Genular: Defining Cellular Identity and Function

Details for: Cyp4a2

Gene ID: 24306

Symbol: Cyp4a2

Ensembl ID: ENSRNOG00000066487

Description: cytochrome P450, family 4, subfamily a, polypeptide 2

Associated with

Arachidonic acid metabolism
(R-RNO-2142753)
Biological oxidations
(R-RNO-211859)
Cytochrome p450 - arranged by substrate type
(R-RNO-211897)
Eicosanoids
(R-RNO-211979)
Fatty acid metabolism
(R-RNO-8978868)
Fatty acids
(R-RNO-211935)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Miscellaneous substrates
(R-RNO-211958)
Phase i - functionalization of compounds
(R-RNO-211945)
Synthesis of leukotrienes (lt) and eoxins (ex)
(R-RNO-2142691)
Alkane 1-monooxygenase activity
(GO:0018685)
Arachidonic acid 11,12-epoxygenase activity
(GO:0008405)
Arachidonic acid binding
(GO:0050544)
Arachidonic acid metabolic process
(GO:0019369)
Arachidonic acid monooxygenase activity
(GO:0008391)
Endoplasmic reticulum membrane
(GO:0005789)
Fatty acid binding
(GO:0005504)
Heme binding
(GO:0020037)
Icosanoid biosynthetic process
(GO:0046456)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Kidney development
(GO:0001822)
Lauric acid metabolic process
(GO:0048252)
Linoleic acid metabolic process
(GO:0043651)
Long-chain fatty acid omega-hydroxylase activity
(GO:0102033)
Membrane
(GO:0016020)
Monooxygenase activity
(GO:0004497)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
(GO:0016705)
Response to hormone
(GO:0009725)
Response to xenobiotic stimulus
(GO:0009410)

Other Information

Proteins

Cytochrome P450 4A2

Genular Protein ID: 4192703113

Symbol: CP4A2_RAT

Name: Cytochrome P450 4A2

UniProtKB Accession Codes:

P20816 Q4G071

Database IDs:

Citations:

PubMed ID: 2766932

Title: The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element.

PubMed ID: 2766932

DOI: 10.1089/dna.1.1989.8.503

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1739747

Title: Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid omega-hydroxylases.

PubMed ID: 1739747

DOI: 10.1016/0005-2760(92)90106-6

PubMed ID: 2306108

Title: Characterization of three cytochrome P450s purified from renal microsomes of untreated male rats and comparison with human renal cytochrome P450.

PubMed ID: 2306108

DOI: 10.1016/0003-9861(90)90747-m

PubMed ID: 10620324

Title: Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases.

PubMed ID: 10620324

DOI: 10.1006/abbi.1999.1504

PubMed ID: 10869363

Title: Molecular basis for the omega-regiospecificity of the CYP4A2 and CYP4A3 fatty acid hydroxylases.

PubMed ID: 10869363

DOI: 10.1074/jbc.m004841200

PubMed ID: 11139583

Title: Covalently linked heme in cytochrome P4504A fatty acid hydroxylases.

PubMed ID: 11139583

DOI: 10.1074/jbc.m009969200

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 504
Mass: 57969
Checksum: 8A795DD454125287
Sequence:

MGFSVFSPTR SLDGVSGFFQ GAFLLSLFLV LFKAVQFYLR RQWLLKALEK FPSTPSHWLW 
GHNLKDREFQ QVLTWVEKFP GACLQWLSGS TARVLLYDPD YVKVVLGRSD PKPYQSLAPW 
IGYGLLLLNG KKWFQHRRML TPAFHYDILK PYVKIMADSV SIMLDKWEKL DDQDHPLEIF 
HYVSLMTLDT VMKCAFSHQG SVQLDVNSRS YTKAVEDLNN LIFFRVRSAF YGNSIIYNMS 
SDGRLSRRAC QIAHEHTDGV IKTRKAQLQN EEELQKARKK RHLDFLDILL FAKMEDGKSL 
SDEDLRAEVD TFMFEGHDTT ASGISWVFYA LATHPEHQER CREEVQSILG DGTSVTWDHL 
DQMPYTTMCI KEALRLYSPV PSVSRELSSP VTFPDGRSIP KGIRVTILIY GLHHNPSYWP 
NPKVFDPSRF SPDSPRHSHA YLPFSGGARN CIGKQFAMNE LKVAVALTLL RFELLPDPTR 
IPVPMPRLVL KSKNGIHLRL KKLR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cyp4a2

Associated with

Other Information

The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element. PubMed ID: 2766932

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid omega-hydroxylases. PubMed ID: 1739747

Characterization of three cytochrome P450s purified from renal microsomes of untreated male rats and comparison with human renal cytochrome P450. PubMed ID: 2306108

Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases. PubMed ID: 10620324

Molecular basis for the omega-regiospecificity of the CYP4A2 and CYP4A3 fatty acid hydroxylases. PubMed ID: 10869363

Covalently linked heme in cytochrome P4504A fatty acid hydroxylases. PubMed ID: 11139583

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903