Genular: Defining Cellular Identity and Function

Details for: Gpx1

Gene ID: 24404

Symbol: Gpx1

Ensembl ID: ENSRNOG00000048812

Description: glutathione peroxidase 1

Associated with

Arachidonic acid metabolism
(R-RNO-2142753)
Cellular responses to stimuli
(R-RNO-8953897)
Cellular responses to stress
(R-RNO-2262752)
Cellular response to chemical stress
(R-RNO-9711123)
Detoxification of reactive oxygen species
(R-RNO-3299685)
Fatty acid metabolism
(R-RNO-8978868)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Synthesis of 12-eicosatetraenoic acid derivatives
(R-RNO-2142712)
Synthesis of 15-eicosatetraenoic acid derivatives
(R-RNO-2142770)
Angiogenesis involved in wound healing
(GO:0060055)
Apoptotic process
(GO:0006915)
Arachidonic acid metabolic process
(GO:0019369)
Biological process involved in interaction with symbiont
(GO:0051702)
Blood vessel endothelial cell migration
(GO:0043534)
Cell redox homeostasis
(GO:0045454)
Cellular oxidant detoxification
(GO:0098869)
Cellular response to glucose stimulus
(GO:0071333)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endothelial cell development
(GO:0001885)
Epigenetic regulation of gene expression
(GO:0040029)
Fat cell differentiation
(GO:0045444)
Fibroblast proliferation
(GO:0048144)
Glutathione metabolic process
(GO:0006749)
Glutathione peroxidase activity
(GO:0004602)
Heart contraction
(GO:0060047)
Hydrogen peroxide catabolic process
(GO:0042744)
Intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0008631)
Lewy body
(GO:0097413)
Lipid metabolic process
(GO:0006629)
Lipoxygenase pathway
(GO:0019372)
Mitochondrion
(GO:0005739)
Myoblast differentiation
(GO:0045445)
Myoblast proliferation
(GO:0051450)
Myotube differentiation
(GO:0014902)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902042)
Negative regulation of inflammatory response to antigenic stimulus
(GO:0002862)
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
(GO:1902176)
Negative regulation of release of cytochrome c from mitochondria
(GO:0090201)
Neuron apoptotic process
(GO:0051402)
Peroxidase activity
(GO:0004601)
Phospholipid-hydroperoxide glutathione peroxidase activity
(GO:0047066)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Regulation of mammary gland epithelial cell proliferation
(GO:0033599)
Regulation of proteasomal protein catabolic process
(GO:0061136)
Response to estradiol
(GO:0032355)
Response to folic acid
(GO:0051593)
Response to gamma radiation
(GO:0010332)
Response to glucose
(GO:0009749)
Response to hormone
(GO:0009725)
Response to hydrogen peroxide
(GO:0042542)
Response to hydroperoxide
(GO:0033194)
Response to nicotine
(GO:0035094)
Response to organic cyclic compound
(GO:0014070)
Response to oxidative stress
(GO:0006979)
Response to reactive oxygen species
(GO:0000302)
Response to selenium ion
(GO:0010269)
Response to symbiotic bacterium
(GO:0009609)
Response to toxic substance
(GO:0009636)
Response to vitamin e
(GO:0033197)
Response to wounding
(GO:0009611)
Response to xenobiotic stimulus
(GO:0009410)
Sensory perception of sound
(GO:0007605)
Sh3 domain binding
(GO:0017124)
Skeletal muscle fiber development
(GO:0048741)
Skeletal muscle tissue regeneration
(GO:0043403)
Temperature homeostasis
(GO:0001659)
Triglyceride metabolic process
(GO:0006641)
Uv protection
(GO:0009650)
Vasodilation
(GO:0042311)

Other Information

Proteins

Cellular glutathione peroxidase

Genular Protein ID: 1160595818

Symbol: GPX1_RAT

Name: Cellular glutathione peroxidase

UniProtKB Accession Codes:

P04041 O08946 Q4PIY2 Q91WZ5

Database IDs:

Citations:

PubMed ID: 3408482

Title: Determination of nucleotide sequence of cDNA coding rat glutathione peroxidase and diminished expression of the mRNA in selenium deficient rat liver.

PubMed ID: 3408482

DOI: 10.1016/0006-291x(88)90242-2

PubMed ID: 3387231

Title: Nucleotide sequence of a rat glutathione peroxidase cDNA.

PubMed ID: 3387231

DOI: 10.1093/nar/16.11.5207

PubMed ID: 2838821

Title: Expression of glutathione peroxidase I gene in selenium-deficient rats.

PubMed ID: 2838821

DOI: 10.1093/nar/16.12.5557

PubMed ID: 1451786

Title: Cloning and characterization of the rat glutathione peroxidase gene.

PubMed ID: 1451786

DOI: 10.1016/0014-5793(92)80198-p

PubMed ID: 1640255

Title: Dietary selenium stabilizes glutathione peroxidase mRNA in rat liver.

PubMed ID: 1640255

DOI: 10.1093/jn/122.8.1620

PubMed ID: 6217842

Title: Amino acid sequence around the active-site selenocysteine of rat liver glutathione peroxidase.

PubMed ID: 6217842

DOI: 10.1016/0167-4838(82)90472-1

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 201
Mass: 22305
Checksum: 093528A214615A11
Sequence:

MSAARLSAVA QSTVYAFSAR PLAGGEPVSL GSLRGKVLLI ENVASLUGTT TRDYTEMNDL 
QKRLGPRGLV VLGFPCNQFG HQENGKNEEI LNSLKYVRPG GGFEPNFTLF EKCEVNGEKA 
HPLFTFLRNA LPAPSDDPTA LMTDPKYIIW SPVCRNDISW NFEKFLVGPD GVPVRRYSRR 
FRTIDIEPDI EALLSKQPSN P

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gpx1

Associated with

Other Information

Determination of nucleotide sequence of cDNA coding rat glutathione peroxidase and diminished expression of the mRNA in selenium deficient rat liver. PubMed ID: 3408482

Nucleotide sequence of a rat glutathione peroxidase cDNA. PubMed ID: 3387231

Expression of glutathione peroxidase I gene in selenium-deficient rats. PubMed ID: 2838821

Cloning and characterization of the rat glutathione peroxidase gene. PubMed ID: 1451786

Dietary selenium stabilizes glutathione peroxidase mRNA in rat liver. PubMed ID: 1640255

Amino acid sequence around the active-site selenocysteine of rat liver glutathione peroxidase. PubMed ID: 6217842

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903