Genular: Defining Cellular Identity and Function

Details for: Gja1

Gene ID: 24392

Symbol: Gja1

Ensembl ID: ENSRNOG00000000805

Description: gap junction protein, alpha 1

Associated with

Formation of annular gap junctions
(R-RNO-196025)
Gap junction degradation
(R-RNO-190873)
Gap junction trafficking
(R-RNO-190828)
Gap junction trafficking and regulation
(R-RNO-157858)
Membrane trafficking
(R-RNO-199991)
Microtubule-dependent trafficking of connexons from golgi to the plasma membrane
(R-RNO-190840)
Regulation of gap junction activity
(R-RNO-191650)
Rho gtpase cycle
(R-RNO-9012999)
Rhoq gtpase cycle
(R-RNO-9013406)
Signaling by rho gtpases
(R-RNO-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-RNO-9716542)
Transport of connexons to the plasma membrane
(R-RNO-190872)
Vesicle-mediated transport
(R-RNO-5653656)
Adult heart development
(GO:0007512)
Alpha-tubulin binding
(GO:0043014)
Atp transport
(GO:0015867)
Atrial ventricular junction remodeling
(GO:0003294)
Beta-catenin binding
(GO:0008013)
Beta-tubulin binding
(GO:0048487)
Cell-cell signaling
(GO:0007267)
Cell communication by chemical coupling
(GO:0010643)
Cell communication by electrical coupling
(GO:0010644)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Chronic inflammatory response
(GO:0002544)
Columnar/cuboidal epithelial cell maturation
(GO:0002069)
Connexin binding
(GO:0071253)
Disordered domain specific binding
(GO:0097718)
Efflux transmembrane transporter activity
(GO:0015562)
Embryonic digit morphogenesis
(GO:0042733)
Embryonic heart tube development
(GO:0035050)
Endothelium development
(GO:0003158)
Establishment of mitotic spindle orientation
(GO:0000132)
Gap junction assembly
(GO:0016264)
Gap junction channel activity
(GO:0005243)
Gap junction channel activity involved in cell communication by electrical coupling
(GO:1903763)
Gap junction hemi-channel activity
(GO:0055077)
Glutamate secretion
(GO:0014047)
Glutathione transmembrane transport
(GO:0034775)
Glutathione transmembrane transporter activity
(GO:0034634)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
In utero embryonic development
(GO:0001701)
Lens development in camera-type eye
(GO:0002088)
Maintenance of protein localization in endoplasmic reticulum
(GO:0035437)
Male gonad development
(GO:0008584)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transmembrane transporter activity
(GO:0015075)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of endothelial cell proliferation
(GO:0001937)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of gonadotropin secretion
(GO:0032277)
Neuron migration
(GO:0001764)
Osteoblast differentiation
(GO:0001649)
Pdz domain binding
(GO:0030165)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell communication by chemical coupling
(GO:0010652)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glomerular filtration
(GO:0003104)
Positive regulation of insulin secretion
(GO:0032024)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein localization
(GO:0008104)
Protein tyrosine kinase binding
(GO:1990782)
Regulation of apoptotic process
(GO:0042981)
Regulation of bone mineralization
(GO:0030500)
Regulation of cell communication by electrical coupling
(GO:0010649)
Regulation of heart contraction
(GO:0008016)
Response to estradiol
(GO:0032355)
Response to fluid shear stress
(GO:0034405)
Response to glucose
(GO:0009749)
Response to ischemia
(GO:0002931)
Response to lipopolysaccharide
(GO:0032496)
Response to ph
(GO:0009268)
Response to retinoic acid
(GO:0032526)
Response to wounding
(GO:0009611)
Scaffold protein binding
(GO:0097110)
Sh3 domain binding
(GO:0017124)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Skeletal muscle tissue regeneration
(GO:0043403)
Spermatogenesis
(GO:0007283)
T cell activation
(GO:0042110)
T cell proliferation
(GO:0042098)
Transmembrane transporter activity
(GO:0022857)
Tubulin binding
(GO:0015631)
Vascular transport
(GO:0010232)
Vasodilation
(GO:0042311)
Xenobiotic transport
(GO:0042908)

Other Information

Proteins

Gap junction alpha-1 protein

Genular Protein ID: 2537270430

Symbol: CXA1_RAT

Name: Gap junction alpha-1 protein

UniProtKB Accession Codes:

P08050 Q53ZE1

Database IDs:

Citations:

PubMed ID: 2826492

Title: Connexin43: a protein from rat heart homologous to a gap junction protein from liver.

PubMed ID: 2826492

DOI: 10.1083/jcb.105.6.2621

PubMed ID: 1852114

Title: Molecular cloning of a rat uterine gap junction protein and analysis of gene expression during gestation.

PubMed ID: 1852114

DOI: 10.1152/ajpendo.1991.260.5.e787

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2987225

Title: The Mr 28,000 gap junction proteins from rat heart and liver are different but related.

PubMed ID: 2987225

DOI: 10.1016/s0021-9258(18)88810-x

PubMed ID: 1652440

Title: Affinity purification of a rat-brain junctional protein, connexin 43.

PubMed ID: 1652440

DOI: 10.1111/j.1432-1033.1991.tb21075.x

PubMed ID: 2472402

Title: The 43-kD polypeptide of heart gap junctions: immunolocalization, topology, and functional domains.

PubMed ID: 2472402

DOI: 10.1083/jcb.108.6.2241

PubMed ID: 1651718

Title: Connexon integrity is maintained by non-covalent bonds: intramolecular disulfide bonds link the extracellular domains in rat connexin-43.

PubMed ID: 1651718

DOI: 10.1016/0006-291x(91)91037-d

PubMed ID: 12417300

Title: Identification and functional analysis of novel phosphorylation sites in Cx43 in rat primary granulosa cells.

PubMed ID: 12417300

DOI: 10.1016/s0014-5793(02)03441-5

PubMed ID: 15181016

Title: Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells.

PubMed ID: 15181016

DOI: 10.1074/jbc.m404073200

PubMed ID: 15213231

Title: CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression.

PubMed ID: 15213231

DOI: 10.1074/jbc.m403952200

PubMed ID: 20127391

Title: NMR structure note: UBA domain of CIP75.

PubMed ID: 20127391

DOI: 10.1007/s10858-010-9397-9

PubMed ID: 22549838

Title: Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm.

PubMed ID: 22549838

DOI: 10.1038/ncomms1812

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 24500718

Title: Protein kinase Cdelta-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation.

PubMed ID: 24500718

DOI: 10.1074/jbc.m113.533265

PubMed ID: 1371548

Title: Membrane topology and quaternary structure of cardiac gap junction ion channels.

PubMed ID: 1371548

DOI: 10.1016/0022-2836(92)90253-g

PubMed ID: 15492000

Title: Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1.

PubMed ID: 15492000

DOI: 10.1074/jbc.m409552200

PubMed ID: 18636092

Title: Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites.

PubMed ID: 18636092

DOI: 10.1038/emboj.2008.138

Sequence Information:

Length: 382
Mass: 43031
Checksum: 0196416EA6A69490
Sequence:

MGDWSALGKL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS AFRCNTQQPG 
CENVCYDKSF PISHVRFWVL QIIFVSVPTL LYLAHVFYVM RKEEKLNKKE EELKVAQTDG 
VNVEMHLKQI EIKKFKYGIE EHGKVKMRGG LLRTYIISIL FKSVFEVAFL LIQWYIYGFS 
LSAVYTCKRD PCPHQVDCFL SRPTEKTIFI IFMLVVSLVS LALNIIELFY VFFKGVKDRV 
KGRSDPYHAT TGPLSPSKDC GSPKYAYFNG CSSPTAPLSP MSPPGYKLVT GDRNNSSCRN 
YNKQASEQNW ANYSAEQNRM GQAGSTISNS HAQPFDFPDD NQNAKKVAAG HELQPLAIVD 
QRPSSRASSR ASSRPRPDDL EI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gja1

Associated with

Other Information

Connexin43: a protein from rat heart homologous to a gap junction protein from liver. PubMed ID: 2826492

Molecular cloning of a rat uterine gap junction protein and analysis of gene expression during gestation. PubMed ID: 1852114

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The Mr 28,000 gap junction proteins from rat heart and liver are different but related. PubMed ID: 2987225

Affinity purification of a rat-brain junctional protein, connexin 43. PubMed ID: 1652440

The 43-kD polypeptide of heart gap junctions: immunolocalization, topology, and functional domains. PubMed ID: 2472402

Connexon integrity is maintained by non-covalent bonds: intramolecular disulfide bonds link the extracellular domains in rat connexin-43. PubMed ID: 1651718

Identification and functional analysis of novel phosphorylation sites in Cx43 in rat primary granulosa cells. PubMed ID: 12417300

Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. PubMed ID: 15181016

CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression. PubMed ID: 15213231

NMR structure note: UBA domain of CIP75. PubMed ID: 20127391

Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm. PubMed ID: 22549838

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Protein kinase Cdelta-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation. PubMed ID: 24500718

Membrane topology and quaternary structure of cardiac gap junction ion channels. PubMed ID: 1371548

Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1. PubMed ID: 15492000

Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites. PubMed ID: 18636092