Genular: Defining Cellular Identity and Function

Details for: Dhfr

Gene ID: 24312

Symbol: Dhfr

Ensembl ID: ENSRNOG00000013521

Description: dihydrofolate reductase

Associated with

Metabolism
(R-RNO-1430728)
Metabolism of folate and pterines
(R-RNO-196757)
Metabolism of vitamins and cofactors
(R-RNO-196854)
Metabolism of water-soluble vitamins and cofactors
(R-RNO-196849)
Axon regeneration
(GO:0031103)
Cytoplasm
(GO:0005737)
Dihydrofolate metabolic process
(GO:0046452)
Dihydrofolate reductase activity
(GO:0004146)
Dihydrofolic acid binding
(GO:0051871)
Folic acid binding
(GO:0005542)
Folic acid metabolic process
(GO:0046655)
Glycine biosynthetic process
(GO:0006545)
Mitochondrion
(GO:0005739)
Mrna binding
(GO:0003729)
Mrna regulatory element binding translation repressor activity
(GO:0000900)
Nadp binding
(GO:0050661)
Nadph binding
(GO:0070402)
Negative regulation of translation
(GO:0017148)
Nucleus
(GO:0005634)
Regulation of removal of superoxide radicals
(GO:2000121)
Response to methotrexate
(GO:0031427)
Response to nicotine
(GO:0035094)
Sequence-specific mrna binding
(GO:1990825)
Tetrahydrobiopterin biosynthetic process
(GO:0006729)
Tetrahydrofolate biosynthetic process
(GO:0046654)
Tetrahydrofolate interconversion
(GO:0035999)
Tetrahydrofolate metabolic process
(GO:0046653)

Other Information

Proteins

Dihydrofolate reductase

Genular Protein ID: 299438959

Symbol: DYR_RAT

Name: Dihydrofolate reductase

UniProtKB Accession Codes:

Q920D2

Database IDs:

Citations:

PubMed ID: 11502523

Title: Isolation of rat dihydrofolate reductase gene and characterization of recombinant enzyme.

PubMed ID: 11502523

DOI: 10.1128/aac.45.9.2517-2523.2001

PubMed ID: 25980602

Title: An active second dihydrofolate reductase enzyme is not a feature of rat and mouse, but they do have activity in their mitochondria.

PubMed ID: 25980602

DOI: 10.1016/j.febslet.2015.05.017

Sequence Information:

Length: 187
Mass: 21638
Checksum: FE1DB4F3515F8B26
Sequence:

MVRPLNCIVA VSQNMGIGKN GDLPWPLLRN EFKYFQRMTT TSSVEGKQNL VIMGRKTWFS 
IPEKNRPLKD RINIVLSREL KEPPQGAHFL AKSLDDALKL IEQPELASKV DMVWVVGGSS 
VYQEAMNQPG HLRLFVTRIM QEFESDTFFP EIDLEKYKLL PEYPGVLSEI QEEKGIKYKF 
EVYEKKD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.