Details for: Grin2d

Gene ID: 24412

Symbol: Grin2d

Ensembl ID: ENSRNOG00000021063

Description: glutamate ionotropic receptor NMDA type subunit 2D

Associated with

  • Activation of nmda receptors and postsynaptic events
    (R-RNO-442755)
  • Assembly and cell surface presentation of nmda receptors
    (R-RNO-9609736)
  • Mapk1/mapk3 signaling
    (R-RNO-5684996)
  • Mapk family signaling cascades
    (R-RNO-5683057)
  • Neuronal system
    (R-RNO-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-RNO-112314)
  • Protein-protein interactions at synapses
    (R-RNO-6794362)
  • Raf/map kinase cascade
    (R-RNO-5673001)
  • Signal transduction
    (R-RNO-162582)
  • Synaptic adhesion-like molecules
    (R-RNO-8849932)
  • Transmission across chemical synapses
    (R-RNO-112315)
  • Unblocking of nmda receptors, glutamate binding and activation
    (R-RNO-438066)
  • Adult locomotory behavior
    (GO:0008344)
  • Calcium-mediated signaling
    (GO:0019722)
  • Calcium ion transmembrane import into cytosol
    (GO:0097553)
  • Cellular response to l-glutamate
    (GO:1905232)
  • Detection of mechanical stimulus involved in sensory perception of pain
    (GO:0050966)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Excitatory postsynaptic potential
    (GO:0060079)
  • Glutamate-gated calcium ion channel activity
    (GO:0022849)
  • Glutamate-gated receptor activity
    (GO:0004970)
  • Glutamate binding
    (GO:0016595)
  • Glutamatergic synapse
    (GO:0098978)
  • Hippocampal mossy fiber to ca3 synapse
    (GO:0098686)
  • Ionotropic glutamate receptor complex
    (GO:0008328)
  • Ionotropic glutamate receptor signaling pathway
    (GO:0035235)
  • Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
    (GO:0099507)
  • Long-term synaptic potentiation
    (GO:0060291)
  • Monoatomic cation channel activity
    (GO:0005261)
  • Monoatomic cation transmembrane transport
    (GO:0098655)
  • Nmda glutamate receptor activity
    (GO:0004972)
  • Nmda selective glutamate receptor complex
    (GO:0017146)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of excitatory postsynaptic potential
    (GO:2000463)
  • Positive regulation of synaptic transmission, glutamatergic
    (GO:0051968)
  • Postsynaptic density membrane
    (GO:0098839)
  • Postsynaptic membrane
    (GO:0045211)
  • Presynaptic active zone membrane
    (GO:0048787)
  • Protein binding
    (GO:0005515)
  • Regulation of monoatomic cation transmembrane transport
    (GO:1904062)
  • Regulation of neuronal synaptic plasticity
    (GO:0048168)
  • Regulation of presynaptic membrane potential
    (GO:0099505)
  • Regulation of sensory perception of pain
    (GO:0051930)
  • Startle response
    (GO:0001964)
  • Synapse
    (GO:0045202)
  • Synaptic transmission, glutamatergic
    (GO:0035249)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)
  • Voltage-gated monoatomic cation channel activity
    (GO:0022843)

Other Information

Genular Protein ID: 3528034200

Symbol: NMDE4_RAT

Name: Glutamate receptor ionotropic, NMDA 2D

UniProtKB Accession Codes:

Q62645 Q63381 Q63382 Q63729 Q63730

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BindingDB 1 BioGRID 1 CDD 2 CTD 1 ChEBI 5 ChEMBL 1 ComplexPortal 1 DrugCentral 1 EMBL 5 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PaxDb 1 Pfam 4 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 4 RefSeq 2 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 UCSC 1 UniProtKB 3 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8428958

Title: Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits.

PubMed ID: 8428958

DOI: 10.1016/s0021-9258(18)53849-7

PubMed ID: 7512349

Title: Developmental and regional expression in the rat brain and functional properties of four NMDA receptors.

PubMed ID: 7512349

DOI: 10.1016/0896-6273(94)90210-0

PubMed ID: 7569905

Title: Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.

PubMed ID: 7569905

DOI: 10.1126/science.7569905

PubMed ID: 9647694

Title: CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.

PubMed ID: 9647694

DOI: 10.1006/mcne.1998.0679

PubMed ID: 21522138

Title: Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.

PubMed ID: 21522138

DOI: 10.1038/ncomms1295

PubMed ID: 23625947

Title: Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors.

PubMed ID: 23625947

DOI: 10.1124/mol.113.085803

Sequence Information:

  • Length: 1323
  • Mass: 143101
  • Checksum: 40F7D60192579564
  • Sequence:
    • MRGAGGPRGP RGPAKMLLLL ALACASPFPE EVPGPGAVGG GTGGARPLNV ALVFSGPAYA 
AEAARLGPAV AAAVRSPGLD VRPVALVLNG SDPRSLVLQL CDLLSGLRVH GVVFEDDSRA 
PAVAPILDFL SAQTSLPIVA VHGGAALVLT PKEKGSTFLQ LGSSTEQQLQ VIFEVLEEYD 
WTSFVAVTTR APGHRAFLSY IEVLTDGSLV GWEHRGALTL DPGAGEAVLG AQLRSVSAQI 
RLLFCAREEA EPVFRAAEEA GLTGPGYVWF MVGPQLAGGG GSGVPGEPLL LPGGSPLPAG 
LFAVRSAGWR DDLARRVAAG VAVVARGAQA LLRDYGFLPE LGHDCRTQNR THRGESLHRY 
FMNITWDNRD YSFNEDGFLV NPSLVVISLT RDRTWEVVGS WEQQTLRLKY PLWSRYGRFL 
QPVDDTQHLT VATLEERPFV IVEPADPISG TCIRDSVPCR SQLNRTHSPP PDAPRPEKRC 
CKGFCIDILK RLAHTIGFSY DLYLVTNGKH GKKIDGVWNG MIGEVFYQRA DMAIGSLTIN 
EERSEIVDFS VPFVETGISV MVARSNGTVS PSAFLEPYSP AVWVMMFVMC LTVVAVTVFI 
FEYLSPVGYN RSLATGKRPG GSTFTIGKSI WLLWALVFNN SVPVENPRGT TSKIMVLVWA 
FFAVIFLASY TANLAAFMIQ EEYVDTVSGL SDRKFQRPQE QYPPLKFGTV PNGSTEKNIR 
SNYPDMHSYM VRYNQPRVEE ALTQLKAGKL DAFIYDAAVL NYMARKDEGC KLVTIGSGKV 
FATTGYGIAL HKGSRWKRPI DLALLQFLGD DEIEMLERLW LSGICHNDKI EVMSSKLDID 
NMAGVFYMLL VAMGLSLLVF AWEHLVYWRL RHCLGPTHRM DFLLAFSRGM YSCCSAEAAP 
PPAKPPPPPQ PLPSPAYPAA RPPPGPAPFV PRERAAADRW RRAKGTGPPG GAAIADGFHR 
YYGPIEPQGL GLGEARAAPR GAAGRPLSPP TTQPPQKPPP SYFAIVREQE PTEPPAGAFP 
GFPSPPAPPA AAAAAVGPPL CRLAFEDESP PAPSRWPRSD PESQPLLGGG AGGPSAGAPT 
APPPRRAAPP PCAYLDLEPS PSDSEDSESL GGASLGGLEP WWFADFPYPY AERLGPPPGR 
YWSVDKLGGW RAGSWDYLPP RGGPAWHCRH CASLELLPPP RHLSCSHDGL DGGWWAPPPP 
PWAAGPPPRR RARCGCPRPH PHRPRASHRA PAAAPHHHRH RRAAGGWDFP PPAPTSRSLE 
DLSSCPRAAP TRRLTGPSRH ARRCPHAAHW GPPLPTASHR RHRGGDLGTR RGSAHFSSLE 
SEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.