Details for: Cyp2d3

Gene ID: 24303

Symbol: Cyp2d3

Ensembl ID: ENSRNOG00000029179

Description: cytochrome P450, family 2, subfamily d, polypeptide 3

Associated with

  • Arachidonic acid metabolic process
    (GO:0019369)
  • Aromatase activity
    (GO:0070330)
  • Cytoplasm
    (GO:0005737)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Heme binding
    (GO:0020037)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Iron ion binding
    (GO:0005506)
  • Liver development
    (GO:0001889)
  • Monooxygenase activity
    (GO:0004497)
  • Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    (GO:0016712)
  • Xenobiotic metabolic process
    (GO:0006805)

Other Information

Genular Protein ID: 2846721544

Symbol: CP2D3_RAT

Name: Cytochrome P450 2D3

UniProtKB Accession Codes:

P12938 O35106 Q5FVU3

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BindingDB 1 CDD 1 CTD 1 ChEBI 10 ChEMBL 1 EC 2 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 1 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2819073

Title: The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats.

PubMed ID: 2819073

DOI: 10.1021/bi00444a030

PubMed ID: 2107330

Title: The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site.

PubMed ID: 2107330

DOI: 10.1007/bf02099942

PubMed ID: 9434752

Title: Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity.

PubMed ID: 9434752

DOI: 10.1006/abbi.1997.0402

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 500
  • Mass: 56642
  • Checksum: C54727C2C00F73F6
  • Sequence:
    • MELLAGTGLW PMAIFTVIFI LLVDLMHRRQ RWTSRYPPGP VPWPVLGNLL QVDLCNMPYS 
MYKLQNRYGD VFSLQMGWKP VVVINGLKAV QELLVTCGED TADRPEMPIF QHIGYGHKAK 
GVVLAPYGPE WREQRRFSVS TLRNFGVGKK SLEQWVTDEA SHLCDALTAE AGRPLDPYTL 
LNKAVCNVIA SLIYARRFDY GDPDFIKVLK ILKESMGEQT GLFPEVLNMF PVLLRIPGLA 
DKVFPGQKTF LTMVDNLVTE HKKTWDPDQP PRDLTDAFLA EIEKAKGNPE SSFNDANLRL 
VVNDLFGAGM VTTSITLTWA LLLMILHPDV QCRVQQEIDE VIGQVRHPEM ADQAHMPFTN 
AVIHEVQRFA DIVPMNLPHK TSRDIEVQGF LIPKGTTLIP NLSSVLKDET VWEKPLRFHP 
EHFLDAQGNF VKHEAFMPFS AGRRACLGEP LARMELFLFF TCLLQRFSFS VPTGQPRPSD 
YGVFAFLLSP SPYQLCAFKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.