Details for: Ifnb1

Gene ID: 24481

Symbol: Ifnb1

Ensembl ID: ENSRNOG00000006268

Description: interferon beta 1

Associated with

  • Cytokine signaling in immune system
    (R-RNO-1280215)
  • Immune system
    (R-RNO-168256)
  • Interferon alpha/beta signaling
    (R-RNO-909733)
  • Interferon signaling
    (R-RNO-913531)
  • Regulation of ifna/ifnb signaling
    (R-RNO-912694)
  • Adaptive immune response
    (GO:0002250)
  • B cell activation involved in immune response
    (GO:0002312)
  • B cell differentiation
    (GO:0030183)
  • B cell proliferation
    (GO:0042100)
  • Cellular response to dexamethasone stimulus
    (GO:0071549)
  • Cellular response to dsdna
    (GO:1990786)
  • Cellular response to dsrna
    (GO:0071359)
  • Cellular response to exogenous dsrna
    (GO:0071360)
  • Cellular response to interferon-beta
    (GO:0035458)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to virus
    (GO:0098586)
  • Chloramphenicol o-acetyltransferase activity
    (GO:0008811)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytokine activity
    (GO:0005125)
  • Cytokine receptor binding
    (GO:0005126)
  • Defense response to bacterium
    (GO:0042742)
  • Defense response to virus
    (GO:0051607)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Extracellular space
    (GO:0005615)
  • Humoral immune response
    (GO:0006959)
  • Innate immune response
    (GO:0045087)
  • Macrophage activation involved in immune response
    (GO:0002281)
  • Natural killer cell activation involved in immune response
    (GO:0002323)
  • Negative regulation of blood-brain barrier permeability
    (GO:1905604)
  • Negative regulation of cell adhesion molecule production
    (GO:0060354)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of immunoglobulin production
    (GO:0002638)
  • Negative regulation of lewy body formation
    (GO:0140123)
  • Negative regulation of matrix metallopeptidase secretion
    (GO:1904465)
  • Negative regulation of mononuclear cell migration
    (GO:0071676)
  • Negative regulation of neuroinflammatory response
    (GO:0150079)
  • Negative regulation of osteoclast differentiation
    (GO:0045671)
  • Negative regulation of t-helper 2 cell cytokine production
    (GO:2000552)
  • Negative regulation of t cell differentiation
    (GO:0045581)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Negative regulation of viral genome replication
    (GO:0045071)
  • Neuron cellular homeostasis
    (GO:0070050)
  • Positive regulation of apoptotic signaling pathway
    (GO:2001235)
  • Positive regulation of autophagy
    (GO:0010508)
  • Positive regulation of peptidyl-serine phosphorylation of stat protein
    (GO:0033141)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of transforming growth factor beta production
    (GO:0071636)
  • Receptor signaling pathway via jak-stat
    (GO:0007259)
  • Response to exogenous dsrna
    (GO:0043330)
  • T cell activation involved in immune response
    (GO:0002286)
  • Type i interferon-mediated signaling pathway
    (GO:0060337)
  • Type i interferon receptor binding
    (GO:0005132)

Other Information

Genular Protein ID: 2581038097

Symbol: IFNB_RAT

Name: Interferon beta

UniProtKB Accession Codes:

P70499

Database IDs:

AGR 1 AlphaFoldDB 1 CDD 1 CTD 1 EMBL 1 Ensembl 4 GO 35 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9126338

Title: Isolation and expression of rat interferon beta gene and growth-inhibitory effect of its expression on rat glioma cells.

PubMed ID: 9126338

DOI: 10.1006/bbrc.1997.6359

PubMed ID: 16641100

Title: Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.

PubMed ID: 16641100

DOI: 10.1073/pnas.0600895103

Sequence Information:

  • Length: 184
  • Mass: 22073
  • Checksum: 1D051D29F979ADDE
  • Sequence:
    • MANRWTLHIA FLLCFSTTAL SIDYKQLQFR QSTSIRTCQK LLRQLNGRLN LSYRTDFKIP 
MEVMHPSQME KSYTAFAIQV MLQNVFLVFR SNFSSTGWNE TIVESLLDEL HQQTELLEII 
LKEKQEERLT WVTSTTTLGL KSYYWRVQRY LKDKKYNSYA WMVVRAEVFR NFSIILRLNR 
NFQN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.