Genular: Defining Cellular Identity and Function

Details for: Hmox1

Gene ID: 24451

Symbol: Hmox1

Ensembl ID: ENSRNOG00000014117

Description: heme oxygenase 1

Associated with

Cellular responses to stimuli
(R-RNO-8953897)
Cellular responses to stress
(R-RNO-2262752)
Cellular response to chemical stress
(R-RNO-9711123)
Cytoprotection by hmox1
(R-RNO-9707564)
Heme degradation
(R-RNO-189483)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
(R-RNO-9609523)
Iron uptake and transport
(R-RNO-917937)
Metabolism
(R-RNO-1430728)
Metabolism of porphyrins
(R-RNO-189445)
Protein localization
(R-RNO-9609507)
Regulation of hmox1 expression and activity
(R-RNO-9707587)
Transport of small molecules
(R-RNO-382551)
Angiogenesis
(GO:0001525)
Arachidonic acid omega-hydroxylase activity
(GO:0052869)
Caveola
(GO:0005901)
Cellular response to arsenic-containing substance
(GO:0071243)
Cellular response to cadmium ion
(GO:0071276)
Cellular response to cisplatin
(GO:0072719)
Cellular response to heat
(GO:0034605)
Cellular response to hypoxia
(GO:0071456)
Cellular response to nutrient
(GO:0031670)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Epithelial cell apoptotic process
(GO:1904019)
Erythrocyte homeostasis
(GO:0034101)
Heme binding
(GO:0020037)
Heme catabolic process
(GO:0042167)
Heme metabolic process
(GO:0042168)
Heme oxidation
(GO:0006788)
Heme oxygenase (decyclizing) activity
(GO:0004392)
Identical protein binding
(GO:0042802)
Intracellular iron ion homeostasis
(GO:0006879)
Intracellular signal transduction
(GO:0035556)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Liver regeneration
(GO:0097421)
Macroautophagy
(GO:0016236)
Metal ion binding
(GO:0046872)
Multicellular organismal-level iron ion homeostasis
(GO:0060586)
Negative regulation by host of viral transcription
(GO:0043922)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epithelial cell apoptotic process
(GO:1904036)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902042)
Negative regulation of macroautophagy
(GO:0016242)
Negative regulation of mast cell cytokine production
(GO:0032764)
Negative regulation of mast cell degranulation
(GO:0043305)
Negative regulation of muscle cell apoptotic process
(GO:0010656)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of smooth muscle cell proliferation
(GO:0048662)
Negative regulation of vascular associated smooth muscle cell proliferation
(GO:1904706)
Negative regulation of viral life cycle
(GO:1903901)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Phospholipase d activity
(GO:0004630)
Phospholipid metabolic process
(GO:0006644)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:1903589)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell migration involved in sprouting angiogenesis
(GO:0090050)
Positive regulation of epithelial cell apoptotic process
(GO:1904037)
Positive regulation of macroautophagy
(GO:0016239)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of blood pressure
(GO:0008217)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to 3-methylcholanthrene
(GO:1904681)
Response to arachidonic acid
(GO:1904550)
Response to estrogen
(GO:0043627)
Response to hydrogen peroxide
(GO:0042542)
Response to hypoxia
(GO:0001666)
Response to nicotine
(GO:0035094)
Response to oxidative stress
(GO:0006979)
Response to xenobiotic stimulus
(GO:0009410)
Small gtpase-mediated signal transduction
(GO:0007264)
Structural molecule activity
(GO:0005198)
Wound healing involved in inflammatory response
(GO:0002246)

Other Information

Proteins

Heme oxygenase 1

Genular Protein ID: 3305846029

Symbol: HMOX1_RAT

Name: Heme oxygenase 1

UniProtKB Accession Codes:

P06762 Q5BK87

Database IDs:

Citations:

PubMed ID: 3032976

Title: Nucleotide sequence and organization of the rat heme oxygenase gene.

PubMed ID: 3032976

DOI: 10.1016/s0021-9258(18)48315-9

PubMed ID: 3865203

Title: Cloning and expression of cDNA for rat heme oxygenase.

PubMed ID: 3865203

DOI: 10.1073/pnas.82.23.7865

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1935972

Title: Expression of rat heme oxygenase in Escherichia coli as a catalytically active, full-length form that binds to bacterial membranes.

PubMed ID: 1935972

DOI: 10.1111/j.1432-1033.1991.tb16357.x

PubMed ID: 1575508

Title: Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal.

PubMed ID: 1575508

DOI: 10.1016/0003-9861(92)90481-b

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 10760513

Title: Crystal structure of rat heme oxygenase-1 in complex with heme.

PubMed ID: 10760513

DOI: 10.1016/s0014-5793(00)01353-3

Sequence Information:

Length: 289
Mass: 33006
Checksum: EF7D2B98048AF44D
Sequence:

MERPQLDSMS QDLSEALKEA TKEVHIRAEN SEFMRNFQKG QVSREGFKLV MASLYHIYTA 
LEEEIERNKQ NPVYAPLYFP EELHRRAALE QDMAFWYGPH WQEAIPYTPA TQHYVKRLHE 
VGGTHPELLV AHAYTRYLGD LSGGQVLKKI AQKAMALPSS GEGLAFFTFP SIDNPTKFKQ 
LYRARMNTLE MTPEVKHRVT EEAKTAFLLN IELFEELQAL LTEEHKDQSP SQTEFLRQRP 
ASLVQDTTSA ETPRGKSQIS TSSSQTPLLR WVLTLSFLLA TVAVGIYAM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hmox1

Associated with

Other Information

Nucleotide sequence and organization of the rat heme oxygenase gene. PubMed ID: 3032976

Cloning and expression of cDNA for rat heme oxygenase. PubMed ID: 3865203

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression of rat heme oxygenase in Escherichia coli as a catalytically active, full-length form that binds to bacterial membranes. PubMed ID: 1935972

Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal. PubMed ID: 1575508

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Crystal structure of rat heme oxygenase-1 in complex with heme. PubMed ID: 10760513