Genular: Defining Cellular Identity and Function

Details for: Edn1

Gene ID: 24323

Symbol: Edn1

Ensembl ID: ENSRNOG00000014361

Description: endothelin 1

Associated with

Class a/1 (rhodopsin-like receptors)
(R-RNO-373076)
G alpha (q) signalling events
(R-RNO-416476)
Gpcr downstream signalling
(R-RNO-388396)
Gpcr ligand binding
(R-RNO-500792)
Peptide ligand-binding receptors
(R-RNO-375276)
Signaling by gpcr
(R-RNO-372790)
Signal transduction
(R-RNO-162582)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Artery smooth muscle contraction
(GO:0014824)
Axon guidance
(GO:0007411)
Body fluid secretion
(GO:0007589)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Calcium-mediated signaling
(GO:0019722)
Cardiac neural crest cell migration involved in outflow tract morphogenesis
(GO:0003253)
Cell-cell signaling
(GO:0007267)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to human chorionic gonadotropin stimulus
(GO:0044751)
Cytokine activity
(GO:0005125)
Dorsal/ventral pattern formation
(GO:0009953)
Embryonic heart tube development
(GO:0035050)
Endothelin a receptor binding
(GO:0031707)
Endothelin b receptor binding
(GO:0031708)
Epithelial fluid transport
(GO:0042045)
Gene expression
(GO:0010467)
Glomerular filtration
(GO:0003094)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heart development
(GO:0007507)
Heart process
(GO:0003015)
Histamine secretion
(GO:0001821)
Hormone activity
(GO:0005179)
Intracellular calcium ion homeostasis
(GO:0006874)
Intracellular signal transduction
(GO:0035556)
In utero embryonic development
(GO:0001701)
Mapk cascade
(GO:0000165)
Middle ear morphogenesis
(GO:0042474)
Mitochondrion organization
(GO:0007005)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of smooth muscle cell apoptotic process
(GO:0034392)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural crest cell development
(GO:0014032)
Neural crest cell differentiation
(GO:0014033)
Neural crest cell fate commitment
(GO:0014034)
Neuron projection development
(GO:0031175)
Neutrophil chemotaxis
(GO:0030593)
Nitric oxide transport
(GO:0030185)
Noradrenergic neuron differentiation
(GO:0003357)
Peptide hormone secretion
(GO:0030072)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Phospholipase d-activating g protein-coupled receptor signaling pathway
(GO:0031583)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cell size
(GO:0045793)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of heart rate
(GO:0010460)
Positive regulation of odontogenesis
(GO:0042482)
Positive regulation of prostaglandin secretion
(GO:0032308)
Positive regulation of renal sodium excretion
(GO:0035815)
Positive regulation of urine volume
(GO:0035810)
Prostaglandin biosynthetic process
(GO:0001516)
Protein kinase a signaling
(GO:0010737)
Protein kinase c-activating g protein-coupled receptor signaling pathway
(GO:0007205)
Protein kinase c deactivation
(GO:0042313)
Receptor ligand activity
(GO:0048018)
Regulation of blood pressure
(GO:0008217)
Regulation of glucose transmembrane transport
(GO:0010827)
Regulation of ph
(GO:0006885)
Regulation of systemic arterial blood pressure by endothelin
(GO:0003100)
Regulation of vasoconstriction
(GO:0019229)
Respiratory gaseous exchange by respiratory system
(GO:0007585)
Response to activity
(GO:0014823)
Response to amino acid
(GO:0043200)
Response to amphetamine
(GO:0001975)
Response to hypoxia
(GO:0001666)
Response to leptin
(GO:0044321)
Response to lipopolysaccharide
(GO:0032496)
Response to muscle stretch
(GO:0035994)
Response to nicotine
(GO:0035094)
Response to ozone
(GO:0010193)
Response to prostaglandin f
(GO:0034696)
Response to testosterone
(GO:0033574)
Response to xenobiotic stimulus
(GO:0009410)
Rhythmic excitation
(GO:0043179)
Signaling receptor binding
(GO:0005102)
Skeletal system development
(GO:0001501)
Smooth muscle contraction
(GO:0006939)
Superoxide anion generation
(GO:0042554)
Thyroid gland development
(GO:0030878)
Transcription by rna polymerase ii
(GO:0006366)
Vasoconstriction
(GO:0042310)
Vein smooth muscle contraction
(GO:0014826)

Other Information

Proteins

Endothelin-1

Genular Protein ID: 1911577600

Symbol: EDN1_RAT

Name: Endothelin-1

UniProtKB Accession Codes:

P22388

Database IDs:

Citations:

PubMed ID: 1840483

Title: cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA.

PubMed ID: 1840483

DOI: 10.1016/s0006-291x(05)81197-0

PubMed ID: 2039460

Title: Endothelin-1 mRNA expression in the rat kidney.

PubMed ID: 2039460

DOI: 10.1042/bj2750817

PubMed ID: 9508787

Title: Molecular characterization of a dual endothelin-1/Angiotensin II receptor.

PubMed ID: 9508787

DOI: 10.1007/bf03401733

PubMed ID: 26479776

Title: Peptidomics for studying limited proteolysis.

PubMed ID: 26479776

DOI: 10.1021/acs.jproteome.5b00820

Sequence Information:

Length: 202
Mass: 23135
Checksum: 701886BAFD09AC4B
Sequence:

MDYFPVIFSL LFVAFQGAPE TAVLGAELSP RAEKEVQSPP PSTSWRPRRS KRCSCSSLMD 
KECVYFCHLD IIWVNTPERV VPYGLGSPSR SKRSLKDLLP TKTTDQGNRC QCAHQKDKKC 
WNFCQADKEL RAQSTMQKGV KDFKKGKPCP KLGKKCIYQQ LVEGRKLRRL EAISNSIKTS 
FRVAKLKAEL YRDQKLIHNR AH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Edn1

Associated with

Other Information

cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA. PubMed ID: 1840483

Endothelin-1 mRNA expression in the rat kidney. PubMed ID: 2039460

Molecular characterization of a dual endothelin-1/Angiotensin II receptor. PubMed ID: 9508787

Peptidomics for studying limited proteolysis. PubMed ID: 26479776

Database document:

PubMed ID: 1840483

PubMed ID: 2039460

PubMed ID: 9508787

PubMed ID: 26479776