Genular: Defining Cellular Identity and Function

Details for: Gapdh

Gene ID: 24383

Symbol: Gapdh

Ensembl ID: ENSRNOG00000018630

Description: glyceraldehyde-3-phosphate dehydrogenase

Associated with

Glucose metabolism
(R-RNO-70326)
Glycolysis
(R-RNO-70171)
Metabolism
(R-RNO-1430728)
Metabolism of carbohydrates
(R-RNO-71387)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Apoptotic process
(GO:0006915)
Aspartic-type endopeptidase inhibitor activity
(GO:0019828)
Camp-mediated signaling
(GO:0019933)
Canonical glycolysis
(GO:0061621)
Cellular response to type ii interferon
(GO:0071346)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Disordered domain specific binding
(GO:0097718)
Enzyme binding
(GO:0019899)
Female pregnancy
(GO:0007565)
Gait complex
(GO:0097452)
Gluconeogenesis
(GO:0006094)
Glucose metabolic process
(GO:0006006)
Glutamatergic synapse
(GO:0098978)
Glyceraldehyde-3-phosphate dehydrogenase (nad+) (phosphorylating) activity
(GO:0004365)
Glycolytic process
(GO:0006096)
Identical protein binding
(GO:0042802)
Intracellular membrane-bounded organelle
(GO:0043231)
Lipid droplet
(GO:0005811)
Microtubule binding
(GO:0008017)
Microtubule cytoskeleton
(GO:0015630)
Microtubule cytoskeleton organization
(GO:0000226)
Nad binding
(GO:0051287)
Nadp binding
(GO:0050661)
Negative regulation of translation
(GO:0017148)
Negative regulation of vascular associated smooth muscle cell apoptotic process
(GO:1905460)
Neuron apoptotic process
(GO:0051402)
Nitric oxide mediated signal transduction
(GO:0007263)
Nuclear membrane
(GO:0031965)
Nucleus
(GO:0005634)
Peptidyl-cysteine s-nitrosylase activity
(GO:0035605)
Plasma membrane
(GO:0005886)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of type i interferon production
(GO:0032481)
Postsynaptic density, intracellular component
(GO:0099092)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)
Regulation of translation
(GO:0006417)
Ribonucleoprotein complex
(GO:1990904)
Transferase activity
(GO:0016740)

Other Information

Proteins

Glyceraldehyde-3-phosphate dehydrogenase

Genular Protein ID: 3188438276

Symbol: G3P_RAT

Name: Glyceraldehyde-3-phosphate dehydrogenase

UniProtKB Accession Codes:

P04797 P09328 Q5M916 Q9QWU4

Database IDs:

Citations:

PubMed ID: 2987824

Title: Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family.

PubMed ID: 2987824

DOI: 10.1093/nar/13.5.1431

PubMed ID: 2987855

Title: Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene.

PubMed ID: 2987855

DOI: 10.1093/nar/13.7.2485

PubMed ID: 10424669

Title: Over-expression of GAPDH induces apoptosis in COS-7 cells transfected with cloned GAPDH cDNAs.

PubMed ID: 10424669

DOI: 10.1097/00001756-199907130-00007

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3585333

Title: Trifluoperazine activates and releases latent ATP-generating enzymes associated with the synaptic plasma membrane.

PubMed ID: 3585333

DOI: 10.1111/j.1471-4159.1987.tb03420.x

PubMed ID: 6548307

Title: Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissues.

PubMed ID: 6548307

DOI: 10.1093/nar/12.18.6951

PubMed ID: 2413848

Title: 1.5 kb mRNA abundantly expressed in rat tumors encodes a 37 kilodalton protein in vitro.

PubMed ID: 2413848

DOI: 10.1016/0006-291x(85)91310-5

PubMed ID: 1281150

Title: Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.

PubMed ID: 1281150

DOI: 10.1016/s0021-9258(19)73985-4

PubMed ID: 8626764

Title: Posttranslational modification of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosylation and subsequent NADH attachment.

PubMed ID: 8626764

DOI: 10.1074/jbc.271.8.4209

PubMed ID: 15312048

Title: Interactions among p22, glyceraldehyde-3-phosphate dehydrogenase and microtubules.

PubMed ID: 15312048

DOI: 10.1042/bj20040622

PubMed ID: 15951807

Title: S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding.

PubMed ID: 15951807

DOI: 10.1038/ncb1268

PubMed ID: 17934141

Title: Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes: formation of S-(2-succinyl)cysteine, a novel chemical modification of protein and possible biomarker of mitochondrial stress.

PubMed ID: 17934141

DOI: 10.2337/db07-0838

PubMed ID: 19607794

Title: GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation.

PubMed ID: 19607794

DOI: 10.1016/j.neuron.2009.05.024

PubMed ID: 20972425

Title: GAPDH mediates nitrosylation of nuclear proteins.

PubMed ID: 20972425

DOI: 10.1038/ncb2114

Sequence Information:

Length: 333
Mass: 35828
Checksum: D9E5ED4F38544C77
Sequence:

MVKVGVNGFG RIGRLVTRAA FSCDKVDIVA INDPFIDLNY MVYMFQYDST HGKFNGTVKA 
ENGKLVINGK PITIFQERDP ANIKWGDAGA EYVVESTGVF TTMEKAGAHL KGGAKRVIIS 
APSADAPMFV MGVNHEKYDN SLKIVSNASC TTNCLAPLAK VIHDNFGIVE GLMTTVHAIT 
ATQKTVDGPS GKLWRDGRGA AQNIIPASTG AAKAVGKVIP ELNGKLTGMA FRVPTPNVSV 
VDLTCRLEKP AKYDDIKKVV KQAAEGPLKG ILGYTEDQVV SCDFNSNSHS STFDAGAGIA 
LNDNFVKLIS WYDNEYGYSN RVVDLMAYMA SKE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gapdh

Associated with

Other Information

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. PubMed ID: 2987824

Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. PubMed ID: 2987855

Over-expression of GAPDH induces apoptosis in COS-7 cells transfected with cloned GAPDH cDNAs. PubMed ID: 10424669

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Trifluoperazine activates and releases latent ATP-generating enzymes associated with the synaptic plasma membrane. PubMed ID: 3585333

Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissues. PubMed ID: 6548307

1.5 kb mRNA abundantly expressed in rat tumors encodes a 37 kilodalton protein in vitro. PubMed ID: 2413848

Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. PubMed ID: 1281150

Posttranslational modification of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosylation and subsequent NADH attachment. PubMed ID: 8626764

Interactions among p22, glyceraldehyde-3-phosphate dehydrogenase and microtubules. PubMed ID: 15312048

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. PubMed ID: 15951807

Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes: formation of S-(2-succinyl)cysteine, a novel chemical modification of protein and possible biomarker of mitochondrial stress. PubMed ID: 17934141

GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. PubMed ID: 19607794

GAPDH mediates nitrosylation of nuclear proteins. PubMed ID: 20972425