Genular: Defining Cellular Identity and Function

Details for: Drd2

Gene ID: 24318

Symbol: Drd2

Ensembl ID: ENSRNOG00000008428

Description: dopamine receptor D2

Associated with

Amine ligand-binding receptors
(R-RNO-375280)
Class a/1 (rhodopsin-like receptors)
(R-RNO-373076)
Dopamine receptors
(R-RNO-390651)
Gpcr ligand binding
(R-RNO-500792)
Signaling by gpcr
(R-RNO-372790)
Signal transduction
(R-RNO-162582)
Adenohypophysis development
(GO:0021984)
Adenylate cyclase-inhibiting dopamine receptor signaling pathway
(GO:0007195)
Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
(GO:0007188)
Adult behavior
(GO:0030534)
Adult walking behavior
(GO:0007628)
Associative learning
(GO:0008306)
Auditory behavior
(GO:0031223)
Autophagy
(GO:0006914)
Axonogenesis
(GO:0007409)
Cell migration
(GO:0016477)
Cell population proliferation
(GO:0008283)
Cerebral cortex gabaergic interneuron migration
(GO:0021853)
Circadian regulation of gene expression
(GO:0032922)
Dopamine binding
(GO:0035240)
Dopamine metabolic process
(GO:0042417)
Dopamine neurotransmitter receptor activity
(GO:0004952)
Dopamine neurotransmitter receptor activity, coupled via gi/go
(GO:0001591)
Dopamine receptor signaling pathway
(GO:0007212)
Drinking behavior
(GO:0042756)
Feeding behavior
(GO:0007631)
Forebrain development
(GO:0030900)
G-protein alpha-subunit binding
(GO:0001965)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor internalization
(GO:0002031)
G protein-coupled receptor signaling pathway
(GO:0007186)
Grooming behavior
(GO:0007625)
Heterocyclic compound binding
(GO:1901363)
Heterotrimeric g-protein binding
(GO:0032795)
Identical protein binding
(GO:0042802)
Intracellular potassium ion homeostasis
(GO:0030007)
Intracellular signal transduction
(GO:0035556)
Ionotropic glutamate receptor binding
(GO:0035255)
Locomotory behavior
(GO:0007626)
Long-term memory
(GO:0007616)
Negative regulation of adenylate cyclase activity
(GO:0007194)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of circadian sleep/wake cycle, sleep
(GO:0042321)
Negative regulation of dopamine secretion
(GO:0033602)
Negative regulation of protein phosphorylation
(GO:0001933)
Nervous system process involved in regulation of systemic arterial blood pressure
(GO:0001976)
Neuroblast proliferation
(GO:0007405)
Neuron-neuron synaptic transmission
(GO:0007270)
Neuron migration
(GO:0001764)
Orbitofrontal cortex development
(GO:0021769)
Organic cyclic compound binding
(GO:0097159)
Peristalsis
(GO:0030432)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Pigmentation
(GO:0043473)
Positive regulation of cytokinesis
(GO:0032467)
Positive regulation of multicellular organism growth
(GO:0040018)
Positive regulation of neuroblast proliferation
(GO:0002052)
Positive regulation of receptor internalization
(GO:0002092)
Positive regulation of renal sodium excretion
(GO:0035815)
Positive regulation of urine volume
(GO:0035810)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein localization
(GO:0008104)
Regulation of dopamine secretion
(GO:0014059)
Regulation of heart rate
(GO:0002027)
Regulation of mapk cascade
(GO:0043408)
Regulation of potassium ion transport
(GO:0043266)
Regulation of sodium ion transport
(GO:0002028)
Regulation of synaptic transmission, gabaergic
(GO:0032228)
Response to amphetamine
(GO:0001975)
Response to cocaine
(GO:0042220)
Response to ethanol
(GO:0045471)
Response to histamine
(GO:0034776)
Response to hypoxia
(GO:0001666)
Response to inactivity
(GO:0014854)
Response to iron ion
(GO:0010039)
Response to light stimulus
(GO:0009416)
Response to morphine
(GO:0043278)
Response to nicotine
(GO:0035094)
Response to toxic substance
(GO:0009636)
Response to xenobiotic stimulus
(GO:0009410)
Sensory perception of smell
(GO:0007608)
Signaling receptor binding
(GO:0005102)
Startle response
(GO:0001964)
Striatum development
(GO:0021756)
Synapse assembly
(GO:0007416)
Temperature homeostasis
(GO:0001659)
Visual learning
(GO:0008542)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

D(2) dopamine receptor

Genular Protein ID: 2249932961

Symbol: DRD2_RAT

Name: D(2) dopamine receptor

UniProtKB Accession Codes:

P61169 P13953

Database IDs:

Citations:

PubMed ID: 2974511

Title: Cloning and expression of a rat D2 dopamine receptor cDNA.

PubMed ID: 2974511

DOI: 10.1038/336783a0

PubMed ID: 2531656

Title: The dopamine D2 receptor: two molecular forms generated by alternative splicing.

PubMed ID: 2531656

DOI: 10.1002/j.1460-2075.1989.tb08585.x

PubMed ID: 2531846

Title: D2 receptor, a missing exon.

PubMed ID: 2531846

DOI: 10.1038/342865a0

PubMed ID: 2531847

Title: Alternative splicing directs the expression of two D2 dopamine receptor isoforms.

PubMed ID: 2531847

DOI: 10.1038/342923a0

PubMed ID: 2480527

Title: Multiple D2 dopamine receptors produced by alternative RNA splicing.

PubMed ID: 2480527

DOI: 10.1038/342926a0

PubMed ID: 2139615

Title: Two forms of the rat D2 dopamine receptor as revealed by the polymerase chain reaction.

PubMed ID: 2139615

DOI: 10.1016/0014-5793(90)80695-f

PubMed ID: 2137336

Title: Identification by sequence analysis of a second rat brain cDNA encoding the dopamine (D2) receptor.

PubMed ID: 2137336

DOI: 10.1016/0006-291x(90)91917-h

PubMed ID: 2138567

Title: Cloning of two additional catecholamine receptors from rat brain.

PubMed ID: 2138567

DOI: 10.1016/0014-5793(90)80140-e

PubMed ID: 2137198

Title: A second molecular form of D2 dopamine receptor in rat and bovine caudate nucleus.

PubMed ID: 2137198

DOI: 10.1038/343266a0

PubMed ID: 1321233

Title: Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors.

PubMed ID: 1321233

DOI: 10.1111/j.1471-4159.1992.tb09416.x

PubMed ID: 10391935

Title: Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein.

PubMed ID: 10391935

DOI: 10.1074/jbc.274.28.19894

PubMed ID: 14499480

Title: CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors.

PubMed ID: 14499480

DOI: 10.1016/s0169-328x(03)00283-3

PubMed ID: 16049099

Title: Dopamine responsiveness is regulated by targeted sorting of D2 receptors.

PubMed ID: 16049099

DOI: 10.1073/pnas.0502418102

PubMed ID: 19332542

Title: G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor.

PubMed ID: 19332542

DOI: 10.1074/jbc.m900388200

PubMed ID: 1358063

Title: Molecular modelling of D2-like dopamine receptors.

PubMed ID: 1358063

DOI: 10.1042/bj2870277

Sequence Information:

Length: 444
Mass: 50904
Checksum: 216E56CEE5CA32FB
Sequence:

MDPLNLSWYD DDLERQNWSR PFNGSEGKAD RPHYNYYAML LTLLIFIIVF GNVLVCMAVS 
REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW KFSRIHCDIF VTLDVMMCTA 
SILNLCAISI DRYTAVAMPM LYNTRYSSKR RVTVMIAIVW VLSFTISCPL LFGLNNTDQN 
ECIIANPAFV VYSSIVSFYV PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL 
KGNCTHPEDM KLCTVIMKSN GSFPVNRRRM DAARRAQELE MEMLSSTSPP ERTRYSPIPP 
SHHQLTLPDP SHHGLHSNPD SPAKPEKNGH AKIVNPRIAK FFEIQTMPNG KTRTSLKTMS 
RRKLSQQKEK KATQMLAIVL GVFIICWLPF FITHILNIHC DCNIPPVLYS AFTWLGYVNS 
AVNPIIYTTF NIEFRKAFMK ILHC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Drd2

Associated with

Other Information

Cloning and expression of a rat D2 dopamine receptor cDNA. PubMed ID: 2974511

The dopamine D2 receptor: two molecular forms generated by alternative splicing. PubMed ID: 2531656

D2 receptor, a missing exon. PubMed ID: 2531846

Alternative splicing directs the expression of two D2 dopamine receptor isoforms. PubMed ID: 2531847

Multiple D2 dopamine receptors produced by alternative RNA splicing. PubMed ID: 2480527

Two forms of the rat D2 dopamine receptor as revealed by the polymerase chain reaction. PubMed ID: 2139615

Identification by sequence analysis of a second rat brain cDNA encoding the dopamine (D2) receptor. PubMed ID: 2137336

Cloning of two additional catecholamine receptors from rat brain. PubMed ID: 2138567

A second molecular form of D2 dopamine receptor in rat and bovine caudate nucleus. PubMed ID: 2137198

Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors. PubMed ID: 1321233

Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein. PubMed ID: 10391935

CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. PubMed ID: 14499480

Dopamine responsiveness is regulated by targeted sorting of D2 receptors. PubMed ID: 16049099

G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor. PubMed ID: 19332542

Molecular modelling of D2-like dopamine receptors. PubMed ID: 1358063