Genular: Defining Cellular Identity and Function

Details for: Hgf

Gene ID: 24446

Symbol: Hgf

Ensembl ID: ENSRNOG00000007027

Description: hepatocyte growth factor

Associated with

Drug-mediated inhibition of met activation
(R-RNO-9734091)
Hemostasis
(R-RNO-109582)
Intracellular signaling by second messengers
(R-RNO-9006925)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Met activates pi3k/akt signaling
(R-RNO-8851907)
Met activates ptk2 signaling
(R-RNO-8874081)
Met activates ptpn11
(R-RNO-8865999)
Met activates rap1 and rac1
(R-RNO-8875555)
Met activates ras signaling
(R-RNO-8851805)
Met activates stat3
(R-RNO-8875791)
Met interacts with tns proteins
(R-RNO-8875513)
Met promotes cell motility
(R-RNO-8875878)
Met receptor activation
(R-RNO-6806942)
Met receptor recycling
(R-RNO-8875656)
Negative regulation of met activity
(R-RNO-6807004)
Negative regulation of the pi3k/akt network
(R-RNO-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-RNO-6811558)
Pip3 activates akt signaling
(R-RNO-1257604)
Platelet activation, signaling and aggregation
(R-RNO-76002)
Platelet degranulation
(R-RNO-114608)
Raf/map kinase cascade
(R-RNO-5673001)
Response to elevated platelet cytosolic ca2+
(R-RNO-76005)
Signaling by met
(R-RNO-6806834)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signal transduction
(R-RNO-162582)
Animal organ regeneration
(GO:0031100)
Cell chemotaxis
(GO:0060326)
Cell morphogenesis
(GO:0000902)
Cellular response to hepatocyte growth factor stimulus
(GO:0035729)
Chemoattractant activity
(GO:0042056)
Endopeptidase activity
(GO:0004175)
Epithelial cell proliferation
(GO:0050673)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Hepatocyte growth factor receptor signaling pathway
(GO:0048012)
Identical protein binding
(GO:0042802)
Liver development
(GO:0001889)
Myoblast proliferation
(GO:0051450)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902042)
Negative regulation of hydrogen peroxide-mediated programmed cell death
(GO:1901299)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of release of cytochrome c from mitochondria
(GO:0090201)
Positive chemotaxis
(GO:0050918)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna biosynthetic process
(GO:2000573)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of myelination
(GO:0031643)
Positive regulation of neuron projection regeneration
(GO:0070572)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein-containing complex binding
(GO:0044877)
Proteolysis
(GO:0006508)
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
(GO:0060665)
Regulation of p38mapk cascade
(GO:1900744)
Serine-type endopeptidase activity
(GO:0004252)
Signaling receptor binding
(GO:0005102)
Skeletal muscle cell proliferation
(GO:0014856)

Other Information

Proteins

Hepatocyte growth factor

Genular Protein ID: 4252802213

Symbol: HGF_RAT

Name: Hepatocyte growth factor

UniProtKB Accession Codes:

P17945

Database IDs:

Citations:

PubMed ID: 2139229

Title: Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in rat tissues.

PubMed ID: 2139229

DOI: 10.1073/pnas.87.8.3200

PubMed ID: 2146117

Title: Primary structure of rat hepatocyte growth factor and induction of its mRNA during liver regeneration following hepatic injury.

PubMed ID: 2146117

DOI: 10.1111/j.1432-1033.1990.tb19349.x

Sequence Information:

Length: 728
Mass: 82906
Checksum: 3E0BF1F96ADCEDFF
Sequence:

MMWGTKLLPV LLLQHVLLHL LLLPVTIPYA EGQKKRRNTL HEFKKSAKTT LTKEDPLVKI 
KTKKVNSADE CANRCIRNKG FPFTCKAFVF DKSRKRCYWY PFNSMSSGVK KGFGHEFDLY 
ENKDYIRNCI IGKGGSYKGT VSITKSGIKC QPWNSMIPHE HSFLPSSYRG KDLQENYCRN 
PRGEEGGPWC FTSNPEVRYE VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT 
PHRHKFLPER YPDKGFDDNY CRNPDGKPRP WCYTLDPDTP WEYCAIKMCA HSAVNETDVP 
METTECIKGQ GEGYRGTTNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL RENYCRNPDG 
AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY MGNLSKTRSG LTCSMWDKNM 
EDLHRHIFWE PDASKLTKNY CRNPDDDAHG PWCYTGNPLV PWDYCPISRC EGDTTPTIVN 
LDHPVISCAK TKQLRVVNGI PTQTTVGWMV SLKYRNKHIC GGSLIKESWV LTARQCFPAR 
NKDLKDYEAW LGIHDVHERG EEKRKQILNI SQLVYGPEGS DLVLLKLARP AILDNFVSTI 
DLPSYGCTIP EKTTCSIYGW GYTGLINADG LLRVAHLYIM GNEKCSQHHQ GKVTLNESEL 
CAGAEKIGSG PCEGDYGGPL ICEQHKMRMV LGVIVPGRGC AIPNRPGIFV RVAYYAKWIH 
KVILTYKL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.