSKSNS EDRFPQPERQ KQQQPLSLTQ QEQQQQPLTL HPQQQQQPQQ 
PRCKQKVIFG SGTVTFSLSF DEPQKNAMAH RNSMRQNSLE AQRSNDTLGR HQALLPLQCA 
DADSEMTIQE TGLQGPMVGD HQPEMESSDE MSPALVMSTS RSFVISGGGS SVTENVLHS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.