Genular: Defining Cellular Identity and Function

Details for: Cyp1a2

Gene ID: 24297

Symbol: Cyp1a2

Ensembl ID: ENSRNOG00000016173

Description: cytochrome P450, family 1, subfamily a, polypeptide 2

Associated with

Aflatoxin activation and detoxification
(R-RNO-5423646)
Arachidonic acid metabolism
(R-RNO-2142753)
Aromatic amines can be n-hydroxylated or n-dealkylated by cyp1a2
(R-RNO-211957)
Biological oxidations
(R-RNO-211859)
Biosynthesis of dha-derived spms
(R-RNO-9018677)
Biosynthesis of maresin-like spms
(R-RNO-9027307)
Biosynthesis of maresins
(R-RNO-9018682)
Biosynthesis of protectins
(R-RNO-9018681)
Biosynthesis of specialized proresolving mediators (spms)
(R-RNO-9018678)
Cytochrome p450 - arranged by substrate type
(R-RNO-211897)
Fatty acid metabolism
(R-RNO-8978868)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Methylation
(R-RNO-156581)
Phase i - functionalization of compounds
(R-RNO-211945)
Phase ii - conjugation of compounds
(R-RNO-156580)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (hete)
(R-RNO-2142816)
Synthesis of epoxy (eet) and dihydroxyeicosatrienoic acids (dhet)
(R-RNO-2142670)
Xenobiotics
(R-RNO-211981)
Alkaloid metabolic process
(GO:0009820)
Arachidonic acid metabolic process
(GO:0019369)
Aromatase activity
(GO:0070330)
Caffeine oxidase activity
(GO:0034875)
Cellular aromatic compound metabolic process
(GO:0006725)
Cellular respiration
(GO:0045333)
Cellular response to cadmium ion
(GO:0071276)
Cellular response to copper ion
(GO:0071280)
Cholesterol metabolic process
(GO:0008203)
Demethylase activity
(GO:0032451)
Dibenzo-p-dioxin metabolic process
(GO:0018894)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Estrogen 2-hydroxylase activity
(GO:0101021)
Estrogen 16-alpha-hydroxylase activity
(GO:0101020)
Estrogen metabolic process
(GO:0008210)
Heme binding
(GO:0020037)
Heterocycle metabolic process
(GO:0046483)
Hydrogen peroxide biosynthetic process
(GO:0050665)
Hydroperoxy icosatetraenoate dehydratase activity
(GO:0106256)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Lung development
(GO:0030324)
Lyase activity
(GO:0016829)
Monocarboxylic acid metabolic process
(GO:0032787)
Monooxygenase activity
(GO:0004497)
Monoterpenoid metabolic process
(GO:0016098)
Nitrite reductase (no-forming) activity
(GO:0050421)
Nitroglycerin metabolic process
(GO:0018937)
Oxidative demethylation
(GO:0070989)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Porphyrin-containing compound metabolic process
(GO:0006778)
Post-embryonic development
(GO:0009791)
Regulation of gene expression
(GO:0010468)
Response to estradiol
(GO:0032355)
Response to immobilization stress
(GO:0035902)
Response to lipopolysaccharide
(GO:0032496)
Response to nitroglycerin
(GO:1904842)
Response to organic cyclic compound
(GO:0014070)
Response to organic substance
(GO:0010033)
Response to vitamin e
(GO:0033197)
Response to xenobiotic stimulus
(GO:0009410)
Retinol metabolic process
(GO:0042572)
Steroid catabolic process
(GO:0006706)
Toxin biosynthetic process
(GO:0009403)
Toxin metabolic process
(GO:0009404)
Vitamin e metabolic process
(GO:0042360)
Xenobiotic catabolic process
(GO:0042178)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

Cytochrome P450 1A2

Genular Protein ID: 932048576

Symbol: CP1A2_RAT

Name: Cytochrome P450 1A2

UniProtKB Accession Codes:

P04799 A1L120 Q64588

Database IDs:

Citations:

PubMed ID: 6584898

Title: Coding nucleotide sequence of 3-methylcholanthrene-inducible cytochrome P-450d cDNA from rat liver.

PubMed ID: 6584898

DOI: 10.1073/pnas.81.6.1649

PubMed ID: 2985574

Title: Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450 (P-450d) gene in the rat.

PubMed ID: 2985574

DOI: 10.1016/s0021-9258(18)89174-8

PubMed ID: 1793487

Title: Stable expression of rat cytochrome P450IA2 cDNA and hydroxylation of 17 beta-estradiol and 2-aminofluorene in V79 Chinese hamster cells.

PubMed ID: 1793487

DOI: 10.1002/mc.2940040613

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3947063

Title: The primary structure of cytochrome P-450d purified from rat liver microsomes: prediction of helical regions and domain analysis.

PubMed ID: 3947063

DOI: 10.1016/0003-9861(86)90121-9

PubMed ID: 3718958

Title: Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450.

PubMed ID: 3718958

DOI: 10.1021/bi00357a015

PubMed ID: 7074072

Title: Amino-terminal and carboxy-terminal sequence of hepatic microsomal cytochrome P-450d, a unique hemoprotein from rats treated with isosafrole.

PubMed ID: 7074072

DOI: 10.1021/bi00535a007

PubMed ID: 1420171

Title: Modification of cytochrome P450 1A2 enzymes by the mechanism-based inactivator 2-ethynylnaphthalene and the photoaffinity label 4-azidobiphenyl.

PubMed ID: 1420171

DOI: 10.1021/bi00158a019

PubMed ID: 6548743

Title: Characterization of complementary DNA clones coding for two forms of 3-methylcholanthrene-inducible rat liver cytochrome P-450.

PubMed ID: 6548743

DOI: 10.1093/oxfordjournals.jbchem.a134897

PubMed ID: 24098488

Title: Discovery and confirmation of O-GlcNAcylated proteins in rat liver mitochondria by combination of mass spectrometry and immunological methods.

PubMed ID: 24098488

DOI: 10.1371/journal.pone.0076399

Sequence Information:

Length: 513
Mass: 58259
Checksum: B1F06FDE9B7B6FA7
Sequence:

MAFSQYISLA PELLLATAIF CLVFWVLRGT RTQVPKGLKS PPGPWGLPFI GHMLTLGKNP 
HLSLTKLSQQ YGDVLQIRIG STPVVVLSGL NTIKQALVKQ GDDFKGRPDL YSFTLITNGK 
SMTFNPDSGP VWAARRRLAQ DALKSFSIAS DPTSVSSCYL EEHVSKEANH LISKFQKLMA 
EVGHFEPVNQ VVESVANVIG AMCFGKNFPR KSEEMLNLVK SSKDFVENVT SGNAVDFFPV 
LRYLPNPALK RFKNFNDNFV LFLQKTVQEH YQDFNKNSIQ DITGALFKHS ENYKDNGGLI 
PQEKIVNIVN DIFGAGFETV TTAIFWSILL LVTEPKVQRK IHEELDTVIG RDRQPRLSDR 
PQLPYLEAFI LEIYRYTSFV PFTIPHSTTR DTSLNGFHIP KECCIFINQW QVNHDEKQWK 
DPFVFRPERF LTNDNTAIDK TLSEKVMLFG LGKRRCIGEI PAKWEVFLFL AILLHQLEFT 
VPPGVKVDLT PSYGLTMKPR TCEHVQAWPR FSK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cyp1a2

Associated with

Other Information

Coding nucleotide sequence of 3-methylcholanthrene-inducible cytochrome P-450d cDNA from rat liver. PubMed ID: 6584898

Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450 (P-450d) gene in the rat. PubMed ID: 2985574

Stable expression of rat cytochrome P450IA2 cDNA and hydroxylation of 17 beta-estradiol and 2-aminofluorene in V79 Chinese hamster cells. PubMed ID: 1793487

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The primary structure of cytochrome P-450d purified from rat liver microsomes: prediction of helical regions and domain analysis. PubMed ID: 3947063

Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450. PubMed ID: 3718958

Amino-terminal and carboxy-terminal sequence of hepatic microsomal cytochrome P-450d, a unique hemoprotein from rats treated with isosafrole. PubMed ID: 7074072

Modification of cytochrome P450 1A2 enzymes by the mechanism-based inactivator 2-ethynylnaphthalene and the photoaffinity label 4-azidobiphenyl. PubMed ID: 1420171

Characterization of complementary DNA clones coding for two forms of 3-methylcholanthrene-inducible rat liver cytochrome P-450. PubMed ID: 6548743

Discovery and confirmation of O-GlcNAcylated proteins in rat liver mitochondria by combination of mass spectrometry and immunological methods. PubMed ID: 24098488