Genular: Defining Cellular Identity and Function

Details for: Hspa1a

Gene ID: 24472

Symbol: Hspa1a

Description: heat shock protein family A (Hsp70) member 1A

Associated with

Aggresome
(GO:0016235)
Apical plasma membrane
(GO:0016324)
Atp-dependent protein disaggregase activity
(GO:0140545)
Atp-dependent protein folding chaperone
(GO:0140662)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Atp metabolic process
(GO:0046034)
Basolateral plasma membrane
(GO:0016323)
Binding of sperm to zona pellucida
(GO:0007339)
C3hc4-type ring finger domain binding
(GO:0055131)
Cell body
(GO:0044297)
Cellular heat acclimation
(GO:0070370)
Cellular response to heat
(GO:0034605)
Cellular response to unfolded protein
(GO:0034620)
Centriole
(GO:0005814)
Centrosome
(GO:0005813)
Chaperone-mediated protein complex assembly
(GO:0051131)
Chaperone cofactor-dependent protein refolding
(GO:0051085)
Cop9 signalosome
(GO:0008180)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Death receptor agonist activity
(GO:0038177)
Defense response
(GO:0006952)
Denatured protein binding
(GO:0031249)
Disordered domain specific binding
(GO:0097718)
Enzyme binding
(GO:0019899)
Extracellular space
(GO:0005615)
G protein-coupled receptor binding
(GO:0001664)
Heat shock protein binding
(GO:0031072)
Histone deacetylase binding
(GO:0042826)
Inclusion body
(GO:0016234)
Lysosomal transport
(GO:0007041)
Membrane raft
(GO:0045121)
Misfolded protein binding
(GO:0051787)
Mitochondrion
(GO:0005739)
Mrna catabolic process
(GO:0006402)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
(GO:1902236)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Negative regulation of inclusion body assembly
(GO:0090084)
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
(GO:1901029)
Negative regulation of myeloid cell apoptotic process
(GO:0033033)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Negative regulation of vasoconstriction
(GO:0045906)
Nf-kappab binding
(GO:0051059)
Nuclear speck
(GO:0016607)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of microtubule nucleation
(GO:0090063)
Positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
(GO:0070434)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of rna splicing
(GO:0033120)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Positive regulation of tumor necrosis factor-mediated signaling pathway
(GO:1903265)
Protease binding
(GO:0002020)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein folding
(GO:0006457)
Protein folding chaperone
(GO:0044183)
Protein refolding
(GO:0042026)
Protein stabilization
(GO:0050821)
Receptor ligand activity
(GO:0048018)
Regulation of mitotic spindle assembly
(GO:1901673)
Regulation of protein ubiquitination
(GO:0031396)
Response to heat
(GO:0009408)
Response to unfolded protein
(GO:0006986)
Ribonucleoprotein complex
(GO:1990904)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Transcription corepressor activity
(GO:0003714)
Transcription regulator inhibitor activity
(GO:0140416)
Ubiquitin protein ligase binding
(GO:0031625)
Unfolded protein binding
(GO:0051082)
Zona pellucida receptor complex
(GO:0002199)

Other Information

Proteins

Heat shock 70 kDa protein 1A

Genular Protein ID: 2231383649

Symbol: HS71A_RAT

Name: Heat shock 70 kDa protein 1A

UniProtKB Accession Codes:

P0DMW0 P42853 Q07439 Q63256

Database IDs:

Citations:

PubMed ID: 7927536

Title: Comparative analysis of the three major histocompatibility complex-linked heat shock protein 70 (Hsp70) genes of the rat.

PubMed ID: 7927536

DOI: 10.1007/bf01246673

PubMed ID: 15060004

Title: The genomic sequence and comparative analysis of the rat major histocompatibility complex.

PubMed ID: 15060004

DOI: 10.1101/gr.1987704

Sequence Information:

Length: 641
Mass: 70185
Checksum: 2D745B1013F64E7B
Sequence:

MAKKTAIGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA 
LNPQNTVFDA KRLIGRKFGD PVVQSDMKHW PFQVVNDGDK PKVQVNYKGE NRSFYPEEIS 
SMVLTKMKEI AEAYLGHPVT NAVITVPAYF NDSQRQATKD AGVIAGLNVL RIINEPTAAA 
IAYGLDRTGK GERNVLIFDL GGGTFDVSIL TIDDGIFEVK ATAGDTHLGG EDFDNRLVSH 
FVEEFKRKHK KDISQNKRAV RRLRTACERA KRTLSSSTQA SLEIDSLFEG IDFYTSITRA 
RFEELCSDLF RGTLEPVEKA LRDAKLDKAQ IHDLVLVGGS TRIPKVQKLL QDFFNGRDLN 
KSINPDEAVA YGAAVQAAIL MGDKSENVQD LLLLDVAPLS LGLETAGGVM TALIKRNSTI 
PTKQTQTFTT YSDNQPGVLI QVYEGERAMT RDNNLLGRFE LSGIPPAPRG VPQIEVTFDI 
DANGILNVTA TDKSTGKANK ITITNDKGRL SKEEIERMVQ EAERYKAEDE VQRERVAAKN 
ALESYAFNMK SAVEDEGLKG KISEADKKKV LDKCQEVISW LDSNTLAEKE EFVHKREELE 
RVCNPIISGL YQGAGAPGAG GFGAQAPKGG SGSGPTIEEV D

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.