Genular: Defining Cellular Identity and Function

Details for: Cebpa

Gene ID: 24252

Symbol: Cebpa

Description: CCAAT/enhancer binding protein alpha

Associated with

Acute-phase response
(GO:0006953)
Animal organ regeneration
(GO:0031100)
Brown fat cell differentiation
(GO:0050873)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Cellular response to lithium ion
(GO:0071285)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cholesterol metabolic process
(GO:0008203)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna-templated transcription
(GO:0006351)
Dna binding
(GO:0003677)
Embryonic placenta development
(GO:0001892)
Epithelial cell maturation
(GO:0002070)
Fat cell differentiation
(GO:0045444)
Glucose homeostasis
(GO:0042593)
Granulocyte differentiation
(GO:0030851)
Hematopoietic stem cell proliferation
(GO:0071425)
Histone deacetylase binding
(GO:0042826)
Hmg box domain binding
(GO:0071837)
Identical protein binding
(GO:0042802)
Inner ear development
(GO:0048839)
Interleukin-6-mediated signaling pathway
(GO:0070102)
Kinase binding
(GO:0019900)
Lipid homeostasis
(GO:0055088)
Liver development
(GO:0001889)
Lung development
(GO:0030324)
Macrophage differentiation
(GO:0030225)
Memory
(GO:0007613)
Mitochondrion organization
(GO:0007005)
Myeloid cell differentiation
(GO:0030099)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of hematopoietic stem cell proliferation
(GO:1902034)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notch signaling pathway
(GO:0007219)
Nuclear matrix
(GO:0016363)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Osteoblast development
(GO:0002076)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna-templated transcription initiation
(GO:2000144)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of macrophage activation
(GO:0043032)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Rb-e2f complex
(GO:0035189)
Regulation of cell population proliferation
(GO:0042127)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to dexamethasone
(GO:0071548)
Response to nutrient
(GO:0007584)
Response to phenylpropanoid
(GO:0080184)
Response to vitamin b2
(GO:0033274)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase i transcription regulatory region sequence-specific dna binding
(GO:0001163)
Sequence-specific dna binding
(GO:0043565)
Stat family protein binding
(GO:0097677)
Transcription by rna polymerase i
(GO:0006360)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription regulator complex
(GO:0005667)
Urea cycle
(GO:0000050)
White fat cell differentiation
(GO:0050872)

Other Information

Proteins

CEBPA_RAT

Genular Protein ID: 4053048614

Symbol: CEBPA_RAT

Name: N/A

UniProtKB Accession Codes:

P05554

Database IDs:

Citations:

PubMed ID: 2850264

Title: Isolation of a recombinant copy of the gene encoding C/EBP.

PubMed ID: 2850264

DOI: 10.1101/gad.2.7.786

PubMed ID: 7926792

Title: A revised sequence of the rat c/ebp gene.

PubMed ID: 7926792

DOI: 10.1101/gad.8.9.1131

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

PubMed ID: 1884998

Title: A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.

PubMed ID: 1884998

DOI: 10.1101/gad.5.9.1553

PubMed ID: 1377818

Title: Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma.

PubMed ID: 1377818

DOI: 10.1093/nar/20.12.3091

PubMed ID: 8367486

Title: CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials.

PubMed ID: 8367486

DOI: 10.1073/pnas.90.17.8219

PubMed ID: 11672531

Title: E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo.

PubMed ID: 11672531

DOI: 10.1016/s0092-8674(01)00516-5

PubMed ID: 16735515

Title: Sumoylation of CCAAT/enhancer-binding protein alpha and its functional roles in hepatocyte differentiation.

PubMed ID: 16735515

DOI: 10.1074/jbc.m600852200

PubMed ID: 20075868

Title: Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size.

PubMed ID: 20075868

DOI: 10.1038/emboj.2009.404

PubMed ID: 20176812

Title: Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes.

PubMed ID: 20176812

DOI: 10.1128/mcb.01619-09

PubMed ID: 12578822

Title: Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein alpha.

PubMed ID: 12578822

DOI: 10.1074/jbc.m300417200

Sequence Information:

Length: 358
Mass: 37371
Checksum: 4DA8F112F6EA95D0
Sequence:

MESADFYEAE PRPPMSSHLQ SPPHAPSNAA FGFPRGAGPA PPPAPPAAPE PLGGICEHET 
SIDISAYIDP AAFNDEFLAD LFQHSRQQEK AKAAAGPAGG GGDFDYPGAP AGPGGAVMSA 
GAHGPPPGYG CAAAGYLDGR LEPLYERVGA PALRPLVIKQ EPREEDEAKQ LALAGLFPYQ 
PPPPPPPPHP HASPAHLAAP HLQFQIAHCG QTTMHLQPGH PTPPPTPVPS PHPAPAMGAA 
GLPGPGGSLK GLAGPHPDLR TGGGGGGGAG AGKAKKSVDK NSNEYRVRRE RNNIAVRKSR 
DKAKQRNVET QQKVLELTSD NDRLRKRVEQ LSRELDTLRG IFRQLPESSL VKAMGNCA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cebpa

Associated with

Other Information

Isolation of a recombinant copy of the gene encoding C/EBP. PubMed ID: 2850264

A revised sequence of the rat c/ebp gene. PubMed ID: 7926792

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. PubMed ID: 1884998

Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma. PubMed ID: 1377818

CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials. PubMed ID: 8367486

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo. PubMed ID: 11672531

Sumoylation of CCAAT/enhancer-binding protein alpha and its functional roles in hepatocyte differentiation. PubMed ID: 16735515

Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size. PubMed ID: 20075868

Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. PubMed ID: 20176812

Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein alpha. PubMed ID: 12578822