Details for: Gfi1

Gene ID: 24388

Symbol: Gfi1

Ensembl ID: ENSRNOG00000002042

Description: growth factor independent 1 transcriptional repressor

Associated with

  • Biological_process
    (GO:0008150)
  • Cell fate commitment
    (GO:0045165)
  • Cell fate specification
    (GO:0001708)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription repressor activity
    (GO:0001217)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Inner ear auditory receptor cell differentiation
    (GO:0042491)
  • Inner ear morphogenesis
    (GO:0042472)
  • Mechanosensory behavior
    (GO:0007638)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of cell fate specification
    (GO:0009996)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of neuron projection development
    (GO:0010977)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear body
    (GO:0016604)
  • Nuclear matrix
    (GO:0016363)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell fate specification
    (GO:0042660)
  • Positive regulation of interleukin-6-mediated signaling pathway
    (GO:0070105)
  • Protein binding
    (GO:0005515)
  • Regulation of toll-like receptor signaling pathway
    (GO:0034121)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription repressor complex
    (GO:0017053)

Other Information

Genular Protein ID: 2811782328

Symbol: GFI1_RAT

Name: Zinc finger protein Gfi-1

UniProtKB Accession Codes:

Q07120

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 CTD 1 DIP 1 EMBL 1 Ensembl 4 EvolutionaryTrace 1 GO 25 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8441411

Title: Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein.

PubMed ID: 8441411

DOI: 10.1128/mcb.13.3.1759-1768.1993

PubMed ID: 20190815

Title: A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A.

PubMed ID: 20190815

DOI: 10.1038/onc.2010.48

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 20153336

Title: Solution structure of Gfi-1 zinc domain bound to consensus DNA.

PubMed ID: 20153336

DOI: 10.1016/j.jmb.2010.02.006

Sequence Information:

  • Length: 423
  • Mass: 45858
  • Checksum: FC39B6100D684D14
  • Sequence:
    • MPRSFLVKSK KAHSYHQPRS PGPDYSLRLE TVPVPGRADG GAVSAGESKM EPRERLSPES 
QLTEAPDRAS ASPNSCEGSV CDPSSEFEDY WRPPSPSVSP ASEKSLCRSL DEAQPYTLPF 
KPYAWSGLAG SDLRHLVQSY RQCSALERSA GLSLFCERGA ESGRPAARYG SEQAAGGAGA 
GQPGSCGAAS GATSAGGLGL YGDFAPAAAG LFERPSTAAG RLYQDRGHEL HADKSVGVKV 
ESELLCTRLL LGGGSYKCIK CSKVFSTPHG LEVHVRRSHS GTRPFACEMC GKTFGHAVSL 
EQHKAVHSQE RSFDCKICGK SFKRSSTLST HLLIHSDTRP YPCQYCGKRF HQKSDMKKHT 
FIHTGEKPHK CQVCGKAFSQ SSNLITHSRK HTGFKPFGCD LCGKGFQRKV DLRRHRETQH 
GLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.