Genular: Defining Cellular Identity and Function

Details for: Chrm3

Gene ID: 24260

Symbol: Chrm3

Ensembl ID: ENSRNOG00000049410

Description: cholinergic receptor, muscarinic 3

Associated with

Amine ligand-binding receptors
(R-RNO-375280)
Class a/1 (rhodopsin-like receptors)
(R-RNO-373076)
G alpha (q) signalling events
(R-RNO-416476)
Gpcr downstream signalling
(R-RNO-388396)
Gpcr ligand binding
(R-RNO-500792)
Muscarinic acetylcholine receptors
(R-RNO-390648)
Signaling by gpcr
(R-RNO-372790)
Signal transduction
(R-RNO-162582)
Acetylcholine binding
(GO:0042166)
Acetylcholine receptor signaling pathway
(GO:0095500)
Adenylate cyclase-inhibiting g protein-coupled acetylcholine receptor signaling pathway
(GO:0007197)
Asymmetric synapse
(GO:0032279)
Axon terminus
(GO:0043679)
Basal plasma membrane
(GO:0009925)
Basolateral plasma membrane
(GO:0016323)
Calcium-mediated signaling
(GO:0019722)
Chemical synaptic transmission
(GO:0007268)
Dendrite
(GO:0030425)
Endoplasmic reticulum membrane
(GO:0005789)
Glutamatergic synapse
(GO:0098978)
G protein-coupled acetylcholine receptor activity
(GO:0016907)
G protein-coupled acetylcholine receptor binding
(GO:0031789)
G protein-coupled acetylcholine receptor signaling pathway
(GO:0007213)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
G protein-coupled serotonin receptor activity
(GO:0004993)
G protein-coupled serotonin receptor signaling pathway
(GO:0098664)
Ion channel modulating, g protein-coupled receptor signaling pathway
(GO:0099105)
Ligand-gated ion channel signaling pathway
(GO:1990806)
Negative regulation of heart rate by acetylcholine
(GO:0003063)
Phospholipase c-activating g protein-coupled acetylcholine receptor signaling pathway
(GO:0007207)
Plasma membrane
(GO:0005886)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of smooth muscle contraction
(GO:0045987)
Positive regulation of vascular associated smooth muscle contraction
(GO:1904695)
Positive regulation of vasoconstriction
(GO:0045907)
Postsynaptic density membrane
(GO:0098839)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Quaternary ammonium group binding
(GO:0050997)
Regulation of vascular associated smooth muscle contraction
(GO:0003056)
Response to acetylcholine
(GO:1905144)
Saliva secretion
(GO:0046541)
Smooth muscle contraction
(GO:0006939)
Synapse
(GO:0045202)
Synaptic transmission, cholinergic
(GO:0007271)

Other Information

Proteins

Muscarinic acetylcholine receptor M3

Genular Protein ID: 574772979

Symbol: ACM3_RAT

Name: Muscarinic acetylcholine receptor M3

UniProtKB Accession Codes:

P08483 Q9QWK9

Database IDs:

Citations:

PubMed ID: 3037705

Title: Identification of a family of muscarinic acetylcholine receptor genes.

PubMed ID: 3037705

DOI: 10.1126/science.3037705

PubMed ID: 3272174

Title: Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes.

PubMed ID: 3272174

DOI: 10.1016/0896-6273(88)90190-0

PubMed ID: 3120722

Title: A novel subtype of muscarinic receptor identified by homology screening.

PubMed ID: 3120722

DOI: 10.1016/0006-291x(87)91613-5

PubMed ID: 9972520

Title: Molecular cloning of m3 muscarinic acetylcholine receptor in rat iris.

PubMed ID: 9972520

DOI: 10.1540/jsmr.34.111

PubMed ID: 2380182

Title: Muscarinic acetylcholine receptors. Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation.

PubMed ID: 2380182

DOI: 10.1016/s0021-9258(18)77406-1

PubMed ID: 1657592

Title: Site-directed mutagenesis of the m3 muscarinic receptor: identification of a series of threonine and tyrosine residues involved in agonist but not antagonist binding.

PubMed ID: 1657592

DOI: 10.1002/j.1460-2075.1991.tb04941.x

PubMed ID: 1527051

Title: Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation. A study with m3 muscarinic receptor point mutants.

PubMed ID: 1527051

DOI: 10.1016/s0021-9258(18)41776-0

PubMed ID: 22358844

Title: Structure and dynamics of the M3 muscarinic acetylcholine receptor.

PubMed ID: 22358844

DOI: 10.1038/nature10867

Sequence Information:

Length: 589
Mass: 66066
Checksum: 9A5EF2FA653C830A
Sequence:

MTLHSNSTTS PLFPNISSSW VHSPSEAGLP LGTVTQLGSY NISQETGNFS SNDTSSDPLG 
GHTIWQVVFI AFLTGFLALV TIIGNILVIV AFKVNKQLKT VNNYFLLSLA CADLIIGVIS 
MNLFTTYIIM NRWALGNLAC DLWLSIDYVA SNASVMNLLV ISFDRYFSIT RPLTYRAKRT 
TKRAGVMIGL AWVISFVLWA PAILFWQYFV GKRTVPPGEC FIQFLSEPTI TFGTAIAAFY 
MPVTIMTILY WRIYKETEKR TKELAGLQAS GTEAEAENFV HPTGSSRSCS SYELQQQGVK 
RSSRRKYGRC HFWFTTKSWK PSAEQMDQDH SSSDSWNNND AAASLENSAS SDEEDIGSET 
RAIYSIVLKL PGHSSILNST KLPSSDNLQV SNEDLGTVDV ERNAHKLQAQ KSMGDGDNCQ 
KDFTKLPIQL ESAVDTGKTS DTNSSADKTT ATLPLSFKEA TLAKRFALKT RSQITKRKRM 
SLIKEKKAAQ TLSAILLAFI ITWTPYNIMV LVNTFCDSCI PKTYWNLGYW LCYINSTVNP 
VCYALCNKTF RTTFKTLLLC QCDKRKRRKQ QYQQRQSVIF HKRVPEQAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Chrm3

Associated with

Other Information

Identification of a family of muscarinic acetylcholine receptor genes. PubMed ID: 3037705

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. PubMed ID: 3272174

A novel subtype of muscarinic receptor identified by homology screening. PubMed ID: 3120722

Molecular cloning of m3 muscarinic acetylcholine receptor in rat iris. PubMed ID: 9972520

Muscarinic acetylcholine receptors. Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation. PubMed ID: 2380182

Site-directed mutagenesis of the m3 muscarinic receptor: identification of a series of threonine and tyrosine residues involved in agonist but not antagonist binding. PubMed ID: 1657592

Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation. A study with m3 muscarinic receptor point mutants. PubMed ID: 1527051

Structure and dynamics of the M3 muscarinic acetylcholine receptor. PubMed ID: 22358844