Genular: Defining Cellular Identity and Function

Details for: Got1

Gene ID: 24401

Symbol: Got1

Ensembl ID: ENSRNOG00000016356

Description: glutamic-oxaloacetic transaminase 1

Associated with

Aspartate and asparagine metabolism
(R-RNO-8963693)
Glucose metabolism
(R-RNO-70326)
Metabolism
(R-RNO-1430728)
Metabolism of amino acids and derivatives
(R-RNO-71291)
Metabolism of carbohydrates
(R-RNO-71387)
2-oxoglutarate metabolic process
(GO:0006103)
Amino acid biosynthetic process
(GO:0008652)
Aspartate biosynthetic process
(GO:0006532)
Aspartate catabolic process
(GO:0006533)
Aspartate metabolic process
(GO:0006531)
Axon terminus
(GO:0043679)
Carboxylic acid binding
(GO:0031406)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to mechanical stimulus
(GO:0071260)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dicarboxylic acid metabolic process
(GO:0043648)
Fatty acid homeostasis
(GO:0055089)
Gluconeogenesis
(GO:0006094)
Glutamate catabolic process to 2-oxoglutarate
(GO:0019551)
Glutamate catabolic process to aspartate
(GO:0019550)
Glutamate metabolic process
(GO:0006536)
Glycerol biosynthetic process
(GO:0006114)
L-aspartate:2-oxoglutarate aminotransferase activity
(GO:0004069)
L-cysteine transaminase activity
(GO:0047801)
Negative regulation of collagen biosynthetic process
(GO:0032966)
Negative regulation of cytosolic calcium ion concentration
(GO:0051481)
Negative regulation of mitochondrial depolarization
(GO:0051902)
Notch signaling pathway
(GO:0007219)
Oxaloacetate metabolic process
(GO:0006107)
Phosphatidylserine decarboxylase activity
(GO:0004609)
Positive regulation of transforming growth factor beta receptor signaling pathway
(GO:0030511)
Pyridoxal phosphate binding
(GO:0030170)
Response to cadmium ion
(GO:0046686)
Response to carbohydrate
(GO:0009743)
Response to glucocorticoid
(GO:0051384)
Response to immobilization stress
(GO:0035902)
Response to transition metal nanoparticle
(GO:1990267)
Transaminase activity
(GO:0008483)
Transdifferentiation
(GO:0060290)

Other Information

Proteins

Cysteine aminotransferase, cytoplasmic

Genular Protein ID: 3782582401

Symbol: AATC_RAT

Name: Cysteine aminotransferase, cytoplasmic

UniProtKB Accession Codes:

P13221 Q64570 Q6P721

Database IDs:

Citations:

PubMed ID: 3182856

Title: Nucleotide sequence and glucocorticoid regulation of the mRNAs for the isoenzymes of rat aspartate aminotransferase.

PubMed ID: 3182856

DOI: 10.1016/s0021-9258(19)77858-2

PubMed ID: 3053674

Title: Rat cytosolic aspartate aminotransferase: molecular cloning of cDNA and expression in Escherichia coli.

PubMed ID: 3053674

DOI: 10.1093/oxfordjournals.jbchem.a122349

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2307672

Title: Hormonal discrimination among transcription start sites of aspartate aminotransferase.

PubMed ID: 2307672

DOI: 10.1016/s0021-9258(19)39584-5

PubMed ID: 7113743

Title: Purification and characterization of cysteine aminotransferase from rat liver cytosol.

PubMed ID: 7113743

DOI: 10.18926/amo/30697

PubMed ID: 3182750

Title: Rat cytosolic aspartate aminotransferase: regulation of its mRNA and contribution to gluconeogenesis.

PubMed ID: 3182750

DOI: 10.1093/oxfordjournals.jbchem.a122350

PubMed ID: 17545671

Title: Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione.

PubMed ID: 17545671

DOI: 10.1074/jbc.m611111200

PubMed ID: 21361730

Title: Oxygen-inducible glutamate oxaloacetate transaminase as protective switch transforming neurotoxic glutamate to metabolic fuel during acute ischemic stroke.

PubMed ID: 21361730

DOI: 10.1089/ars.2011.3930

PubMed ID: 21266983

Title: Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study.

PubMed ID: 21266983

DOI: 10.1038/jcbfm.2011.3

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 413
Mass: 46429
Checksum: A9425BF05AC24C08
Sequence:

MAPPSFFAQV PQAPPVLVFK LIADFRDDPD PRKVNLGVGA YRTDDSQPWV LPVVRKVEQK 
IANDHSLNHE YLPILGLAEF RSCASQLVLG DNSPALRENR VGGVQSLGGT GALRIGADFL 
GRWYNGTDNK NTPVYVSSPT WENHNGVFSA AGFKDIRSYR YWDAEKRGLD LQGFLNDLEN 
APEFSIFVLH ACAHNPTGTD PTEEEWKQIA AVMKRRFLFP FFDSAYQGFA SGDLEKDAWA 
IRYFVSEGFE LFCAQSFSKN FGLYNERVGN LTVVGKEHDS VLRVLSQMEK IVRITWSNPP 
AQGARIVATT LSNPELFKEW KGNVKTMADR ILTMRSELRA RLEALKTPGT WSHITEQIGM 
FSFTGLNPKQ VEYLVNEKHI YLMPSGRINM CGLTTKNLDY VATSINEAVT KFQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Got1

Associated with

Other Information

Nucleotide sequence and glucocorticoid regulation of the mRNAs for the isoenzymes of rat aspartate aminotransferase. PubMed ID: 3182856

Rat cytosolic aspartate aminotransferase: molecular cloning of cDNA and expression in Escherichia coli. PubMed ID: 3053674

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hormonal discrimination among transcription start sites of aspartate aminotransferase. PubMed ID: 2307672

Purification and characterization of cysteine aminotransferase from rat liver cytosol. PubMed ID: 7113743

Rat cytosolic aspartate aminotransferase: regulation of its mRNA and contribution to gluconeogenesis. PubMed ID: 3182750

Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione. PubMed ID: 17545671

Oxygen-inducible glutamate oxaloacetate transaminase as protective switch transforming neurotoxic glutamate to metabolic fuel during acute ischemic stroke. PubMed ID: 21361730

Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study. PubMed ID: 21266983

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903