Genular: Defining Cellular Identity and Function

Details for: Cyp1a1

Gene ID: 24296

Symbol: Cyp1a1

Ensembl ID: ENSRNOG00000019500

Description: cytochrome P450, family 1, subfamily a, polypeptide 1

Associated with

Arachidonic acid metabolism
(R-RNO-2142753)
Biological oxidations
(R-RNO-211859)
Biosynthesis of dha-derived spms
(R-RNO-9018677)
Biosynthesis of protectins
(R-RNO-9018681)
Biosynthesis of specialized proresolving mediators (spms)
(R-RNO-9018678)
Cytochrome p450 - arranged by substrate type
(R-RNO-211897)
Fatty acid metabolism
(R-RNO-8978868)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Phase i - functionalization of compounds
(R-RNO-211945)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (hete)
(R-RNO-2142816)
Synthesis of epoxy (eet) and dihydroxyeicosatrienoic acids (dhet)
(R-RNO-2142670)
Xenobiotics
(R-RNO-211981)
9-cis-retinoic acid biosynthetic process
(GO:0042904)
Amine metabolic process
(GO:0009308)
Arachidonic acid monooxygenase activity
(GO:0008391)
Aromatase activity
(GO:0070330)
Camera-type eye development
(GO:0043010)
Catalytic activity
(GO:0003824)
Cellular response to copper ion
(GO:0071280)
Cellular response to organic cyclic compound
(GO:0071407)
Coumarin metabolic process
(GO:0009804)
Demethylase activity
(GO:0032451)
Dibenzo-p-dioxin catabolic process
(GO:0019341)
Dibenzo-p-dioxin metabolic process
(GO:0018894)
Digestive tract development
(GO:0048565)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Estrogen 2-hydroxylase activity
(GO:0101021)
Estrogen 16-alpha-hydroxylase activity
(GO:0101020)
Estrogen metabolic process
(GO:0008210)
Fatty acid metabolic process
(GO:0006631)
Flavonoid 3'-monooxygenase activity
(GO:0016711)
Flavonoid metabolic process
(GO:0009812)
Heme binding
(GO:0020037)
Hepatocyte differentiation
(GO:0070365)
Heterocycle metabolic process
(GO:0046483)
Hsp70 protein binding
(GO:0030544)
Hsp90 protein binding
(GO:0051879)
Hydrogen peroxide biosynthetic process
(GO:0050665)
Hydroperoxy icosatetraenoate dehydratase activity
(GO:0106256)
Insecticide metabolic process
(GO:0017143)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Lipid hydroxylation
(GO:0002933)
Liver development
(GO:0001889)
Long-chain fatty acid metabolic process
(GO:0001676)
Long-chain fatty acid omega-1 hydroxylase activity
(GO:0120319)
Long-chain fatty acid omega-hydroxylase activity
(GO:0102033)
Maternal process involved in parturition
(GO:0060137)
Mitochondrial inner membrane
(GO:0005743)
Monooxygenase activity
(GO:0004497)
Nitric oxide metabolic process
(GO:0046209)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on diphenols and related substances as donors
(GO:0016679)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Porphyrin-containing compound metabolic process
(GO:0006778)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Protein binding
(GO:0005515)
Response to 3-methylcholanthrene
(GO:1904681)
Response to arsenic-containing substance
(GO:0046685)
Response to food
(GO:0032094)
Response to herbicide
(GO:0009635)
Response to hyperoxia
(GO:0055093)
Response to hypoxia
(GO:0001666)
Response to immobilization stress
(GO:0035902)
Response to iron(iii) ion
(GO:0010041)
Response to lipopolysaccharide
(GO:0032496)
Response to nematode
(GO:0009624)
Response to organic cyclic compound
(GO:0014070)
Response to organic substance
(GO:0010033)
Response to toxic substance
(GO:0009636)
Response to vitamin a
(GO:0033189)
Response to xenobiotic stimulus
(GO:0009410)
Retinol metabolic process
(GO:0042572)
Steroid biosynthetic process
(GO:0006694)
Steroid hydroxylase activity
(GO:0008395)
Steroid metabolic process
(GO:0008202)
Tissue remodeling
(GO:0048771)
Toxin metabolic process
(GO:0009404)
Vitamin d 24-hydroxylase activity
(GO:0070576)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

Cytochrome P450 1A1

Genular Protein ID: 1041062614

Symbol: CP1A1_RAT

Name: Cytochrome P450 1A1

UniProtKB Accession Codes:

P00185

Database IDs:

Citations:

PubMed ID: 6089174

Title: Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 genes in the rat.

PubMed ID: 6089174

DOI: 10.1073/pnas.81.16.5066

PubMed ID: 6324135

Title: Nucleotide sequence of a full-length cDNA coding for 3-methylcholanthrene-induced rat liver cytochrome P-450MC.

PubMed ID: 6324135

DOI: 10.1093/nar/12.6.2929

PubMed ID: 3838427

Title: Gene structure and nucleotide sequence for rat cytochrome P-450c.

PubMed ID: 3838427

DOI: 10.1016/0003-9861(85)90300-5

PubMed ID: 3718958

Title: Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450.

PubMed ID: 3718958

DOI: 10.1021/bi00357a015

PubMed ID: 3041969

Title: Effect of nutritional imbalances on cytochrome P-450 isozymes in rat liver.

PubMed ID: 3041969

DOI: 10.1016/0006-2952(88)90634-x

PubMed ID: 8651689

Title: Identification and characterization of cytochrome P4501A1 amino acid residues interacting with a radiolabeled photoaffinity diazido-benzphetamine analogue.

PubMed ID: 8651689

DOI: 10.1006/abbi.1996.0236

PubMed ID: 9348277

Title: Targeting of NH2-terminal-processed microsomal protein to mitochondria: a novel pathway for the biogenesis of hepatic mitochondrial P450MT2.

PubMed ID: 9348277

DOI: 10.1083/jcb.139.3.589

PubMed ID: 19401463

Title: Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism.

PubMed ID: 19401463

DOI: 10.1074/jbc.m109.007492

PubMed ID: 20972997

Title: Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards.

PubMed ID: 20972997

DOI: 10.1002/rcm.4760

PubMed ID: 24098488

Title: Discovery and confirmation of O-GlcNAcylated proteins in rat liver mitochondria by combination of mass spectrometry and immunological methods.

PubMed ID: 24098488

DOI: 10.1371/journal.pone.0076399

Sequence Information:

Length: 524
Mass: 59393
Checksum: C766DF8044D598C5
Sequence:

MPSVYGFPAF TSATELLLAV TTFCLGFWVV RVTRTWVPKG LKSPPGPWGL PFIGHVLTLG 
KNPHLSLTKL SQQYGDVLQI RIGSTPVVVL SGLNTIKQAL VKQGDDFKGR PDLYSFTLIA 
NGQSMTFNPD SGPLWAARRR LAQNALKSFS IASDPTLASS CYLEEHVSKE AEYLISKFQK 
LMAEVGHFDP FKYLVVSVAN VICAICFGRR YDHDDQELLS IVNLSNEFGE VTGSGYPADF 
IPILRYLPNS SLDAFKDLNK KFYSFMKKLI KEHYRTFEKG HIRDITDSLI EHCQDRRLDE 
NANVQLSDDK VITIVFDLFG AGFDTITTAI SWSLMYLVTN PRIQRKIQEE LDTVIGRDRQ 
PRLSDRPQLP YLEAFILETF RHSSFVPFTI PHSTIRDTSL NGFYIPKGHC VFVNQWQVNH 
DQELWGDPNE FRPERFLTSS GTLDKHLSEK VILFGLGKRK CIGETIGRLE VFLFLAILLQ 
QMEFNVSPGE KVDMTPAYGL TLKHARCEHF QVQMRSSGPQ HLQA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cyp1a1

Associated with

Other Information

Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 genes in the rat. PubMed ID: 6089174

Nucleotide sequence of a full-length cDNA coding for 3-methylcholanthrene-induced rat liver cytochrome P-450MC. PubMed ID: 6324135

Gene structure and nucleotide sequence for rat cytochrome P-450c. PubMed ID: 3838427

Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450. PubMed ID: 3718958

Effect of nutritional imbalances on cytochrome P-450 isozymes in rat liver. PubMed ID: 3041969

Identification and characterization of cytochrome P4501A1 amino acid residues interacting with a radiolabeled photoaffinity diazido-benzphetamine analogue. PubMed ID: 8651689

Targeting of NH2-terminal-processed microsomal protein to mitochondria: a novel pathway for the biogenesis of hepatic mitochondrial P450MT2. PubMed ID: 9348277

Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism. PubMed ID: 19401463

Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards. PubMed ID: 20972997

Discovery and confirmation of O-GlcNAcylated proteins in rat liver mitochondria by combination of mass spectrometry and immunological methods. PubMed ID: 24098488