Genular: Defining Cellular Identity and Function

Details for: Hmgcs2

Gene ID: 24450

Symbol: Hmgcs2

Ensembl ID: ENSRNOG00000019120

Description: 3-hydroxy-3-methylglutaryl-CoA synthase 2

Associated with

Ketone body metabolism
(R-RNO-74182)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Metabolism of proteins
(R-RNO-392499)
Mitochondrial protein degradation
(R-RNO-9837999)
Synthesis of ketone bodies
(R-RNO-77111)
Acetyl-coa metabolic process
(GO:0006084)
Adipose tissue development
(GO:0060612)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to fatty acid
(GO:0071398)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Cellular response to hormone stimulus
(GO:0032870)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to organic cyclic compound
(GO:0071407)
Cholesterol biosynthetic process
(GO:0006695)
Farnesyl diphosphate biosynthetic process, mevalonate pathway
(GO:0010142)
Hydroxymethylglutaryl-coa synthase activity
(GO:0004421)
Identical protein binding
(GO:0042802)
Ketone body biosynthetic process
(GO:0046951)
Kidney development
(GO:0001822)
Liver development
(GO:0001889)
Lung development
(GO:0030324)
Midgut development
(GO:0007494)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Multicellular organismal response to stress
(GO:0033555)
Response to bacterium
(GO:0009617)
Response to camp
(GO:0051591)
Response to ethanol
(GO:0045471)
Response to fatty acid
(GO:0070542)
Response to glucagon
(GO:0033762)
Response to glucocorticoid
(GO:0051384)
Response to growth hormone
(GO:0060416)
Response to insulin
(GO:0032868)
Response to linoleic acid
(GO:0070543)
Response to metal ion
(GO:0010038)
Response to monosaccharide
(GO:0034284)
Response to nutrient
(GO:0007584)
Response to organic cyclic compound
(GO:0014070)
Response to peptide hormone
(GO:0043434)
Response to prostaglandin f
(GO:0034696)
Response to starvation
(GO:0042594)
Response to temperature stimulus
(GO:0009266)
Response to testosterone
(GO:0033574)
Response to triglyceride
(GO:0034014)
Response to xenobiotic stimulus
(GO:0009410)

Other Information

Proteins

Hydroxymethylglutaryl-CoA synthase, mitochondrial

Genular Protein ID: 2645698030

Symbol: HMCS2_RAT

Name: Hydroxymethylglutaryl-CoA synthase, mitochondrial

UniProtKB Accession Codes:

P22791 F1M9Q5 Q68G44

Database IDs:

Citations:

PubMed ID: 1971108

Title: Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA synthases are encoded by two different genes.

PubMed ID: 1971108

DOI: 10.1073/pnas.87.10.3874

PubMed ID: 8097464

Title: The rat mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme-A-synthase gene contains elements that mediate its multihormonal regulation and tissue specificity.

PubMed ID: 8097464

DOI: 10.1111/j.1432-1033.1993.tb17819.x

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 508
Mass: 56886
Checksum: 9DEAD8EC5F2C6E1A
Sequence:

MQRLLAPARR VLQVKRVMQE SSLSPAHLLP AAQQRFSTIP PAPLAKTDTW PKDVGILALE 
VYFPAQYVDQ TDLEKFNNVE AGKYTVGLGQ TRMGFCSVQE DINSLCLTVV QRLMERTKLP 
WDAVGRLEVG TETIIDKSKA VKTVLMELFQ DSGNTDIEGI DTTNACYGGT ASLFNAANWM 
ESSYWDGRYA LVVCGDIAVY PSGNARPTGG AGAVAMLIGP KAPLVLEQGL RGTHMENAYD 
FYKPNLASEY PLVDGKLSIQ CYLRALDRCY AAYRRKIQNQ WKQAGNNQPF TLDDVQYMIF 
HTPFCKMVQK SLARLMFNDF LSSSSDKQNN LYKGLEAFKG LKLEETYTNK DVDKALLKAS 
LDMFNKKTKA SLYLSTNNGN MYTSSLYGCL ASLLSHHSAQ ELAGSRIGAF SYGSGLAASF 
FSFRVSKDAS PGSPLEKLVS SVSDLPKRLD SRRRMSPEEF TEIMNQREQF YHKVNFSPPG 
DTSNLFPGTW YLERVDEMHR RKYARRPV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hmgcs2

Associated with

Other Information

Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA synthases are encoded by two different genes. PubMed ID: 1971108

The rat mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme-A-synthase gene contains elements that mediate its multihormonal regulation and tissue specificity. PubMed ID: 8097464

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903