Genular: Defining Cellular Identity and Function

Details for: Nqo1

Gene ID: 24314

Symbol: Nqo1

Ensembl ID: ENSRNOG00000012772

Description: NAD(P)H quinone dehydrogenase 1

Associated with

Metabolism
(R-RNO-1430728)
Metabolism of amino acids and derivatives
(R-RNO-71291)
Metabolism of polyamines
(R-RNO-351202)
Regulation of ornithine decarboxylase (odc)
(R-RNO-350562)
Cell redox homeostasis
(GO:0045454)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to metal ion
(GO:0071248)
Cellular response to oxidative stress
(GO:0034599)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Nad(p)h dehydrogenase (quinone) activity
(GO:0003955)
Nadh dehydrogenase (quinone) activity
(GO:0050136)
Nadh oxidation
(GO:0006116)
Nadph dehydrogenase (quinone) activity
(GO:0008753)
Nadph oxidation
(GO:0070995)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of protein catabolic process
(GO:0042177)
Neuronal cell body
(GO:0043025)
Nucleus
(GO:0005634)
Positive regulation of neuron apoptotic process
(GO:0043525)
Protein catabolic process
(GO:0030163)
Protein polyubiquitination
(GO:0000209)
Removal of superoxide radicals
(GO:0019430)
Response to alkaloid
(GO:0043279)
Response to amine
(GO:0014075)
Response to carbohydrate
(GO:0009743)
Response to electrical stimulus
(GO:0051602)
Response to estradiol
(GO:0032355)
Response to ethanol
(GO:0045471)
Response to flavonoid
(GO:1905395)
Response to hormone
(GO:0009725)
Response to hydrogen sulfide
(GO:1904880)
Response to ischemia
(GO:0002931)
Response to l-glutamine
(GO:1904844)
Response to lipopolysaccharide
(GO:0032496)
Response to nitrogen compound
(GO:1901698)
Response to nutrient
(GO:0007584)
Response to organic cyclic compound
(GO:0014070)
Response to organic substance
(GO:0010033)
Response to oxidative stress
(GO:0006979)
Response to testosterone
(GO:0033574)
Response to tetrachloromethane
(GO:1904772)
Response to xenobiotic stimulus
(GO:0009410)
Superoxide dismutase activity
(GO:0004784)
Superoxide metabolic process
(GO:0006801)
Ubiquinone metabolic process
(GO:0006743)
Vitamin e metabolic process
(GO:0042360)
Vitamin k metabolic process
(GO:0042373)

Other Information

Proteins

NAD(P)H dehydrogenase [quinone] 1

Genular Protein ID: 1020355809

Symbol: NQO1_RAT

Name: NAD(P)H dehydrogenase [quinone] 1

UniProtKB Accession Codes:

P05982 Q63478

Database IDs:

Citations:

PubMed ID: 3536915

Title: NAD(P)H:menadione oxidoreductase. Novel purification of enzyme cDNA and complete amino acid sequence, and gene regulation.

PubMed ID: 3536915

DOI: 10.1016/s0021-9258(18)66789-4

PubMed ID: 3100515

Title: Rat liver NAD(P)H: quinone reductase nucleotide sequence analysis of a quinone reductase cDNA clone and prediction of the amino acid sequence of the corresponding protein.

PubMed ID: 3100515

DOI: 10.1016/s0021-9258(19)75821-9

PubMed ID: 2480957

Title: Rat liver NAD(P)H:quinone reductase. Regulation of quinone reductase gene expression by planar aromatic compounds and determination of the exon structure of the quinone reductase structural gene.

PubMed ID: 2480957

DOI: 10.1016/s0021-9258(20)88253-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3143406

Title: Structure-function relationship of NAD(P)H:quinone reductase: characterization of NH2-terminal blocking group and essential tyrosine and lysine residues.

PubMed ID: 3143406

DOI: 10.1021/bi00418a033

PubMed ID: 2963593

Title: Rat liver NAD(P)H:quinone reductase: isolation of a quinone reductase structural gene and prediction of the NH2 terminal sequence of the protein by double-stranded sequencing of exons 1 and 2.

PubMed ID: 2963593

DOI: 10.1016/0003-9861(88)90516-4

PubMed ID: 1703398

Title: Expression of mammalian DT-diaphorase in Escherichia coli: purification and characterization of the expressed protein.

PubMed ID: 1703398

DOI: 10.1016/0003-9861(90)90648-i

PubMed ID: 3144286

Title: The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2).

PubMed ID: 3144286

DOI: 10.1016/0006-2952(88)90336-x

PubMed ID: 2504488

Title: Transcriptional down-regulation of a rat gene, WDNM2, in metastatic DMBA-8 cells.

PubMed ID: 2504488

PubMed ID: 2499768

Title: Reaction of rat liver DT-diaphorase (NAD(P)H:quinone acceptor reductase) with 5'-[p-(fluorosulfonyl)benzoyl]-adenosine.

PubMed ID: 2499768

PubMed ID: 2141979

Title: Rat liver NAD(P)H:quinone oxidoreductase: cDNA expression and site-directed mutagenesis.

PubMed ID: 2141979

DOI: 10.1016/0006-291x(90)92006-l

PubMed ID: 7862630

Title: Subunit functional studies of NAD(P)H:quinone oxidoreductase with a heterodimer approach.

PubMed ID: 7862630

DOI: 10.1073/pnas.92.4.1043

PubMed ID: 8999809

Title: Molecular basis of the catalytic differences among DT-diaphorase of human, rat, and mouse.

PubMed ID: 8999809

DOI: 10.1074/jbc.272.3.1437

PubMed ID: 7568029

Title: The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction.

PubMed ID: 7568029

DOI: 10.1073/pnas.92.19.8846

Sequence Information:

Length: 274
Mass: 30947
Checksum: 40E8801320A20F09
Sequence:

MAVRRALIVL AHAERTSFNY AMKEAAVEAL KKKGWEVVES DLYAMNFNPL ISRNDITGEP 
KDSENFQYPV ESSLAYKEGR LSPDIVAEQK KLEAADLVIF QFPLYWFGVP AILKGWFERV 
LVAGFAYTYA TMYDKGPFQN KKTLLSITTG GSGSMYSLQG VHGDMNVILW PIQSGILRFC 
GFQVLEPQLV YSIGHTPPDA RVQVLEGWKK RLETVWEESP LYFAPSSLFD LNFQAGFLLK 
KEVQEEQKKN KFGLSVGHHL GKSIPADNQI KARK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nqo1

Associated with

Other Information

NAD(P)H:menadione oxidoreductase. Novel purification of enzyme cDNA and complete amino acid sequence, and gene regulation. PubMed ID: 3536915

Rat liver NAD(P)H: quinone reductase nucleotide sequence analysis of a quinone reductase cDNA clone and prediction of the amino acid sequence of the corresponding protein. PubMed ID: 3100515

Rat liver NAD(P)H:quinone reductase. Regulation of quinone reductase gene expression by planar aromatic compounds and determination of the exon structure of the quinone reductase structural gene. PubMed ID: 2480957

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure-function relationship of NAD(P)H:quinone reductase: characterization of NH2-terminal blocking group and essential tyrosine and lysine residues. PubMed ID: 3143406

Rat liver NAD(P)H:quinone reductase: isolation of a quinone reductase structural gene and prediction of the NH2 terminal sequence of the protein by double-stranded sequencing of exons 1 and 2. PubMed ID: 2963593

Expression of mammalian DT-diaphorase in Escherichia coli: purification and characterization of the expressed protein. PubMed ID: 1703398

The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2). PubMed ID: 3144286

Transcriptional down-regulation of a rat gene, WDNM2, in metastatic DMBA-8 cells. PubMed ID: 2504488

Reaction of rat liver DT-diaphorase (NAD(P)H:quinone acceptor reductase) with 5'-[p-(fluorosulfonyl)benzoyl]-adenosine. PubMed ID: 2499768

Rat liver NAD(P)H:quinone oxidoreductase: cDNA expression and site-directed mutagenesis. PubMed ID: 2141979

Subunit functional studies of NAD(P)H:quinone oxidoreductase with a heterodimer approach. PubMed ID: 7862630

Molecular basis of the catalytic differences among DT-diaphorase of human, rat, and mouse. PubMed ID: 8999809

The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction. PubMed ID: 7568029