Genular: Defining Cellular Identity and Function

Details for: Gls

Gene ID: 24398

Symbol: Gls

Ensembl ID: ENSRNOG00000056246

Description: glutaminase

Associated with

Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Glutamate and glutamine metabolism
(R-RNO-8964539)
Glutamate neurotransmitter release cycle
(R-RNO-210500)
Metabolism
(R-RNO-1430728)
Metabolism of amino acids and derivatives
(R-RNO-71291)
Neuronal system
(R-RNO-112316)
Neurotransmitter release cycle
(R-RNO-112310)
Rna polymerase ii transcription
(R-RNO-73857)
Tp53 regulates metabolic genes
(R-RNO-5628897)
Transcriptional regulation by tp53
(R-RNO-3700989)
Transmission across chemical synapses
(R-RNO-112315)
Chemical synaptic transmission
(GO:0007268)
Cytosol
(GO:0005829)
Glutamate biosynthetic process
(GO:0006537)
Glutaminase activity
(GO:0004359)
Glutamine catabolic process
(GO:0006543)
Glutamine metabolic process
(GO:0006541)
Identical protein binding
(GO:0042802)
Intracellular glutamate homeostasis
(GO:0090461)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Protein binding
(GO:0005515)
Protein homotetramerization
(GO:0051289)
Regulation of respiratory gaseous exchange by nervous system process
(GO:0002087)
Suckling behavior
(GO:0001967)
Synapse
(GO:0045202)

Other Information

Proteins

Glutaminase kidney isoform, mitochondrial

Genular Protein ID: 2760968203

Symbol: GLSK_RAT

Name: Glutaminase kidney isoform, mitochondrial

UniProtKB Accession Codes:

P13264 Q8R421

Database IDs:

Citations:

PubMed ID: 1918000

Title: Isolation, characterization, and in vitro expression of a cDNA that encodes the kidney isoenzyme of the mitochondrial glutaminase.

PubMed ID: 1918000

DOI: 10.1016/s0021-9258(18)55132-2

PubMed ID: 11267668

Title: Isolation and characterization of the promoter region of the rat kidney-type glutaminase gene.

PubMed ID: 11267668

DOI: 10.1016/s0167-4781(01)00183-x

PubMed ID: 12045296

Title: Complexity and species variation of the kidney-type glutaminase gene.

PubMed ID: 12045296

DOI: 10.1152/physiolgenomics.00017.2002

PubMed ID: 3401701

Title: Isolation of a cDNA for rat brain glutaminase.

PubMed ID: 3401701

DOI: 10.1016/0169-328x(88)90047-2

PubMed ID: 1991024

Title: Biosynthesis and processing of mitochondrial glutaminase in HTC hepatoma cells.

PubMed ID: 1991024

DOI: 10.1042/bj2730265

PubMed ID: 7836378

Title: In vitro characterization of the mitochondrial processing and the potential function of the 68-kDa subunit of renal glutaminase.

PubMed ID: 7836378

DOI: 10.1074/jbc.270.3.1185

PubMed ID: 16899818

Title: Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels.

PubMed ID: 16899818

DOI: 10.1242/jcs.03061

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 22228304

Title: Mitochondrial localization and structure-based phosphate activation mechanism of glutaminase C with implications for cancer metabolism.

PubMed ID: 22228304

DOI: 10.1073/pnas.1112495109

PubMed ID: 23935106

Title: Active glutaminase C self-assembles into a supratetrameric oligomer that can be disrupted by an allosteric inhibitor.

PubMed ID: 23935106

DOI: 10.1074/jbc.m113.501346

Sequence Information:

Length: 674
Mass: 74024
Checksum: 4B2524A45D3678CA
Sequence:

MMRLRGSAML RELLLRPPAA VGGVLRRTQP LGTLCRRPRG GSRPAAGLVA AARLHPWWGG 
GGRAKGPGSG GLSSSPSEIL QELGKGGTPP QQQQQQQQQP GASPPAAPGP KDSPGETDAF 
GNSEGKEMVA AGDNKVKQGL LPSLEDLLFY TIAEGQEKIP VHKFITALKS TGLRTSDPRL 
KECMDMLRLT LQTTSDGVML DKDLFKKCVQ SNIVLLTQAF RRKFVIPDFM SFTSHIDELY 
ESAKKQSGGK VADYIPQLAK FSPDLWGVSV CTVDGQRHSI GDTKVPFCLQ SCVKPLKYAI 
AVNDLGTEYV HRYVGKEPSG LRFNKLFLNE DDKPHNPMVN AGAIVVTSLI KQGVNNAEKF 
DYVMQFLNKM AGNEYVGFSN ATFQSERESG DRNFAIGYYL KEKKCFPEGT DMVGILDFYF 
QLCSIEVTCE SASVMAATLA NGGFCPITGE RVLSPEAVRN TLSLMHSCGM YDFSGQFAFH 
VGLPAKSGVA GGILLVVPNV MGMMCWSPPL DKMGNSVKGI HFCHDLVSLC NFHNYDNLRH 
FAKKLDPRRE GGDQRVKSVI NLLFAAYTGD VSALRRFALS AMDMEQRDYD SRTALHVAAA 
EGHVEVVKFL LEACKVNPFP KDRWNNTPMD EALHFGHHDV FKILQEYQVQ YTPQGDSDDG 
KENQTVHKNL DGLL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gls

Associated with

Other Information

Isolation, characterization, and in vitro expression of a cDNA that encodes the kidney isoenzyme of the mitochondrial glutaminase. PubMed ID: 1918000

Isolation and characterization of the promoter region of the rat kidney-type glutaminase gene. PubMed ID: 11267668

Complexity and species variation of the kidney-type glutaminase gene. PubMed ID: 12045296

Isolation of a cDNA for rat brain glutaminase. PubMed ID: 3401701

Biosynthesis and processing of mitochondrial glutaminase in HTC hepatoma cells. PubMed ID: 1991024

In vitro characterization of the mitochondrial processing and the potential function of the 68-kDa subunit of renal glutaminase. PubMed ID: 7836378

Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels. PubMed ID: 16899818

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Mitochondrial localization and structure-based phosphate activation mechanism of glutaminase C with implications for cancer metabolism. PubMed ID: 22228304

Active glutaminase C self-assembles into a supratetrameric oligomer that can be disrupted by an allosteric inhibitor. PubMed ID: 23935106