Genular: Defining Cellular Identity and Function

Details for: Hspa8

Gene ID: 24468

Symbol: Hspa8

Ensembl ID: ENSRNOG00000034066

Description: heat shock protein family A (Hsp70) member 8

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-RNO-1169410)
Attenuation phase
(R-RNO-3371568)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-RNO-450408)
Cellular responses to stimuli
(R-RNO-8953897)
Cellular responses to stress
(R-RNO-2262752)
Cellular response to heat stress
(R-RNO-3371556)
Clathrin-mediated endocytosis
(R-RNO-8856828)
Cytokine signaling in immune system
(R-RNO-1280215)
Gaba synthesis, release, reuptake and degradation
(R-RNO-888590)
Golgi associated vesicle biogenesis
(R-RNO-432722)
Hsf1-dependent transactivation
(R-RNO-3371571)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-RNO-3371497)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Interferon signaling
(R-RNO-913531)
Lysosome vesicle biogenesis
(R-RNO-432720)
Membrane trafficking
(R-RNO-199991)
Metabolism of proteins
(R-RNO-392499)
Metabolism of rna
(R-RNO-8953854)
Mrna splicing
(R-RNO-72172)
Mrna splicing - major pathway
(R-RNO-72163)
Neuronal system
(R-RNO-112316)
Neurotransmitter release cycle
(R-RNO-112310)
Neutrophil degranulation
(R-RNO-6798695)
Pkr-mediated signaling
(R-RNO-9833482)
Post-translational protein modification
(R-RNO-597592)
Processing of capped intron-containing pre-mrna
(R-RNO-72203)
Protein methylation
(R-RNO-8876725)
Regulation of hsf1-mediated heat shock response
(R-RNO-3371453)
Regulation of mrna stability by proteins that bind au-rich elements
(R-RNO-450531)
Trans-golgi network vesicle budding
(R-RNO-199992)
Transmission across chemical synapses
(R-RNO-112315)
Vesicle-mediated transport
(R-RNO-5653656)
A1 adenosine receptor binding
(GO:0031686)
Adp binding
(GO:0043531)
Atp-dependent protein disaggregase activity
(GO:0140545)
Atp-dependent protein folding chaperone
(GO:0140662)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Atp metabolic process
(GO:0046034)
Axo-dendritic transport
(GO:0008088)
C3hc4-type ring finger domain binding
(GO:0055131)
Cellular response to heat
(GO:0034605)
Cerebellum development
(GO:0021549)
Chaperone-mediated autophagy
(GO:0061684)
Chaperone-mediated protein folding
(GO:0061077)
Chaperone cofactor-dependent protein refolding
(GO:0051085)
Clathrin-uncoating atpase activity
(GO:1990833)
Enzyme binding
(GO:0019899)
Estrous cycle
(GO:0044849)
Forebrain development
(GO:0030900)
G1/s transition of mitotic cell cycle
(GO:0000082)
G protein-coupled receptor binding
(GO:0001664)
Heat shock protein binding
(GO:0031072)
Kidney development
(GO:0001822)
Late endosomal microautophagy
(GO:0061738)
Modulation by host of viral process
(GO:0044788)
Mrna processing
(GO:0006397)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of dna-templated transcription
(GO:0045892)
Peptide binding
(GO:0042277)
Phosphatidylserine binding
(GO:0001786)
Positive regulation by host of viral genome replication
(GO:0044829)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mrna splicing, via spliceosome
(GO:0048026)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of proteolysis
(GO:0045862)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Prostaglandin binding
(GO:1904593)
Protein-containing complex disassembly
(GO:0032984)
Protein-folding chaperone binding
(GO:0051087)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein folding
(GO:0006457)
Protein folding chaperone
(GO:0044183)
Protein import into nucleus
(GO:0006606)
Protein refolding
(GO:0042026)
Protein transmembrane import into intracellular organelle
(GO:0044743)
Regulation of cell cycle
(GO:0051726)
Regulation of protein complex stability
(GO:0061635)
Regulation of protein stability
(GO:0031647)
Response to activity
(GO:0014823)
Response to estradiol
(GO:0032355)
Response to ethanol
(GO:0045471)
Response to nickel cation
(GO:0010045)
Response to progesterone
(GO:0032570)
Response to starvation
(GO:0042594)
Response to xenobiotic stimulus
(GO:0009410)
Rna binding
(GO:0003723)
Rna splicing
(GO:0008380)
Signaling receptor binding
(GO:0005102)
Skeletal muscle tissue development
(GO:0007519)
Synaptic vesicle uncoating
(GO:0016191)
Ubiquitin protein ligase binding
(GO:0031625)
Unfolded protein binding
(GO:0051082)

Other Information

Proteins

Heat shock cognate 71 kDa protein

Genular Protein ID: 1655297788

Symbol: HSP7C_RAT

Name: Heat shock cognate 71 kDa protein

UniProtKB Accession Codes:

P63018 P08109 P12225 Q4FZY7 Q62373 Q62374 Q62375

Database IDs:

Citations:

PubMed ID: 3595567

Title: Cloning and expression of a gene encoding hsc73, the major hsp70-like protein in unstressed rat cells.

PubMed ID: 3595567

DOI: 10.1002/j.1460-2075.1987.tb04850.x

PubMed ID: 3939319

Title: Constitutively expressed rat mRNA encoding a 70-kilodalton heat-shock-like protein.

PubMed ID: 3939319

DOI: 10.1128/mcb.5.12.3476-3483.1985

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10567422

Title: Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats.

PubMed ID: 10567422

DOI: 10.1074/jbc.274.48.34425

PubMed ID: 15708368

Title: Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions.

PubMed ID: 15708368

DOI: 10.1016/j.abb.2004.12.020

PubMed ID: 10373374

Title: High-resolution solution structure of the 18 kDa substrate-binding domain of the mammalian chaperone protein Hsc70.

PubMed ID: 10373374

DOI: 10.1006/jmbi.1999.2776

Sequence Information:

Length: 646
Mass: 70871
Checksum: 03A27B30E6C076ED
Sequence:

MSKGPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA 
MNPTNTVFDA KRLIGRRFDD AVVQSDMKHW PFMVVNDAGR PKVQVEYKGE TKSFYPEEVS 
SMVLTKMKEI AEAYLGKTVT NAVVTVPAYF NDSQRQATKD AGTIAGLNVL RIINEPTAAA 
IAYGLDKKVG AERNVLIFDL GGGTFDVSIL TIEDGIFEVK STAGDTHLGG EDFDNRMVNH 
FIAEFKRKHK KDISENKRAV RRLRTACERA KRTLSSSTQA SIEIDSLYEG IDFYTSITRA 
RFEELNADLF RGTLDPVEKA LRDAKLDKSQ IHDIVLVGGS TRIPKIQKLL QDFFNGKELN 
KSINPDEAVA YGAAVQAAIL SGDKSENVQD LLLLDVTPLS LGIETAGGVM TVLIKRNTTI 
PTKQTQTFTT YSDNQPGVLI QVYEGERAMT KDNNLLGKFE LTGIPPAPRG VPQIEVTFDI 
DANGILNVSA VDKSTGKENK ITITNDKGRL SKEDIERMVQ EAEKYKAEDE KQRDKVSSKN 
SLESYAFNMK ATVEDEKLQG KINDEDKQKI LDKCNEIISW LDKNQTAEKE EFEHQQKELE 
KVCNPIITKL YQSAGGMPGG MPGGFPGGGA PPSGGASSGP TIEEVD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hspa8

Associated with

Other Information

Cloning and expression of a gene encoding hsc73, the major hsp70-like protein in unstressed rat cells. PubMed ID: 3595567

Constitutively expressed rat mRNA encoding a 70-kilodalton heat-shock-like protein. PubMed ID: 3939319

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats. PubMed ID: 10567422

Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions. PubMed ID: 15708368