Genular: Defining Cellular Identity and Function

Details for: Ace

Gene ID: 24310

Symbol: Ace

Ensembl ID: ENSRNOG00000062101

Description: angiotensin I converting enzyme

Associated with

Metabolism of angiotensinogen to angiotensins
(R-RNO-2022377)
Metabolism of proteins
(R-RNO-392499)
Peptide hormone metabolism
(R-RNO-2980736)
Actin binding
(GO:0003779)
Amyloid-beta metabolic process
(GO:0050435)
Angiogenesis involved in coronary vascular morphogenesis
(GO:0060978)
Angiotensin-activated signaling pathway
(GO:0038166)
Angiotensin maturation
(GO:0002003)
Animal organ regeneration
(GO:0031100)
Arachidonic acid secretion
(GO:0050482)
Basal plasma membrane
(GO:0009925)
Bradykinin catabolic process
(GO:0010815)
Bradykinin receptor binding
(GO:0031711)
Brush border membrane
(GO:0031526)
Calmodulin binding
(GO:0005516)
Carboxypeptidase activity
(GO:0004180)
Cell proliferation in bone marrow
(GO:0071838)
Cellular response to aldosterone
(GO:1904045)
Cellular response to glucose stimulus
(GO:0071333)
Chloride ion binding
(GO:0031404)
Cytoplasm
(GO:0005737)
Eating behavior
(GO:0042755)
Embryo development ending in birth or egg hatching
(GO:0009792)
Endopeptidase activity
(GO:0004175)
Endosome
(GO:0005768)
Exopeptidase activity
(GO:0008238)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Female pregnancy
(GO:0007565)
Heart contraction
(GO:0060047)
Heterocyclic compound binding
(GO:1901363)
Hormone catabolic process
(GO:0042447)
Hormone metabolic process
(GO:0042445)
Kidney development
(GO:0001822)
Lung alveolus development
(GO:0048286)
Lung development
(GO:0030324)
Lysosome
(GO:0005764)
Male gonad development
(GO:0008584)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Metallodipeptidase activity
(GO:0070573)
Metalloendopeptidase activity
(GO:0004222)
Metallopeptidase activity
(GO:0008237)
Mitogen-activated protein kinase binding
(GO:0051019)
Mitogen-activated protein kinase kinase binding
(GO:0031434)
Negative regulation of calcium ion import
(GO:0090281)
Negative regulation of gap junction assembly
(GO:1903597)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of glucose import
(GO:0046325)
Neutrophil mediated immunity
(GO:0002446)
Peptidase activity
(GO:0008233)
Peptide catabolic process
(GO:0043171)
Peptide metabolic process
(GO:0006518)
Peptidyl-dipeptidase activity
(GO:0008241)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of blood pressure
(GO:0045777)
Positive regulation of neurogenesis
(GO:0050769)
Positive regulation of peptidyl-cysteine s-nitrosylation
(GO:2000170)
Positive regulation of systemic arterial blood pressure
(GO:0003084)
Positive regulation of vasoconstriction
(GO:0045907)
Post-transcriptional regulation of gene expression
(GO:0010608)
Proteolysis
(GO:0006508)
Regulation of angiotensin metabolic process
(GO:0060177)
Regulation of blood pressure
(GO:0008217)
Regulation of heart rate by cardiac conduction
(GO:0086091)
Regulation of hematopoietic stem cell proliferation
(GO:1902033)
Regulation of smooth muscle cell migration
(GO:0014910)
Regulation of synaptic plasticity
(GO:0048167)
Regulation of systemic arterial blood pressure by renin-angiotensin
(GO:0003081)
Response to dexamethasone
(GO:0071548)
Response to hypoxia
(GO:0001666)
Response to laminar fluid shear stress
(GO:0034616)
Response to lipopolysaccharide
(GO:0032496)
Response to nutrient levels
(GO:0031667)
Response to thyroid hormone
(GO:0097066)
Response to xenobiotic stimulus
(GO:0009410)
Spermatogenesis
(GO:0007283)
Sperm midpiece
(GO:0097225)
Substance p catabolic process
(GO:0010814)
Tripeptidyl-peptidase activity
(GO:0008240)
Vasoconstriction
(GO:0042310)
Vesicle
(GO:0031982)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Dipeptidyl carboxypeptidase I

Genular Protein ID: 1756637643

Symbol: ACE_RAT

Name: Dipeptidyl carboxypeptidase I

UniProtKB Accession Codes:

P47820 Q7TMC6 Q8CFN1 Q9EQM9

Database IDs:

Citations:

PubMed ID: 8292044

Title: Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme.

PubMed ID: 8292044

DOI: 10.1006/bbrc.1994.1053

PubMed ID: 12963491

Title: Species-specific splicing and expression of angiotensin converting enzyme.

PubMed ID: 12963491

DOI: 10.1016/s0006-2952(03)00457-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20487892

Title: Separate metabolic pathways for Leu-enkephalin and Met-enkephalin-Arg(6)-Phe(7) degradation by rat striatal synaptosomal membranes.

PubMed ID: 20487892

DOI: 10.1016/0197-0186(82)90081-x

PubMed ID: 12500972

Title: Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme.

PubMed ID: 12500972

DOI: 10.1074/jbc.m212030200

PubMed ID: 15671045

Title: Myocardial infarction increases ACE2 expression in rat and humans.

PubMed ID: 15671045

DOI: 10.1093/eurheartj/ehi114

PubMed ID: 18077343

Title: Hemopressin is an inverse agonist of CB1 cannabinoid receptors.

PubMed ID: 18077343

DOI: 10.1073/pnas.0706980105

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 1313
Mass: 150908
Checksum: 8CB5D0015F129591
Sequence:

MGAASGQRGR WPLSPPLLML SLLLLLLLPP SPAPALDPGL QPGNFSADEA GAQLFADSYN 
SSAEVVMFQS TAASWAHDTN ITEENARLQE EAALINQEFA EVWGKKAKEL YESIWQNFTD 
QKLRRIIGSV QTLGPANLPL TQRLQYNSLL SNMSRIYSTG KVCFPNKTAT CWSLDPELTN 
ILASSRNYAK VLFAWEGWHD AVGIPLRPLY QDFTALSNEA YRQDGFSDTG AYWRSWYESP 
SFEESLEHLY HQVEPLYLNL HAFVRRALHR RYGDKYINLR GPIPAHLLGD MWAQSWENIY 
DMVVPFPDKP NLDVTSTMVQ KGWNATHMFR VAEEFFTSLG LSPMPPEFWA ESMLEKPADG 
REVVCHASAW DFYNRKDFRI KQCTRVTMDQ LSTVHHEMGH VQYYLQYKDL HVSLRRGANP 
GFHEAIGDVL ALSVSTPAHL HKIGLLDRVA NDIESDINYL LKMALEKIAF LPFGYLVDQW 
RWGVFSGRTP PSRYNYDWWY LRTKYQGICP PVARNETHFD AGAKFHIPSV TPYIRYFVSF 
VLQFQFHQAL CKEAGHQGPL HQCDIYQSTK AGAKLQQVLQ AGCSRPWQEV LKDLVGSDAL 
DASALMEYFQ PVSQWLQEQN QRNGEVLGWP EYQWRPPLPD NYPEGIDLET DEAKANRFVE 
EYDRTAKVLW NEYAEANWHY NTNITIEGSK ILLQKNKEVS NHTLKYGTWA KTFDVSNFQN 
STIKRIIKKV QNVDRAVLPP NELEEYNQIL LDMETTYSVA NVCYTNGTCL SLEPDLTNIM 
ATSRKYEELL WVWKSWRDKV GRAILPFFPK YVDFSNKIAK LNGYSDAGDS WRSSYESDDL 
EQDLEKLYQE LQPLYLNLHA YVRRSLHRHY GSEYINLDGP IPAHLLGNMW AQTWSNIYDL 
VAPFPSAPSI DATEAMIKQG WTPRRIFKEA DNFFTSLGLL PVPPEFWNKS MLEKPTDGRE 
VVCHASAWDF YNGKDFRIKQ CTSVNMEELV IAHHEMGHIQ YFMQYKDLPV TFREGANPGF 
HEAIGDVLAL SVSTPKHLHS LNLLSSEGSG YEHDINFLMK MALDKIAFIP FSYLIDQWRW 
RVFDGSITKE NYNQEWWSLR LKYQGLCPPV PRSQGDFDPG SKFHVPANVP YIRYFISFII 
QFQFHEALCR AAGHTGPLYK CDIYQSKEAG KLLADAMKLG YSKQWPEAMK IITGQPNMSA 
SAIMNYFKPL TEWLVTENRR HGETLGWPEY TWTPNTARAE GSLPESSRVN FLGMYLEPQQ 
ARVGQWVLLF LGVALLVATV GLAHRLYNIH NHHSLRRPHR GPQFGSEVEL RHS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ace

Associated with

Other Information

Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme. PubMed ID: 8292044

Species-specific splicing and expression of angiotensin converting enzyme. PubMed ID: 12963491

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Separate metabolic pathways for Leu-enkephalin and Met-enkephalin-Arg(6)-Phe(7) degradation by rat striatal synaptosomal membranes. PubMed ID: 20487892

Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. PubMed ID: 12500972

Myocardial infarction increases ACE2 expression in rat and humans. PubMed ID: 15671045

Hemopressin is an inverse agonist of CB1 cannabinoid receptors. PubMed ID: 18077343

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903