Details for: Egr1

Gene ID: 24330

Symbol: Egr1

Ensembl ID: ENSRNOG00000019422

Description: early growth response 1

Associated with

  • Bmp signaling pathway
    (GO:0030509)
  • Cellular response to antibiotic
    (GO:0071236)
  • Cellular response to camp
    (GO:0071320)
  • Cellular response to follicle-stimulating hormone stimulus
    (GO:0071372)
  • Cellular response to gamma radiation
    (GO:0071480)
  • Cellular response to gonadotropin stimulus
    (GO:0071371)
  • Cellular response to growth factor stimulus
    (GO:0071363)
  • Cellular response to heparin
    (GO:0071504)
  • Cellular response to hyperoxia
    (GO:0071455)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to insulin stimulus
    (GO:0032869)
  • Cellular response to interleukin-8
    (GO:0098759)
  • Cellular response to isoquinoline alkaloid
    (GO:0071317)
  • Cellular response to mechanical stimulus
    (GO:0071260)
  • Cellular response to mycophenolic acid
    (GO:0071506)
  • Cellular response to organic substance
    (GO:0071310)
  • Cellular response to steroid hormone stimulus
    (GO:0071383)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Chromatin
    (GO:0000785)
  • Circadian regulation of gene expression
    (GO:0032922)
  • Circadian rhythm
    (GO:0007623)
  • Circadian temperature homeostasis
    (GO:0060086)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Double-stranded dna binding
    (GO:0003690)
  • Double-stranded methylated dna binding
    (GO:0010385)
  • Estrous cycle
    (GO:0044849)
  • Glomerular mesangial cell proliferation
    (GO:0072110)
  • Hemi-methylated dna-binding
    (GO:0044729)
  • Histone acetyltransferase binding
    (GO:0035035)
  • Interleukin-1-mediated signaling pathway
    (GO:0070498)
  • Learning or memory
    (GO:0007611)
  • Locomotor rhythm
    (GO:0045475)
  • Long-term memory
    (GO:0007616)
  • Long-term synaptic potentiation
    (GO:0060291)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Oligodendrocyte differentiation
    (GO:0048709)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glomerular metanephric mesangial cell proliferation
    (GO:0072303)
  • Positive regulation of hormone biosynthetic process
    (GO:0046886)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of post-translational protein modification
    (GO:1901875)
  • Positive regulation of smooth muscle cell migration
    (GO:0014911)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of long-term neuronal synaptic plasticity
    (GO:0048169)
  • Regulation of neuron apoptotic process
    (GO:0043523)
  • Regulation of progesterone biosynthetic process
    (GO:2000182)
  • Regulation of protein sumoylation
    (GO:0033233)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to amphetamine
    (GO:0001975)
  • Response to carbon monoxide
    (GO:0034465)
  • Response to cocaine
    (GO:0042220)
  • Response to electrical stimulus
    (GO:0051602)
  • Response to ethanol
    (GO:0045471)
  • Response to follicle-stimulating hormone
    (GO:0032354)
  • Response to glucose
    (GO:0009749)
  • Response to gonadotropin
    (GO:0034698)
  • Response to hypoxia
    (GO:0001666)
  • Response to insulin
    (GO:0032868)
  • Response to ischemia
    (GO:0002931)
  • Response to norepinephrine
    (GO:0071873)
  • Response to nutrient levels
    (GO:0031667)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii core promoter sequence-specific dna binding
    (GO:0000979)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal muscle cell differentiation
    (GO:0035914)
  • T cell differentiation
    (GO:0030217)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 300844115

Symbol: EGR1_RAT

Name: Early growth response protein 1

UniProtKB Accession Codes:

P08154 Q53YM5

Database IDs:

AGR 1 AlphaFoldDB 1 CTD 1 EMBL 3 GO 86 Gene3D 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 UniProtKB 2 eggNOG 1

Citations:

PubMed ID: 3672127

Title: A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.

PubMed ID: 3672127

DOI: 10.1126/science.3672127

PubMed ID: 2492104

Title: Structure of the NGFI-A gene and detection of upstream sequences responsible for its transcriptional induction by nerve growth factor.

PubMed ID: 2492104

DOI: 10.1073/pnas.86.1.377

PubMed ID: 1859855

Title: Localization of the protein product of the immediate early growth response gene, Egr-1, in the kidney after ischemia and reperfusion.

PubMed ID: 1859855

DOI: 10.1091/mbc.2.3.251

PubMed ID: 8413279

Title: Transcriptional activity of the zinc finger protein NGFI-A is influenced by its interaction with a cellular factor.

PubMed ID: 8413279

DOI: 10.1128/mcb.13.11.6858-6865.1993

PubMed ID: 15220929

Title: Epigenetic programming by maternal behavior.

PubMed ID: 15220929

DOI: 10.1038/nn1276

Sequence Information:

  • Length: 508
  • Mass: 53935
  • Checksum: 3947BBA871BB8FA8
  • Sequence:
    • MDNYPKLEEM MLLSNGAPQF LGAAGTPEGS GGNNSSSSSS SSSGGGGGGG SNSGSSAFNP 
QGEPSEQPYE HLTTESFSDI ALNNEKALVE TSYPSQTTRL PPITYTGRFS LEPAPNSGNT 
LWPEPLFSLV SGLVSMTNPP TSSSSAPSPA ASSSSSASQS PPLSCAVPSN DSSPIYSAAP 
TFPTPNTDIF PEPQSQAFPG SAGTALQYPP PAYPATKGGF QVPMIPDYLF PQQQGDLSLG 
TPDQKPFQGL ENRTQQPSLT PLSTIKAFAT QSGSQDLKAL NNTYQSQLIK PSRMRKYPNR 
PSKTPPHERP YACPVESCDR RFSRSDELTR HIRIHTGQKP FQCRICMRNF SRSDHLTTHI 
RTHTGEKPFA CDICGRKFAR SDERKRHTKI HLRQKDKKAD KSVVASSAAS SLSSYPSPVA 
TSYPSPATTS FPSPVPTSYS SPGSSTYPSP AHSGFPSPSV ATTYASVPPA FPAQVSTFQS 
AGVSNSFSTS TGLSDMTATF SPRTIEIC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.